A5026979453- Platelet Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Reproductive Biology and Fertility
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Sexual function and dysfunction studies
- Periodontal Regeneration and Treatments
- Sperm and Testicular Function
- Urological Disorders and Treatments
- Ovarian function and disorders
- Obstructive Sleep Apnea Research
- Blood transfusion and management
Hull York Medical School
2017-2021
University of Hull
2017-2021
The prospect of ovarian rejuvenation offers the tantalising treating age-related declines in fertility or pathological conditions such as premature failure. concept was invigorated by indication existence oogonial stem cells (OSCs), which have been shown experimentally to ability differentiate into functional follicles and generate oocytes; however, their clinical potential remains unknown. Furthermore, there is now growing interest performing situ. One proposed approach involves injecting...
Prostacyclin (PGI2) modulates platelet activation to regulate haemostasis. Evidence has emerged suggest that thrombi are dynamic structures with distinct areas of differing activation. It was hypothesised PGI2 could reverse spreading by actin cytoskeletal modulation, leading reduced capability aggregates withstand a high shear environment. Our data demonstrates post-flow over activated and spread platelets on fibrinogen, identified significant reduction in surface area under shear....
Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation and inhibition. We hypothesised Nitric oxide (NO), a inhibitor, can modulate the actin cytoskeleton reversing spreading, therefore reduce capability withstand high shear environment. Our data demonstrates GSNO, DEANONOate, PKG-activating cGMP analogue reversed stress fibre formation increased nodule in adherent platelets. This effect is sGC dependent independent ADP...
Investigating human platelet function in low-oxygen environments is important multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing blood from which platelets are isolated analysed at atmospheric conditions or re-exposed to low oxygen levels chambers before testing. However, it remains unknown how the vitro handling of samples itself changes their dissolved concentration, might...