A5008472468- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Vector-Borne Animal Diseases
- interferon and immune responses
- Energy and Environment Impacts
- Influenza Virus Research Studies
- Inflammasome and immune disorders
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2022-2024
Animal, Santé, Territoires, Risques et Ecosystèmes
2024
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2024
Université de Montpellier
2024
École Pratique des Hautes Études
2022-2024
Université Claude Bernard Lyon 1
2022-2024
Université Paris Sciences et Lettres
2022-2024
University of Geneva
2024
Influenza A virus infection activates the NLRP3 inflammasome, a multiprotein signaling complex responsible for proteolytic activation and release of proinflammatory cytokine IL-1β from monocytes macrophages. Some influenza (IAV) strains encode short 90-amino acid peptide (PB1-F2) on an alternative open reading frame segment 2, with immunomodulatory activity. We recently demonstrated that contemporary IAV PB1-F2 inhibits NLRP3, potentially by NEK7-dependent activation. binds to its C-terminal...
Rift Valley fever virus (RVFV) is a pathogenic arthropod-borne that can cause serious illness in both ruminants and humans. The be transmitted by an arthropod bite or contact with contaminated fluids tissues. Two live-attenuated veterinary vaccines-the Smithburn (SB) Clone 13 (Cl.13)-are currently used during epizootic events Africa. However, their residual pathogenicity (i.e., SB) potential of reversion Cl.13) causes important adverse effects, strongly limiting use the field. In this study,...
Rift Valley fever (RVF) is one of the major viral arthropod-borne diseases in Africa. In recent decades, RVF virus (RVFV), causative agent RVF, has been responsible for multiple outbreaks West Africa with important consequences on human and animal health. particular, an outbreak occurred 2010 after heavy rains desertic region Adrar, Mauritania. It was characterized by appearance severe clinical signs among dromedary camels. Another 2013–2014 across Senegal southern part this study, we two...
Abstract Rift Valley fever (RVF) is one of the major viral arthropod-borne diseases in Africa. In recent decades, RVF virus (RVFV), causative agent RVF, has been responsible for multiple outbreaks West Africa with important consequences on human and animal health. particular, an outbreak occurred 2010 after heavy rainfalls desertic region Adrar, Mauritania. It was characterized by appearance severe clinical signs among dromedary camels. Another 2013-2014 across Senegal southern part this...