A5070117979- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Muscle activation and electromyography studies
- Lower Extremity Biomechanics and Pathologies
- Spinal Cord Injury Research
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Orthopaedic implants and arthroplasty
- Prosthetics and Rehabilitation Robotics
- Shoulder Injury and Treatment
- Extracellular vesicles in disease
- Musculoskeletal pain and rehabilitation
- Nerve Injury and Rehabilitation
- Pelvic and Acetabular Injuries
- Stroke Rehabilitation and Recovery
- Hip disorders and treatments
- Mechanical Engineering and Vibrations Research
- Adipose Tissue and Metabolism
- Medical Imaging and Analysis
- Orthopedic Surgery and Rehabilitation
- Bone Metabolism and Diseases
- Musicians’ Health and Performance
- Cervical and Thoracic Myelopathy
- Bone health and osteoporosis research
Finland University
2018-2025
University of Eastern Finland
2017-2025
Amirkabir University of Technology
2016-2018
Isfahan University of Technology
2012-2013
Islamic Azad University of Najafabad
2013
Islamic Azad University, Isfahan
2013
This study investigated relationships between fatty acid (FA) profiles of extracellular vesicles (EVs) and cartilage degradation, functional limitations, pain, psychological well-being in knee osteoarthritis (KOA). Fasting plasma was collected from controls (n = 10), end-stage KOA patients at baseline 12) 3 12 months 11 9) after joint replacement surgery, synovial fluid (SF) 10). EVs were isolated with the exoEasy Maxi Kit or size-exclusion chromatography, EV FAs analyzed gas...
Abstract Abnormal mechanical loading is essential in the onset and progression of knee osteoarthritis. Combined musculoskeletal (MS) finite element (FE) modeling a typical method to estimate load distribution tissue responses joint. However, earlier combined models mostly utilize static-optimization based MS muscle force driven FE typically use elastic materials for soft tissues or analyze specific time points gait. Therefore, here we develop an electromyography-assisted model with...
Abstract Background Emerging evidence suggests that extracellular vesicles (EVs) can play roles in inflammatory processes and joint degradation primary osteoarthritis (OA), a common age-associated disease. EV subpopulations express tetraspanins platelet markers may reflect OA pathogenesis. The present study investigated the associations between these surface articular cartilage degradation, subjectively objectively assessed pain, functional limitations knee (KOA). Methods Serum EVs were...
Joint tissue mechanics (e.g., stress and strain) are believed to have a major involvement in the onset progression of musculoskeletal disorders, e.g., knee osteoarthritis (KOA). Accordingly, considerable efforts been made develop finite element (MS-FE) models estimate highly detailed that predict cartilage degeneration. However, creating such is time-consuming requires advanced expertise. This limits these complex, yet promising, MS-FE research applications with few participants makes...
Finite element (FE) models have been widely used to investigate knee joint biomechanics. Most of these developed study adult knees, neglecting pediatric populations. In this study, an atlas-based approach was employed develop subject-specific FE the for eight typically developing individuals. Initially, validation simulations were performed at four passive tibiofemoral (TFJ) flexion angles, and resulting TFJ patellofemoral (PFJ) kinematics compared corresponding patient-matched measurements...
Incidence of paediatric anterior cruciate ligament (ACL) ruptures has increased substantially over recent decades. Following ACL rupture, reconstruction (ACLR) surgery is performed to restore knee function. This involves replacing the failed with a graft, however, surgeons must select from range surgical parameters (e.g., type, size, insertion, and pre-tension) no robust evidence guiding these decisions. study used sequentially-linked neuromusculoskeletal (NMSK) finite element (FE) models...
Accurate knowledge of the joint kinematics, kinetics, and soft tissue mechanical responses is essential in evaluation musculoskeletal (MS) disorders. Since vivo measurement these quantities requires invasive methods, finite element (MSFE) models are widely used for simulations. There are, however, limitations current approaches. Sequentially linked MSFE benefit from complex MS FE models; model's outputs independent model calculations. On other hand, due to computational burden, embedded...
Tissue-level mechanics (e.g., stress and strain) are important factors governing tissue remodeling development of knee osteoarthritis (KOA), hence, the success physical rehabilitation. To date, no clinically feasible analysis toolbox has been introduced used to inform clinical decision making with subject-specific in-depth joint different activities. Herein, we utilized a rapid state-of-the-art electromyography-assisted musculoskeletal finite element fibril-reinforced poro(visco)elastic...
