A5036960099- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Neurological Complications and Syndromes
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Toxicity Studies
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Aortic Disease and Treatment Approaches
- T-cell and B-cell Immunology
- Neonatal skin health care
- Hematopoietic Stem Cell Transplantation
- Bipolar Disorder and Treatment
- Organ and Tissue Transplantation Research
- Dialysis and Renal Disease Management
- Galectins and Cancer Biology
- Pregnancy and Medication Impact
- Biological Research and Disease Studies
- Antibiotics Pharmacokinetics and Efficacy
- Palliative and Oncologic Care
- Complement system in diseases
- CAR-T cell therapy research
- Corneal Surgery and Treatments
- Adenosine and Purinergic Signaling
- Parvovirus B19 Infection Studies
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018-2024
Universidade de São Paulo
2006-2018
Universidade Federal de São Paulo
2002-2012
Hospital do Rim e Hipertensão
2002-2012
Fundação de Apoio à Universidade Federal de São Paulo
2009
Beth Israel Deaconess Hospital
2008
O Sistema Nacional de Transplantes (SNT) Brasileiro coordena e regulamenta o, provavelmente, maior programa transplantes públicos do mundo. Desde o seu estabelecimento, em 1997, número renais aumentou 920 (5,8 pmp), 1988, para 4.630 (24,1 2010. Esse crescimento foi primariamente devido ao aumento no doadores efetivos (de 1,8 pmp 1998 9,3 2010), com correspondente rins transplantados falecidos (3,8 1999 versus 9,9 2010). órgãos vivos não significativamente, 1.065 (6,7 1998, 1.641 (8,6 2010,...
The discard rate of kidneys recovered from deceased donors with acute renal failure (ARF) is higher compared those without ARF mainly due to the uncertainty regarding short-term and long-term outcomes.We retrospectively analyzed 1-year patient, graft, rejection-free survivals function transplantations performed or ARF, defined as serum creatinine level more than 1.5 mg/dL. We multivariable analysis evaluate whether was an independent risk factor associated inferior outcomes.Of a total 1518...
Infectious complications significantly increase morbidity and mortality after renal transplantation. The immunosuppression used is the main risk factor relates directly to incidence severity of infectious events.This a retrospective cohort study, which assessed infections their factors among 1,676 kidney transplant recipients during first year follow-up.Infectious events were observed in 821 (49%) patients. mean number episodes patients with at least one episode was 2.3 (1 -12). most...
There is a growing number of elderly kidney transplant (Ktx) recipients. Elderly recipients present lower acute rejection rates but higher incidence infection and malignancies. Aging per se seems to result in shift memory profile chronic disease (CKD) premature immunological aging. Understanding aging CKD effects on the immune system can improve Ktx immunosuppression. We analyzed system, comparing healthy adults (HAd) (n=14, 26±2y), (HEld) (n=15, 79±7y), end stage renal (ESRD) (EnAd) (n=18,...
Elderly (Eld) (≥60 years) recipients are receiving renal transplants more frequently. The pharmacokinetics (PK) studies of immunosuppressive drugs in healthy volunteers, rarely, include old patients.We studied 208 12-hour tacrolimus (TAC) PK (0, 20, 40, 60, 90, 120, 180, 240, 360, 480, 600, 720 min) 44 Eld (65 ± 3 and compared the results with 31 younger controls (Ctrl) (35 6 recipients, taking oral TAC/mycophenolate sodium (MPS)/prednisone, at 4 different timepoints: PK1 (8 2 days; n = 72),...
Background. Intellectual disability (ID) in patients with chronic kidney disease is a relative contraindication for transplantation. Methods. We analysed retrospective cohort of 16 recipients transplantation ID and 83 controls. Results. Graft survival at 5 years was similar between (81.2%) controls (80.2%), P = 0.9. Patient lower among (81.2% versus 94.4%, < 0.05). Patients had more infection episodes, but no risk factors were identified. Conclusion. Although have long-term patient survival,...
Abstract Equations to estimate glomerular filtration rate ( eGFR ) were developed in patients using the variables age, body weight, and serum creatinine, which may be different elderly. Elderly renal transplant EG ; n=70; mean age 65 ± 4 y) who measured plasma 51 Cr‐ EDTA ‐Clearance mGFR had compared obtained by Cockcroft–Gault corrected surface area CG ‐ BSA ), modification of diet disease MDRD ‐4), Berlin Initiative Study BIS ‐1), chronic kidney epidemiology collaboration CKD EPI )....
Although the proportion of elderly patients among renal transplant recipients has increased, pharmacokinetic (PK) studies immunosuppressants rarely include older patients.We studied 12-hour everolimus (EVL) PK in 16 (all whites; 10 men; mean age, 64 ± 2 years (61-71 years), 4 separate timepoints (at 7, 30, 60, and 150 days) after EVL introduction, corresponding to a postrenal transplantation day: PK1 (43 days), PK2 (65 7 PK3 (106 17 PK4 (206 40 days). Patients received (target trough level...
INTRODUÇÃO: A emergência do surto pandêmico de influenza A, subtipo H1N1, em abril 2009, representou um grande desafio para a logística saúde pública. Embora maioria dos pacientes infectados apresente manifestações clínicas e evolutivas muito semelhantes às observadas na sazonal, número significativo indivíduos evolui com pneumonia insuficiência respiratória aguda severa. O impacto da infecção pelo vírus imunossuprimidos não é determinado. MÉTODOS: Neste estudo, foram analisadas apresentação...
SUMMARY The buttonhole technique of access needle insertion into a single selected site in the arteriovenous fistula has proved to be reliable alternative older methods due its overall low complication rates. Although use blunt needles improves technique, success rate cannulation with these is difficult predict. We analysed short‐term outcome 16 patients receiving in‐centre haemodialysis and compared clinical relevant parameters between without failure. Our dialysis unit treats about 180...
OBJETIVO: O transplante pâncreas-rim é efetivo para pacientes com doença renal crônica terminal e diabetes mellitus insulino-dependente. A função retardada do enxerto pancreático condição frequente exercendo impacto significativo nos resultados em curto prazo dos transplantes pâncreas-rim. objetivo foi analisar o da no MÉTODOS: Análise retrospectiva de 180 receptores pâncreas-rim, incluindo dados demográficos doadores receptores, a reatividade contra painel, incidência rejeição aguda as...
Non-expanded deceased donors with acute kidney failure can be a safe option to increase the number of kidneys for transplantation. Histological evaluation is fundamental establish functional prognosis those grafts. Two transplantations were performed from young donor severe and no structural change in renal parenchyma. Both patients had postoperative delayed graft function, but one them, who good initial urinary volume, required dialysis. Adequate function was present at day 30 after Severe...
INTRODUÇÃO: Terapias de indução são usualmente utilizadas em receptores sensibilizados contra antígenos HLA, retransplantes e pacientes com risco apresentar função tardia do enxerto (FTE). MÉTODO: Estudo retrospectivo objetivo avaliar os desfechos transplante renal doador falecido que receberam alentuzumabe (n = 9). Os grupo controle, pareados conforme idade receptor, tempo diálise isquemia fria, timoglobulina 18). RESULTADOS: Não houve diferença nas características demográficas entre...