A5063465843- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Bipolar Disorder and Treatment
- HIV/AIDS drug development and treatment
- Organ Transplantation Techniques and Outcomes
- Poisoning and overdose treatments
- Bone health and treatments
- Clinical Laboratory Practices and Quality Control
- Epilepsy research and treatment
- Organ Donation and Transplantation
- Sepsis Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Antibiotic Resistance in Bacteria
- Drug-Induced Ocular Toxicity
- Blood disorders and treatments
- Cancer Treatment and Pharmacology
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neurological Complications and Syndromes
- Dialysis and Renal Disease Management
- Antibiotic Use and Resistance
- Potassium and Related Disorders
- Respiratory Support and Mechanisms
- Oral and gingival health research
- Complement system in diseases
Universidade de São Paulo
2004-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
1999-2023
Hospital de Clínicas
2021
Microsoft (Brazil)
2002
New Valve Technology (Germany)
2002
University of New Orleans
2002
Cyclosporin A (CsA) is a potent immunosuppressant that has many side effects, including hypertrichosis, gingival hyperplasia, and tremor. To evaluate whether there relationship between the CsA-pharmacokinetics (PK) these their presence intensity were observed in 46 renal transplanted children/adolescents during two regular visits, occurrence of effects was correlated with CsA-PK. CsA doses had been unchanged for at least 6 mo. blood concentrations measured time 0, 1, 2, 4 h after morning...
Elderly (Eld) (≥60 years) recipients are receiving renal transplants more frequently. The pharmacokinetics (PK) studies of immunosuppressive drugs in healthy volunteers, rarely, include old patients.We studied 208 12-hour tacrolimus (TAC) PK (0, 20, 40, 60, 90, 120, 180, 240, 360, 480, 600, 720 min) 44 Eld (65 ± 3 and compared the results with 31 younger controls (Ctrl) (35 6 recipients, taking oral TAC/mycophenolate sodium (MPS)/prednisone, at 4 different timepoints: PK1 (8 2 days; n = 72),...
Objectives It is unknown if hydroxychloroquine blood level dynamics impact flare rates in lupus nephritis patients. We prospectively evaluated levels to determine which blood-based patterns are more associated with disease activity. Methods In total, 82 patients under a prescribed dose of 4–5.5 mg/kg actual body weight (maximum 400 mg/day) for ≥3 months were at baseline and 7 months. Hydroxychloroquine determined by liquid chromatography-tandem mass spectrometry. Flare was defined as...
INTRODUCTION: This paper presents the failure modes and effects analysis (FMEA) tool in a clinical laboratory through introduction of new technology for blood gas serum ionized calcium multi-parameter analyzers such as Point Care Testing (POCT). OBJECTIVE: To present FMEA risk managing improvement with technologies public laboratory. METHODS: The change multiparameter analyzer type POCT was defined described process. Subsequently, criteria were presented to assessment its quantification. We...
Although the proportion of elderly patients among renal transplant recipients has increased, pharmacokinetic (PK) studies immunosuppressants rarely include older patients.We studied 12-hour everolimus (EVL) PK in 16 (all whites; 10 men; mean age, 64 ± 2 years (61-71 years), 4 separate timepoints (at 7, 30, 60, and 150 days) after EVL introduction, corresponding to a postrenal transplantation day: PK1 (43 days), PK2 (65 7 PK3 (106 17 PK4 (206 40 days). Patients received (target trough level...
Some studies have reported a decreased absorption of mycophenolic acid (MPA) from mycophenolate mofetil (MMF) in renal transplanted (RTx) patients under proton-pump inhibitors (PPIs). There is still lack information regarding (1) whether this effect occurs when MMF administered with either tacrolimus or cyclosporine A [calcineurin (CNIs)], (2) the has same amplitude during first year after RTx, and finally (3) decrease exposure clinically relevant.We retrospectively analyzed omeprazole 348...
Abstract: Background: There is little information regarding the 12‐h mycophenolic acid (MPA) pharmacokinetics (PK), a way to monitor drug and need of frequent monitoring, in stable patients. Methods: A cohort 35 adults, under long‐term mycophenolate mofetil (MMF) therapy plus cyclosporin (n = 12), TACimus 12) or MMF only 11); all with prednisone had MPA‐PK performed ascertain percentage them within defined therapeutic window. In 13 other patients, two PK studies undergone 1 wk apart were...