Gait modification is a common nonsurgical approach to alter the mediolateral distribution of knee contact forces, intending decelerate or postpone progression mechanically induced osteoarthritis (KOA). Nevertheless, success rate these approaches controversial, with no studies conducted assess alterations in tissue-level mechanics governing cartilage degradation response KOA patients undertaking gait modifications. Thus, here we investigated effect different conventional conditions and...
Background . Osteoarthritis (OA) is a disease which influences the performance of knee joint. Moreover, force and moments applied on joint increase in contrast to normal subjects. Various types orthoses have been designed solve mentioned problems. However, there are other problems terms distal migration during walking alignment orthosis cannot be changed following use brace. Therefore, main aim research was design an aforementioned Method A new type with modular structure. Two patients OA...
Abstract Obesity is a known risk factor for development of osteoarthritis (OA). Numerical tools like finite‐element (FE) models combined with degenerative algorithms have been developed to understand the interplay between OA and obesity. In this study, we aimed predict knee cartilage degeneration in cohort obese adults investigate importance patient‐specific information on predictions. We used validated FE modeling approach three different age‐dependent functions (step‐wise, exponential,...
Introduction: Knee osteoarthritis (KOA) is characterized by articular cartilage degeneration. It has been widely accepted that the mechanical joint environment plays a significant role in onset and progression of this disease. In silico models have used to study interplay between loading degeneration, hereby relying mainly on two key mechanoregulatory factors indicative collagen degradation proteoglycans depletion. These are strain fibril direction (SFD) maximum shear (MSS) respectively....
Fibril-reinforced poroviscoelastic material models are considered state-of-the-art in modeling articular cartilage biomechanics. Yet, parameters often based on bovine tissue properties computational knee joint models, although distinctly different from those of humans. Thus, we aimed to investigate how mechanical responses affected the model during walking when fibril-reinforced human data instead bovine. We constructed a finite element which tibial and femoral cartilages were modeled as...
Abstract Objective To develop and assess an automatic robust knee musculoskeletal finite element (MSK-FE) modeling pipeline. Methods Magnetic resonance images (MRI) were used to train nnU-Net networks for auto-segmentation of bones (femur, tibia, patella, fibula), cartilages patella), menisci, major ligaments. Two different MRI sequences broaden applicability. Next, we created MSK-FE models unseen dataset using two pipelines: template-based auto-meshing. MSK had personalized geometries with...
Abstract Purpose Anterior cruciate ligament (ACL) rupture is increasingly common in paediatric and adolescent populations, typically requiring surgical ACL reconstruction (ACLR) to restore knee stability. However, ACLR substantially alters biomechanics (e.g., motion tissue mechanics) placing the patient at elevated risk of early‐onset osteoarthritis. Methods This study employed a linked neuromusculoskeletal (NMSK)‐finite element (FE) model determine effects four critical parameters (graft...
Stability during standing is achieved by a complex coordination process between various human systems. The stability of normal subjects and patients with neuromuscular disorders has been evaluated common methods based on force plate data analysis for one minute. However, most the people frequently stand prolonged period daily activities.This study aimed to evaluate longer time. Moreover, new method was introduced analyze musculoskeletal disorders.Experimental.Four groups adults children,...
Abstract Degenerative musculoskeletal diseases like osteoarthritis can be initiated by joint injury. Injurious overloading-induced mechanical straining of articular cartilage and subsequent biological responses may trigger degradation. One early sign degradation is loss aggrecan content which potentially accelerated near chondral lesions under physiological loading. Yet, the mechanoinflammatory mechanisms explaining time-dependent in regions with disparate loading are unclear challenging to...
<b><i>Background:</i></b> Postural instability is a common disorder in Parkinson’s disease (PD). The aim of this study was to evaluate stance stability the subjects at early stage PD with both linear and nonlinear approaches. Moreover, aimed find effect visual control on quiet postural these patients. <b><i>Method:</i></b> Seventeen patients (Hoehn/Yahr scale: 1) 17 healthy were instructed maintain 2 conditions (opened eyes closed eyes). Four...