A5077349928- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Bioactive Compounds and Antitumor Agents
- Protein purification and stability
- Bacteriophages and microbial interactions
- Solar Radiation and Photovoltaics
- Advanced Thermodynamics and Statistical Mechanics
- Inhalation and Respiratory Drug Delivery
- Solar and Space Plasma Dynamics
University of Colorado Boulder
2023-2024
Protein tyrosine phosphatases (PTPs) are emerging drug targets for many diseases, including cancer, autoimmunity, and neurological disorders. A high degree of structural similarity between their catalytic domains, however, has hindered the development selective pharmacological agents. Our previous research uncovered two unfunctionalized terpenoid inhibitors that selectively inhibit PTP1B over T-cell PTP (TCPTP), PTPs with sequence conservation. Here, we use molecular modeling, supporting...
Abstract Protein tyrosine phosphatases (PTPs) are emerging drug targets for many diseases, including type 2 diabetes, obesity, and cancer. However, a high degree of structural similarity between the catalytic domains these enzymes has made development selective pharmacological inhibitors an enormous challenge. Our previous research uncovered two unfunctionalized terpenoid that selectively inhibit PTP1B over TCPTP, PTPs with sequence conservation. Here, we use molecular modeling experimental...