New cyclosporine A (CsA) formulations must prove their bioequivalence to Neoral®, the reference CsA formulation, allow free prescription for patients. The aim of this study was compare pharmacokinetics (PK) a new formulation (Zinograf-ME), produced by Strides-Arcolab, Neoral and demonstrate interchangeability in stable renal transplant recipients. Twelve-hour PK studies were obtained from 18 (13 M/5 F) adult patients (mean age 44.7 ± 12 years). They received allografts 13 cadaver 5 living...
Abstract Background Hydroxychloroquine (HCQ) blood levels are used to monitor efficacy, safety, and patient adherence during treatment. Oral fluid has emerged as an alternative noninvasive, easily accessible, low-complexity matrix for drug monitoring. However, there is no analytical method measure HCQ in oral fluid. Therefore, we developed validated ultra-high-performance liquid chromatography-tandem mass (UHPLC-MS/MS) the measurement of its main metabolites compared whole blood. Methods Ten...
O artigo apresenta os princípios conceituais sobre desenvolvimento sustentável, sustentabilidade e avalia a evolução impactos na economia, no meio ambiente sociedade. Discutem-se aplicabilidade dos conceitos de empresarial medicina laboratorial desafios inerentes à implantação laboratório clínico. impacto indicadores seu papel processo gestão também são analisados criticamente sob ótica do balanço socioambiental. texto ainda algumas ferramentas para avaliação interpretação sua aplicação...
Introduction:In view of the growing challenge to use antimicrobials for adequate and effective therapy hospital infections, international health agencies have reinforced that it is urgent combat bacterial resistance in preventing development multidrug-resistant (MDR) strains.There has been a significant increase minimum inhibitory concentration (MIC) most available prescribed therapeutic agents against pathogens based on reports this occurrence by infection control committees.Currently,...
Introduction: Septic shock is one of the leading causes death among critically ill patients in Intensive Care Unit (ICU), including severely major burned patients. Rapid diagnosis and early initiation effective antimicrobial therapy are main challenges. The role leukocytes as neutrophil/lymphocyte ratio (NLR) various systemic inflammatory indices, include serum levels interleukin-6 (IL-6), procalcitonin (PCT) c-reactive protein (c-RP) informative laboratory markers this regard respect....
ABSTRACT Background Pathophysiological changes post‐liver transplantation impact the pharmacokinetics and pharmacodynamics of antibiotics. Piperacillin, often used in combination with tazobactam, is a key antibiotic after to its broad‐spectrum activity, but there lack specific pharmacokinetic data this population. This study aims describe parameters target attainment piperacillin pediatric liver transplant recipients. Methods Patients preserved renal function (estimated glomerular filtration...
Factor H (FH) is one of the most important regulatory proteins alternative pathway complement system. FH deficiency a rare condition that causes unregulated C3 consumption, leading to an increased susceptibility infections and glomerulopathies. Our previous studies have demonstrated deficient patient carrying c.452G > A, p.R127H mutation which leads misfolded protein its retention in endoplasmic reticulum. In his cultured fibroblasts, FH-delayed secretion was partially rescued when treated...
Introduction:The results of blood gas analysis using different instrumentation can vary widely due to the methodological differences, calibration procedures and use configurations for each type instrument.Objective:The objective this study was evaluate multiple analytical systems measurement gases, electrolytes metabolites in accordance with accreditation program (PALC) Sociedade Brasileira de Patologia Clinica/Medicina Laboratorial (SBPC/ML).Materials methods:20 samples were evaluated three...
P242 Current issues in drug monitoring point to a phenomenon known as time-dependent concentration, which is the increase blood levels through time despite fixed doses of drugs. Data regarding MMF show that there progressive mycophenolic acid (MPA) concentration first 3 weeks post-tx but therapeutic are reached by third month. The MoDIFY study (Modification Doses Improve Function Years) prospective, randomized compares low trough (C0) tacrolimus (TAC) + 2g/d (Group 1) regular C0 TAC 1500...
Background: Enteric-coated mycophenolate sodium is frequently used in renal transplantation. The pharmacokinetic profile of mycophenolic acid (MPA) shows a broad range time-to-maximum concentration (T max ) that limits the use single MPA to calculate area under time–concentration curve (AUC). For both research and clinical monitoring, measuring complete AUC troublesome center patients. Methods: We obtained 171 MPA-AUC 12h (0, 20, 40, 60, 90, 120, 180, 240, 360, 480, 600, 720 minutes) from 59...