A5023846413- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Pharmacological Effects and Toxicity Studies
- Bipolar Disorder and Treatment
- Fungal Infections and Studies
- Biosimilars and Bioanalytical Methods
- Thermal Regulation in Medicine
- Cancer Treatment and Pharmacology
- Antibiotic Use and Resistance
- Clinical Laboratory Practices and Quality Control
- Antifungal resistance and susceptibility
- Bacterial Identification and Susceptibility Testing
- Multiple Myeloma Research and Treatments
- Respiratory Support and Mechanisms
- Quality and Safety in Healthcare
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Mycology
- Sepsis Diagnosis and Treatment
Universidade de São Paulo
2016-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018-2023
INTRODUCTION: This paper presents the failure modes and effects analysis (FMEA) tool in a clinical laboratory through introduction of new technology for blood gas serum ionized calcium multi-parameter analyzers such as Point Care Testing (POCT). OBJECTIVE: To present FMEA risk managing improvement with technologies public laboratory. METHODS: The change multiparameter analyzer type POCT was defined described process. Subsequently, criteria were presented to assessment its quantification. We...
Although the proportion of elderly patients among renal transplant recipients has increased, pharmacokinetic (PK) studies immunosuppressants rarely include older patients.We studied 12-hour everolimus (EVL) PK in 16 (all whites; 10 men; mean age, 64 ± 2 years (61-71 years), 4 separate timepoints (at 7, 30, 60, and 150 days) after EVL introduction, corresponding to a postrenal transplantation day: PK1 (43 days), PK2 (65 7 PK3 (106 17 PK4 (206 40 days). Patients received (target trough level...
Introduction:In view of the growing challenge to use antimicrobials for adequate and effective therapy hospital infections, international health agencies have reinforced that it is urgent combat bacterial resistance in preventing development multidrug-resistant (MDR) strains.There has been a significant increase minimum inhibitory concentration (MIC) most available prescribed therapeutic agents against pathogens based on reports this occurrence by infection control committees.Currently,...
Introduction: Septic shock is one of the leading causes death among critically ill patients in Intensive Care Unit (ICU), including severely major burned patients. Rapid diagnosis and early initiation effective antimicrobial therapy are main challenges. The role leukocytes as neutrophil/lymphocyte ratio (NLR) various systemic inflammatory indices, include serum levels interleukin-6 (IL-6), procalcitonin (PCT) c-reactive protein (c-RP) informative laboratory markers this regard respect....
ABSTRACT Background Pathophysiological changes post‐liver transplantation impact the pharmacokinetics and pharmacodynamics of antibiotics. Piperacillin, often used in combination with tazobactam, is a key antibiotic after to its broad‐spectrum activity, but there lack specific pharmacokinetic data this population. This study aims describe parameters target attainment piperacillin pediatric liver transplant recipients. Methods Patients preserved renal function (estimated glomerular filtration...
Aims: To validate an SPE-ultra-HPLC-MS/MS method for thalidomide (THD) measurement in dried plasma spot (DPS). Methods: Extraction included acetonitrile/water clean-up and online SPE. The LOD, LLOQ, linearity, precision, accuracy, recovery, matrix effect, process efficiency, carryover, stability, drug interference dilution integrity were assessed. Results: was linear from 50 to 2000 ng/ml with a LOD of 20 LLOQ ng/ml. coefficient variation precision 0.4-7.9% intra-assay 1.3-8.9% interassay,...