A5011752286- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Medical research and treatments
- S100 Proteins and Annexins
- Developmental and Educational Neuropsychology
- Attention Deficit Hyperactivity Disorder
- Business, Education, Mathematics Research
- Mitochondrial Function and Pathology
- Rabies epidemiology and control
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Archaeological and Historical Studies
- EEG and Brain-Computer Interfaces
- Neurogenesis and neuroplasticity mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Archaeological and Geological Studies
- Neural and Behavioral Psychology Studies
- Cell death mechanisms and regulation
- Neurology and Historical Studies
- Latin American history and culture
- Diverse Applied Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Temporomandibular Joint Disorders
- Neuroscience of respiration and sleep
Universidad del Valle
1991-2018
Instituto Cajal
2004
Universidad de Antioquia
2004
Centro Nacional de Biotecnología
2004
Eunice Kennedy Shriver Center
1986
Traumatic brain injury (TBI) produces several cellular changes, such as gliosis, axonal and dendritic plasticity, inhibition-excitation imbalance, well cell death, which can initiate epileptogenesis. It has been demonstrated that dysfunction of the inhibitory components cerebral cortex after may cause status epilepticus in experimental models; we proposed to analyze response cortical interneurons astrocytes TBI humans. Twelve contusion samples were evaluated, identifying expression glial...
The von Economo neurons (VEN) are characterized by a large soma, spindle-like with little dendritic arborization at both, the basal and apical poles. In humans, VENs have been described in entorhinal cortex, hippocampal formation, anterior cingulate rostral portion of insula, dorsomedial Brodmann´s area 9 (BA9). These cortical regions associated cognitive functions such as social interactions, intuition emotional processing. Previous studies that searched for presence these cells lateral...
Rabies has been an enigmatic disease of the nervous system because microscopic findings in brain tissue are not paralleled by severity clinical illness. The calcium binding protein calbindin (CB) is a neuronal marker great interest neuroanatomy and neuropathology. CB-ir neurons striatum cerebral cortex gabaergic cells. In present work CB-immunoreactivity was evaluated brains normal rabies-infected mice. infection caused loss CB-immunostaining cortical supragranular layers as well striatum....
During cerebral ischemia, part of the damage associated with hyperactivation glutamate receptors results from hyperphosphorylation microtubule-associated protein Tau. Previous studies have shown that estradiol treatment reduces neural after ischemia. Here, we show transient occlusion middle artery in Tau and a significant increase association glycogen synthase kinase-3beta alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid type receptor subunits 2/3 hippocampus. Estradiol decreased...
Some clinical features of rabies and experimental evidence from cell culture laboratory animals suggest impairment gabaergic neurotransmission. Several types neurons occur in the cerebral cortex. They can be identified by three neuronal markers: calcium binding proteins (CaBPs) parvalbumin (PV), calbindin (CB) calretinin (CR). Rabies virus spreads throughout cortex; however, cytopathic effects on are unknown. The expression calcium-binding (CR) was studied frontal cortex mice. effect...
After occlusion of the middle cerebral artery in rats, a robust neuronal loss occurs ipsilateral substantia nigra reticulata. In this study we have assessed whether degeneration is accompanied by changes expression anti-apoptotic protein Bcl-2. Neuronal was nuclei (NeuN) immunoreactivity. A significant decrease Bcl-2 observed 12, 24 and 72 h after occlusion. These results suggest that secondary could be related with modification proteins regulating programmed cell death. Exo-focal death may...
Background: Prefrontal cortex (PFC) represents the highest level of integration and control psychic behavioral states. Several dysfunctions such as autism, hyperactivity disorders, depression, schizophrenia have been related with alterations in prefrontal (PFC). Among cortical layers PFC, layer II shows a particular vertical pattern organization, cell density biggest non-pyramidal/pyramidal neuronal ratio. We currently characterized cytoarchitecture human areas 10, 24, 46. Objective: focused...
Introduction: Traumatic brain injury (TBI) is a heterogeneous phenomenon from molecular, cellular and pathological perspective. Clinical outcome also extremely variable. It considered that such diversity response to TBI related the primary intensity, associated secondary events (hypoxia, ischemia, oedema inflammation), metabolic patient state, genetic background, age, gender, etc. After histopathological variable in time space. In order determine anatomofunctional integrity of nerve cells...
Programmed cell death occurs as a physiological process during development. In the brain and spinal cord this event determines number location of different types. adulthood, programmed or apoptosis is more restricted but it may play major role in acute chronic pathological entities. However, contrast to other tissues where has been widely documented from morphological point view, central nervous system complete anatomical evidence scanty. spite there consensus about activation signal systems...
Introduction: Traumatic brain injury is a global medical problem whose survivors may show disability and neurological or psychiatric sequelae. In the last few years knowledge of physiopathological mechanisms TBI has increase but still it not entirely known. For this reason research turn over in one´s mind new strategies to study pathology looking for neuroprotection. Objective: The aim work develop an organotypic culture cortical human neurons derived from contusion tissue obtain patients...
Introduccion: El trauma craneoencefalico (TCE)es un fenomeno heterogeneo desde el punto de vista molecular, celular y en la respuesta clinica. Se considera que esta diversidad se debe a intensidad injuria primaria, eventos secundarios asociados (hipoxia, isquemia, edema, inflamacion), al estado metabolico del paciente, su base genetica, edad, genero, etc. Para determinar integridad anatomo-funcional las celulas nerviosas es importante verificar cito, dendroarquitectura preservacion laminar...
Introduction: The brain is an extraordinarily dynamic structure specially its physiology in response to pathological events. This include several mechanisms such as changes cell metabolism, genes expression and possible modifications phenotype connectivity that reflect activation of processes like neurogenesis, neuritogenesis synaptogenesis. Several aspects related with neuroplasticity has been proposed part the pathophysiological bases understand ischemia exofocal phenomena. Progress...