A5044932735- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Radiation Detection and Scintillator Technologies
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Clinical Laboratory Practices and Quality Control
- Particle physics theoretical and experimental studies
- Neutrino Physics Research
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Diet, Metabolism, and Disease
- Brain Metastases and Treatment
- Herpesvirus Infections and Treatments
- Lipoproteins and Cardiovascular Health
- Air Quality and Health Impacts
- Acute Lymphoblastic Leukemia research
- Meta-analysis and systematic reviews
- Statistical Methods in Clinical Trials
University of Bristol
1974-2025
University of Oxford
1997-2023
Queen Elizabeth Hospital Birmingham
2016-2023
University of Birmingham
2008-2023
University Hospitals Birmingham NHS Foundation Trust
2008-2023
Cheltenham Festivals
2019
Alder Hey Children's NHS Foundation Trust
2008-2013
Alder Hey Children's Hospital
1980-2013
University of Liverpool
1980-2013
Selly Oak Hospital
2006
<h3>Abstract</h3> <b>Objective:</b> To evaluate baseline risk factors for coronary artery disease in patients with type 2 diabetes mellitus. <b>Design:</b> A stepwise selection procedure, adjusting age and sex, was used 2693 subjects complete data to determine which should be included a Cox proportional hazards model. <b>Subjects:</b> 3055 white (mean 52) recently diagnosed mellitus without evidence of related atheroma. Median duration follow up 7.9 years. 335 developed within 10 <b>Outcome...
People with type 2 diabetes are at elevated risk of stroke compared those without diabetes. Relative risks have been examined in earlier work, but there is no readily available method for predicting the absolute a diabetic individual. We developed mathematical models to estimate first using data from 4549 newly diagnosed patients enrolled UK Prospective Diabetes Study.During 30 700 person-years follow-up, 188 strokes (52 fatal) occurred. Model fitting was carried out by maximum likelihood...
Maturity-onset diabetes of the young (MODY) type 3 is a dominantly inherited form diabetes, which often misdiagnosed as non-insulin-dependent mellitus (NIDDM) or insulin-dependent (IDDM). Phenotypic analysis members from four large Finnish MODY3 kindreds (linked to chromosome 12q with maximum lod score 15) revealed severe impairment in insulin secretion, was present also those normoglycemic family who had gene. In contrast patients NIDDM, did not show any features resistance syndrome. They...
Abstract Background: The American Diabetes Association task force on standardization of insulin assays in 1996 showed wide variation assay bias. Newer are specific for insulin, with several now available automated immunoassay analyzers. Methods: In 2004, we compared 11 commercially by analyzing 150 serum samples (99 fasting/51 postprandial) from study participants various degrees glucose intolerance (exclusions being type 1 diabetes, treatment, or presence antibodies). All were calibrated...
The biological variation of some commonly assessed metabolic variables in healthy subjects has not been studied extensively. aim the study was to assess, 12 (6 male and 6 female; mean (SD) age; 22.7 (1.5) years) following an overnight fast, day-to-day body fat (impedance method), triglycerides, nonesterified fatty acid (NEFAs), glycerol, 3-hydroxybutyrate (3-OHB), lactate, glucose, insulin (RIA), C-peptide, glucagon on consecutive days.Between- within-subject coefficients (CVG CVW) were...
In this letter we report the first scientific result based on antineutrinos emitted from BR2 reactor at SCK CEN. The SoLid experiment uses a novel type of highly granular detector whose basic detection unit combines two scintillators, PVT and 6LiF:ZnS(Ag), to measure via their inverse-beta-decay products. An advantage is its linear response as function deposited particle energy. full-scale comprises 12800 voxels operates over very short 6.3--8.9 m baseline core. segmentation 3D imaging...
The effects of Ni(2+) on the release amylase from rat parotids, insulin mouse pancreatic islets and growth hormone bovine pituitary slices were investigated. In all these secretory systems, was shown to inhibit evoked by a variety stimuli both physiological pharmacological. Measurements rates substrate oxidation tissue concentrations ATP 3':5'-cyclic AMP suggest that this inhibitory action does not arise through an effect energy metabolism or cyclic metabolism. It is concluded although some...
