A5091141685- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Viral Infections and Immunology Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Disease and Adiposity
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Advanced battery technologies research
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Innovation Policy and R&D
- Intracerebral and Subarachnoid Hemorrhage Research
Universitätsklinikum Würzburg
2021-2024
Comprehensive Cancer Center Mainfranken
2020-2022
Leopoldina Krankenhaus Schweinfurt
2018-2021
Deutsches Herzzentrum der Charité
2020
Deutsche Lepra- und Tuberkulosehilfe
2020
Stiftung Juliusspital
2020
Sorbonne Paris Cité
2019
Université Paris Cité
2019
Délégation Paris 5
2019
Saarland University
2019
Echocardiographic diagnosis of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) often requires extensive provocative manoeuvers. We investigated, whether echocardiography-derived parameters obtained at rest can aid to determine the presence LVOTO persons with HCM.Consecutive patients HCM admitted a referral centre underwent standardized transthoracic echocardiographic examination including Under resting conditions, length mitral leaflets and distances...
Hypertrophic cardiomyopathy is the most common genetic cardiac disease and characterized by left ventricular hypertrophy. Although this hypertrophy often associates with sarcomeric gene mutations, nongenetic factors also contribute to disease, leading diastolic dysfunction. Notably, dysfunction manifests before linked hypercontractility, as well nonuniform contraction relaxation (myofibril asynchrony) of myocardium. distribution in hypertrophic can vary both between within individuals,...
Abstract Aims Since its introduction, alcohol septal ablation (PTSMA) was discussed as treatment option only in elderly symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM). We report on long‐term follow‐up after PTSMA respect to patient's age. Methods and results Between May 2000 June 2017, we treated 952 consecutive HOCM PTSMA; 133 (14.0%) were <40 years of age (Group A; mean 30.3 ± 7.6; 26.3% female), 422 (44.3%) between ≥40 <60 B; 50.6 5.8; 27.0% 397 (41.7%) ≥60...
Myocardial work (MyW) is an echocardiographically derived parameter to estimate myocardial performance. The calculation of MyW utilizes pressure strain loops from global longitudinal and brachial blood (BP) as a surrogate left ventricular systolic (LVSP). Since LVSP cannot be equated with BP in hypertrophic obstructive cardiomyopathy (HOCM), we explored whether can non-invasively by combining Doppler gradients BP.
Journal Article Misplacement in myocardial contrast echo during alcohol septal ablation hypertrophic obstructive cardiomyopathy indicates intraseptal collateralization Get access Hubert Seggewiss, Seggewiss Comprehensive Heart Failure Center, University Hospital Würzburg, Am Schwarzenberg 15, Haus A15, Würzburg 97078, GermanyDepartment of Internal Medicine I, Germany Corresponding author. E-mail: seggewiss.hubert@t-online.de https://orcid.org/0000-0002-0757-4555 Search for other works by...
Arterial hypertension (HTN) is associated with excess mortality in hypertrophic cardiomyopathy (HCM), but underlying mechanisms are largely elusive. The objective of this study was to investigate the association between HTN and markers left ventricular (LV) dysfunction low-grade systemic inflammation a HCM cohort.
Zusammenfassung Die hypertrophe Kardiomyopathie (HCM) ist die häufigste genetische kardiale Erkrankung mit einer Prävalenz von 0,2–0,6% und ausgeprägten pathologischen, pathophysiologischen klinischen Varianz. Aufgrund der therapeutischen Möglichkeiten stehen bei 70% betroffenen Patient*innen vorhandene dynamische linksventrikuläre Obstruktion seit einigen Jahren in den Vordergrund getretene Hyperkontraktilität im des Interesses. symptomatische, nicht obstruktive HCM wird entsprechend...
Abstract Background Due to its dynamic character, the diagnosis of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) often requires extensive exercise testing. Mitral valve alterations represent structural parameters that are not affected by load or contractility and influence (LVOT) gradients. The residual portion mitral extending past coaptation (RML) has been postulated as a necessity exhibit LVOTO. Purpose This study aims assess impact RML length on...
Abstract Introduction Alcohol septal ablation (PTSMA) was introduced as interventional alternative to surgical myectomy for symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM) 25 years ago. As gender differences in diagnosis and treatment of HOCM are still unclear we analyzed baseline characteristics results PTSMA a large single center cohort respect gender. Methods Between 05/2000 06/2017 first our performed 952 HOCM. We treated less 388 (40.8%) women 564 (59.2%) men....
Abstract Background Arterial hypertension (HTN) is associated with excess mortality in hypertrophic cardiomyopathy (HCM), but underlying mechanisms are largely elusive. Purpose The purpose of this study was to investigate the association between HTN and indices systemic inflammation cardiac function a HCM cohort. Methods This single-center cross-sectional case-control comparing 30 adult patients (HTN+) sex- age-matched without (HTN-). Echocardiographic measures were assessed using...
Abstract Introduction Myocardial work (MW) is an echocardiographic parameter to estimate global and regional myocardial performance. This method utilizes pressure strain loops derived from longitudinal (GLS) left ventricular systolic (LVSP) estimated by brachial blood (BP). Purpose Since LVSP cannot be equated with BP in pts HOCM, we investigated whether the can calculated non-invasively combining Doppler echo parameters BP. estimation mandatory make MW applicable for HOCM-pts. Methods We...
Abstract Introduction and methods Recent registry analyses including the European multicenter (Euro-ASA) documented a favourable long-term outcome of septal ablation (ASA/PTSMA) competitive to surgical myectomy. There is no information about period beyond 10 years. We therefore analyzed in 120 HOCM patients (pts., mean age @ index intervention: 62±13 years) treated with ASA who survived &gt;10 Results Mean CK rise during intervention was 537±258 U/l (reference: &lt;80). A...