A5027647977- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Reproductive Physiology in Livestock
- Ovarian function and disorders
- Computational Drug Discovery Methods
- Reproductive Health and Technologies
- Genetic and phenotypic traits in livestock
- Renal and related cancers
- Mycotoxins in Agriculture and Food
- Complement system in diseases
- Chemical Synthesis and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Assisted Reproductive Technology and Twin Pregnancy
- Veterinary Equine Medical Research
- Plant Toxicity and Pharmacological Properties
- Plant and fungal interactions
- Peptidase Inhibition and Analysis
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Invertebrate Immune Response Mechanisms
- Hungarian Social, Economic and Educational Studies
- Effects of Environmental Stressors on Livestock
- Animal Genetics and Reproduction
- Rabbits: Nutrition, Reproduction, Health
- Protease and Inhibitor Mechanisms
University of Veterinary Medicine
2016-2025
Magyar Agrár- és Élettudományi Egyetem
2006-2018
TOBB University of Economics and Technology
2017
Szent János Kórház
2004-2016
Hungarian Academy of Sciences
1996-2012
Target (United States)
2011
Institut de Biologie Structurale
2000-2004
Université Grenoble Alpes
2000-2004
Université Joseph Fourier
2002-2004
Children's Hospital of New Orleans
2004
Mannan-binding lectin (MBL)-associated serine proteases-1 and 2 (MASP-1 MASP-2) are homologous modular proteases that each interact with MBL, an oligomeric serum involved in innate immunity. To precisely determine their substrate specificity, human MASP-1 MASP-2, fragments from catalytic regions were expressed using a baculovirus/insect cells system. Recombinant MASP-2 displayed rather wide, C1s-like esterolytic activity, specifically cleaved complement proteins C2 C4, relative efficiencies...
Motility is one of the most important characteristics associated with fertilising ability spermatozoa indicating their viability and structural integrity. Therefore, examination motility constitutes an integral part semen analysis. Computer-assisted analysis (CASA) allows accurate objective assessment different sperm motion high repeatability. The aim this study was to evaluate kinematic (velocity) parameters frozen/thawed bull determine if any them could be correlated capability after...
Abstract The mannan-binding lectin (MBL) activation pathway of complement plays an important role in the innate immune defense against pathogenic microorganisms. In human serum, two MBL-associated serine proteases (MASP-1, MASP-2) and protein 19 (MAp19) were found to be associated with MBL. With a view investigate interaction properties these proteins, MASP-1, MASP-2, MAp19, as well N-terminal subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1-epidermal growth factor (CUB-EGF)...
Abstract Mannan-binding lectin (MBL)-associated serine proteases (MASP-1, -2, and -3) are homologous modular that each associate with MBL L- H-ficolins, which oligomeric serum lectins involved in innate immunity. To investigate its physicochemical, interaction, enzymatic properties, human MASP-3 was expressed insect cells. Ultracentrifugation analysis indicated rMASP-3 sedimented as a homodimer (s20,w = 6.2 ± 0.1 S) the presence of Ca2+, monomer 4.6 EDTA. As shown by surface plasmon...
A szerzők vizsgálták a különböző vitrifikációs technikák (kriocső és open pulled straw) hatását preantralis tüszők túlélésére felolvasztás után. túlélési arányt felolvasztott in vitro tenyésztésével tesztelték, amelynek során nyomon követték növekedését ösztradioltermelését. tenyésztése rendkívül jelentős mennyiségű petesejthez biztosíthat hozzáférést, amelyek maturálhatók termékenyíthetők, kifejlődött embriók beültethetők vagy fagyasztva tárolhatók. tanulmány célja tüszőprezerváló...
Abstract The anti-Müllerian hormone (AMH) is a granulosa cell-derived that has been associated with female fertility and reflects the population of growing follicles. This study aimed to evaluate average concentration AMH in Lipizzaner mares, as well determine relationship between follicle number size. We also investigated age mares their levels. possible effect seasonality levels was assessed. Twenty-three 6 24 years were included experiment. Mares divided into two groups: Group 1 aged – 15...
Abstract Ficolins are oligomeric lectins comprising a collagen-like and fibrinogen-like domain, with binding specificity for N-acetylglucosamine. It has been reported recently that L-ficolin/P35 associates mannan-binding lectin (MBL)-associated serine proteases (MASP-1 -2) MBL-associated protein 19 (MAp19) in serum forms complexes able to activate complement. Using surface plasmon resonance spectroscopy we have shown recombinant MASP-1 -2, their N-terminal CUB1 (module originally found...
The aim of this study was to evaluate the effects vitrification on morpho-functional parameters (blastomere/chromatin integrity and bioenergy/oxidative potential) mouse preimplantation embryos.In vivo produced (4/16-cell, morulae blastocyst-stage) embryos were randomly divided into control groups. For vitrification, exposed a 2-step loading ethylene glycol propylene glycol, before being placed in small nylon loop submerged liquid nitrogen. After warming, cryoprotectants diluted by 3-step...
The ability to cryopreserve mammalian embryos has become an integral part of assisted reproduction, both in human and veterinary medicine. Despite differences the size physiological characteristics from various species, have been frozen by either two procedures: slow freezing or vitrification. aim our study was compare effect vitrification chromatin structure, energy status reactive oxygen species production mouse morulae blastocysts.Mouse blastocysts were randomly allocated into...
Summary Biochemical modifications of zona pellucida (ZP) result in hardening. Zona hardening (ZH) is induced by several factors such as advancing maternal age, vitro culture conditions and cryopreservation adversely effects implantation. The objective the clinical study was to determine whether or not laser-assisted hatching (LAH) applied on day 3 frozen embryos improves outcome embryo transfer (FET) cycles patients with recurrent implantation failure and/or advanced female age. In total,...
Alzheimer's disease (AD) is a complex and widespread condition, still not fully understood with no cure yet. Amyloid beta (Aβ) peptide suspected to be major cause of AD, therefore, simultaneously blocking its formation aggregation by inhibition the enzymes BACE-1 (β-secretase) AChE (acetylcholinesterase) single inhibitor may an effective therapeutic approach, as compared one these targets or combining two drugs, for each targets. We used our ISE algorithm model peripheral site inhibitors...
The hepatocyte growth factor/scatter factor (HGF/SF) tyrosine kinase (TK) receptor c-Met plays a crucial role in the development of invasive phenotype tumors and thus represents an attractive candidate for targeted therapies variety malignancies, including human malignant melanoma (MM). In contrast to what has been shown previously, we were not able detect any genetic alterations, either juxtamembrane- or TK-domain c-Met, studied MM cell lines. Nevertheless, was constitutively active these...