SUMMARY Aims To assess the effect of diet on fasting plasma lipids and lipoproteins in patients with newly diagnosed Type 2 diabetes. Methods A total 2906 each underwent 3 months' therapy before allocation to a randomized controlled clinical trial. Lipids were measured at diagnosis after diet. Results The mean body weight was 83 kg. Weight decreased by 4.5 kg; mass index (BMI) 1.51 kg/m ; glucose fell mmol/l from 11 mmol/l; HbA 1c 2% 9%. Triglyceride concentrations reduced men −0.41 (95%...
Abstract Aims To explore whether a quantitative approach to identifying hospitalized patients with diabetes at risk of hypoglycaemia would be feasible through incorporation routine biochemical, haematological and prescription data. Methods A retrospective cross‐sectional analysis all diabetic admissions ( n =9584) from 1 January 2014 31 December was performed. Hypoglycaemia defined as blood glucose level <4 mmol/l. The prediction model constructed using multivariable logistic regression,...
Abstract Aim To determine whether glycated haemoglobin (HbA 1c ) can be used in combination with fasting plasma glucose (FPG) for the diagnosis of diabetes patients impaired (IFG) and a broader spectrum patients. Methods An algorithm was derived from oral tolerance test (OGTT) capillary samples 500 consecutive UK IFG by World Health Organization criteria. It validated further and, venous specimens, 1175 unselected Australian Results The derivation cohort aged 61 years (50–69 years) (median...
This randomized crossover double-blind placebo-controlled study aimed to assess the efficacy of nateglinide (A-4166), a novel phenylalanine-derived insulin secretagogue, in type 2 diabetic subjects while fasting and 5 min before standard meal.A single dose (60, 120, or 180 mg) placebo was given eight diet-treated overnight-fasted patients seven breakfast. Plasma glucose, radioimmunoassay insulin, were measured at baseline for further min.The time-averaged 180-min postdose mean decrease...
OBJECTIVE—We investigated how β-cell function and insulin sensitivity or resistance are affected by the type of blood sample collected choice assay homeostatis model assessment (HOMA) calculator (http://www.dtu.ox.ac.uk). RESEARCH DESIGN AND METHODS—Insulin was measured using 11 different assays in serum 1 heparinized plasma. Fasting subjects with normoglycemia (n = 12), pre-diabetes, i.e., impaired fasting glucose tolerance 18), 2 diabetes 67) were recruited. Patients treated those who...
Abstract The effects of storage for 6 months or 2 years at -20 degrees C were studied in urine samples from Type II diabetic patients by assaying albumin immunoturbidity, N-acetylglucosaminidase (EC 3.2.1.30) methoxynitrovinylphenol release, and creatinine the Jaffé method. There significant decreases (P &lt; 0.001) albumin/creatinine ratios 1.14 (0.63-2.98) to 0.83 (0.32-2.12) g/mol (median + interquartile ranges) after (n = 97), 1.64 (0.74-5.72) 1.00 (0.37-4.54) 89). percentage with...
<h3>Objectives</h3> To describe postexposure prophylaxis (PEP) against varicella zoster virus (VZV) in children being treated for malignancy the UK and Ireland: population at risk, frequency of exposure, clinical practice attitudes among healthcare providers. <h3>Design</h3> An observational study three parts: (1) a retrospective survey serostatus diagnosis malignancy, (2) collation immune globulin (VZIG) dispensing data over 3-year period (3) an online paediatric oncologists9 beliefs...
Abstract HbA(1c) is recommended for monitoring glycaemic control and quantifying the risk of complications in patients with diabetes. National guidelines treatment diabetes UK specify that measurements should be Diabetes Control Complications Trial (DCCT)-aligned i.e. comparable to DCCT Prospective Study (UKPDS). The IFCC reference method will introduced Europe December 2003 calibration all laboratory POCT (point care testing) methods following recent EC "In Vitro Diagnostic" (IVD)...