A5103786589- Cytomegalovirus and herpesvirus research
- Trypanosoma species research and implications
- Viral-associated cancers and disorders
- Research on Leishmaniasis Studies
- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Hepatitis C virus research
- T-cell and Retrovirus Studies
- Toxin Mechanisms and Immunotoxins
- Herpesvirus Infections and Treatments
- HIV/AIDS oral health manifestations
Fundação Oswaldo Cruz
2025
Universidade Federal do Rio de Janeiro
2025
Universidade Federal de São Paulo
2011
Abstract Background Leishmaniases are neglected tropical diseases with great clinical and epidemiological importance. The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long time, parasite resistance. discovery new therapeutic alternatives is extremely essential, cellular targets a tool that helps in development drugs. Serine proteases emerge important virulence factors Leishmania genus, they participate...
Background/Objectives: The total lysate of Leishmania amazonensis (LaAg) is one the most extensively studied vaccine formulations against leishmaniasis. Despite demonstrating safety and immunogenicity when administered intramuscularly, LaAg has failed to show efficacy in clinical trials and, some cases, even been associated with an enhanced susceptibility infection. Adjuvants, which are molecules or compounds added antigens enhance modulate immune response, frequently employed studies. This...
Background. Clinical and epidemiological data of pandemic influenza A H1N1 infection in solid-organ transplant recipients have been described, but scarce compare these outcomes with nonimmunocompromised patients. Methods. We retrospectively reviewed compared the clinical presentation, morbidity, mortality all kidney (KT) (non-KT) patients admitted for at least 12 hr a diagnosis single hospital complex during 2009 pandemic. Results. There were 22 KT group (29.3%) 53 non-KT (70.7%). The...
INTRODUÇÃO: A emergência do surto pandêmico de influenza A, subtipo H1N1, em abril 2009, representou um grande desafio para a logística saúde pública. Embora maioria dos pacientes infectados apresente manifestações clínicas e evolutivas muito semelhantes às observadas na sazonal, número significativo indivíduos evolui com pneumonia insuficiência respiratória aguda severa. O impacto da infecção pelo vírus imunossuprimidos não é determinado. MÉTODOS: Neste estudo, foram analisadas apresentação...