A5008838737- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Catalysis for Biomass Conversion
- RNA modifications and cancer
- Virus-based gene therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Transplantation: Methods and Outcomes
- Nanopore and Nanochannel Transport Studies
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Enzyme Catalysis and Immobilization
- Biodiesel Production and Applications
- Advanced Nanomaterials in Catalysis
University of Kentucky
2016-2017
National Center for Agricultural Utilization Research
2011
United States Department of Agriculture
2011
Agricultural Research Service
2011
Small interfering RNA (siRNA) inhibits specific gene expression in cells to treat genetic diseases including cancer, but siRNA-based cancer therapy is often hindered by inefficient siRNA delivery tumor. Poly(ethylene glycol)-conjugated poly(ethylene imine) (PEG-PEI) widely studied as a promising carrier. PEG-PEI can form ion complexes with and enhance silencing (transfection) due its high buffering capacity. However, the transfection efficacy of formulations changes variable polymer...
Despite effective gene silencing in vitro, vivo delivery and transfection of siRNA remain challenging due to the lack carriers that protect stably body. This study is focused elucidate correlation between complex stability efficiency carriers. The were prepared by using polymer nanoassemblies made a cationic branched [poly(ethylene imine): bPEI] which hydrophilic poly(ethylene glycol) polymers tethered covalently. These (TNAs) further modified with lipophilic chains (palmitate: PAL) core...
Abstract With the objective of expanding number functionalized lipids available, reactive vinyl group acrylic acid was introduced to triacylglycerol by esterification glycerol. Didecanoylacryloylglycerol synthesized from decanoic and acids glycerol using K 2 O as catalyst. g (21.7 mmol) glycerol, 11.3 (65.4 acid, 6.2 (86.1 60 ml hexane, 400 mg were added 300‐ml closed stainless steel reactor maintained at 200 °C for 5 h. The resulting product, designated DDA, isolated about 40% yield based...