A5101725956- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Renal Transplantation Outcomes and Treatments
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Phagocytosis and Immune Regulation
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic function and diabetes
- Neuroendocrine Tumor Research Advances
- Cardiac tumors and thrombi
- Thyroid Cancer Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Prostate Cancer Treatment and Research
- HIV/AIDS drug development and treatment
- Biomedical Research and Pathophysiology
- Dialysis and Renal Disease Management
- Cancer Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Ultrasound in Clinical Applications
- Cancer Mechanisms and Therapy
- Microscopic Colitis
- Abdominal vascular conditions and treatments
- Protein Kinase Regulation and GTPase Signaling
Centre de Recherche en Cancérologie de Toulouse
2019-2024
Centre National de la Recherche Scientifique
2020-2023
Inserm
2018-2023
Université de Toulouse
2019-2023
Hospital Universitario Reina Sofía
2008-2022
Hospital Reina Sofía de Murcia
2016-2022
Université Toulouse III - Paul Sabatier
2018-2021
ideXlab (France)
2021
Laboratoire Excell
2018
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
Article25 May 2021Open Access Transparent process Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component Benoit Thibault orcid.org/0000-0003-3250-1988 Centre de Recherches en Cancérologie Toulouse, Inserm, CNRS, Université France LABEX TouCAN, These authors contributed equally to this work Search for more papers by author Fernanda Ramos-Delgado Elvire Pons-Tostivint Nicole Therville Celia Cintas Silvia Arcucci Stephanie Cassant-Sourdy Gabriela...
Elderly (Eld) (≥60 years) recipients are receiving renal transplants more frequently. The pharmacokinetics (PK) studies of immunosuppressive drugs in healthy volunteers, rarely, include old patients.We studied 208 12-hour tacrolimus (TAC) PK (0, 20, 40, 60, 90, 120, 180, 240, 360, 480, 600, 720 min) 44 Eld (65 ± 3 and compared the results with 31 younger controls (Ctrl) (35 6 recipients, taking oral TAC/mycophenolate sodium (MPS)/prednisone, at 4 different timepoints: PK1 (8 2 days; n = 72),...
Although the proportion of elderly patients among renal transplant recipients has increased, pharmacokinetic (PK) studies immunosuppressants rarely include older patients.We studied 12-hour everolimus (EVL) PK in 16 (all whites; 10 men; mean age, 64 ± 2 years (61-71 years), 4 separate timepoints (at 7, 30, 60, and 150 days) after EVL introduction, corresponding to a postrenal transplantation day: PK1 (43 days), PK2 (65 7 PK3 (106 17 PK4 (206 40 days). Patients received (target trough level...
Rapid, easy and early pancreatic cancer diagnosis therapeutic follow up continue to necessitate an increasing attention towards the development of effective treatment strategies for this lethal disease. The non invasive quantitative assessment heterogeneity is limited. Here, we report a preclinical imaging protocol using ultrasonography shear wave technology in experimental situ model measure evolution rigidity. Methods: Intrapancreatic tumors were genetically induced by mutated Kras p53 KPC...
The clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD) usually appear in adulthood, however pediatric series report a high morbidity. objective the study was to analyze characteristics ADPKD young adults.Family history, hypertension, albuminuria, estimated glomerular filtration rate (eGFR) and imaging tests were examined 346 adults (18-30 years old) out 2521 patients Spanish registry (REPQRAD). A literature review searched for reports on hypertension with more...
The PI3K pathway is highly active in human cancers. four class I isoforms of are activated by distinct mechanisms leading to a common downstream signaling. Their redundancy thought be responsible for treatment failures inhibitors. We challenged this concept, mapping the differential phosphoproteome evolution response inhibitors with different isoform-selectivity patterns pancreatic cancer, disease currently without effective therapy. In signal was shown control cell proliferation. compared...
Abstract The PI3K pathway is highly active in human cancers. four class I isoforms of are activated by distinct mechanisms leading to a common downstream signaling. Their redundancy thought be responsible for treatment failures inhibitors. We challenged this concept, mapping the differential phosphoproteome evolution response inhibitors with different isoform selectivity patterns pancreatic cancer, disease currently without effective therapy. In signal was shown control cell proliferation....
Background: Enteric-coated mycophenolate sodium is frequently used in renal transplantation. The pharmacokinetic profile of mycophenolic acid (MPA) shows a broad range time-to-maximum concentration (T max ) that limits the use single MPA to calculate area under time–concentration curve (AUC). For both research and clinical monitoring, measuring complete AUC troublesome center patients. Methods: We obtained 171 MPA-AUC 12h (0, 20, 40, 60, 90, 120, 180, 240, 360, 480, 600, 720 minutes) from 59...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a paradigmatic model of micrometastatic disease, characterized by both relapse surgery and failure long-term disease control with chemotherapies in resected, locally advanced unresectable metastatic patients. Molecular characterization large cohorts PDAC patients failed to identify actionable pathways associated mutations except for oncogenic Kras, found more than 80% all Class I PI3K being key regulator cell survival migration, we...