A5090680466- Veterinary Equine Medical Research
- Inflammatory mediators and NSAID effects
- Veterinary Practice and Education Studies
- Veterinary Pharmacology and Anesthesia
- Influenza Virus Research Studies
- Structural Load-Bearing Analysis
- Structural Analysis and Optimization
- Animal Disease Management and Epidemiology
- Animal Behavior and Welfare Studies
- Structural Analysis of Composite Materials
- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Advanced Radiotherapy Techniques
- Structural Behavior of Reinforced Concrete
- Composite Structure Analysis and Optimization
- Gastrointestinal disorders and treatments
- Veterinary Orthopedics and Neurology
- Intestinal and Peritoneal Adhesions
- Pharmacological Effects and Assays
- Technology's Impact on Media
- Engineering Education and Curriculum Development
- S100 Proteins and Annexins
- Mechanics and Biomechanics Studies
- Veterinary medicine and infectious diseases
- Higher Education Governance and Development
Navtech Radar (United Kingdom)
2024
Hewlett Packard Enterprise (United States)
2023
Hewlett-Packard (United States)
2022
Maimonides Medical Center
2022
University of Glasgow
2012-2021
University of Southern Maine
2020
Newmarket Equine Hospital
2016-2020
North Carolina State University
2009-2011
Dartmouth–Hitchcock Medical Center
2005-2011
Oklahoma State University
2007-2009
Abstract Objective —To investigate effects of lidocaine hydrochloride administered IV on mucosal inflammation in ischemia-injured jejunum horses treated with flunixin meglumine. Animals —24 horses. Procedures —Horses received saline (0.9% NaCl) solution (SS; 1 mL/50 kg, [1 dose]), meglumine (1 mg/kg, IV, q 12 h), (bolus [1.3 mg/kg] and constant rate infusion [0.05 mg/kg/min], during after recovery from surgery), or both (n = 6/group). During surgery, blood flow was occluded for 2 hours...
OBJECTIVE To characterize and describe the compensatory load redistribution that results from unilateral hind limb lameness in horses. DESIGN Retrospective case series. ANIMALS 37 client-owned PROCEDURES Medical records were reviewed to identify horses with responded positively (by objective assessment) diagnostic local anesthesia during evaluation evaluated before after an inertial sensor-based diagnosis system. Horses grouped as having only, ipsilateral forelimb lameness, or contralateral...
In order for changes in lameness to be accurately and repeatably detected recorded during diagnostic investigations, an objective measure of is required.To ascertain whether inertial sensor-based system can distinguish between a positive negative response anaesthesia the foot objectively assess effect on trot.Restrospective clinical study.Data obtained investigations undertaken August 2011 December 2012 which either palmar digital or abaxial sesamoid nerve block was performed were...
Summary Objectives: A wireless, inertial sensor‐based system has previously been validated for evaluation of equine lameness. However, threshold values have not determined the assessment responses to flexion tests. The aim this investigation was evaluate a objective response flexion. Methods: Healthy adult horses (n = 17) in work were recruited prospectively. Horses instrumented with sensors on head (accelerometer), pelvis (accelerometer) and right forelimb (gyroscope), before trotting...
Influenza A viruses (IAVs) can jump species barriers and occasionally cause epidemics, epizootics, pandemics, panzootics. Characterizing the infection dynamics at target tissues of natural hosts is central to understanding mechanisms that control host range, tropism, virulence. Canine influenza virus (CIV; H3N8) originated after transfer an equine (EIV) into dogs. Thus, comparing CIV EIV isolates provides opportunity study determinants emergence. Here we characterize replication canine,...
ABSTRACT Influenza A viruses (IAVs) are common pathogens of birds that occasionally establish endemic infections in mammals. The processes and mechanisms result IAV mammalian adaptation poorly understood. viral nonstructural 1 (NS1) protein counteracts the interferon (IFN) response, a central component host species barrier. We characterized NS1 proteins equine influenza virus (EIV), lineage avian origin. showed evolutionarily distinct counteract IFN response using different mutually...
The chief purpose of the present paper is to describe convolutions a Bushwoman’s brain, and also those two smallest human idiot brains yet on record, belonging respectively microcephalic woman boy English parentage. But other points interest, such as weight, size, general form, internal structure these their several parts, are likewise noticed; and, in case idiots, information prefixed could be collected concerning feeble mental bodily powers. attention which has recently been directed study...
There is little knowledge of the prescription nonsteroidal anti-inflammatory drugs (NSAIDs) and whether their varies between countries.To describe practices NSAIDs in equids United Kingdom (UK), States America (USA) Canada.Descriptive observational study.Free-text electronic medical records from 141,543 10 equine UK, 255,777 7 with 20 branches USA 2 Canada were evaluated. A validated text-mining technique was used to proportion prescribed at least once these countries. The choice orthopaedic...
Abstract OBJECTIVE To evaluate ex vivo cyclooxygenase (COX) inhibition and compare in vitro COX-1 by flunixin meglumine firocoxib horses. ANIMALS 4 healthy horses for experiments 12 (6 males 6 females; 5 Thoroughbreds, Warmbloods, 2 ponies) undergoing elective surgery experiments. PROCEDURES received (1.1 mg/kg, IV, q h) or (0.09 24 h). Blood samples were collected before (baseline) hours after NSAID administration. Prostanoids (thromboxane B , prostaglandin E metabolites) served as...
As antimicrobial resistant bacterial strains continue to emerge and spread in human animal populations, understanding prescription practices is key benchmarking current performance setting goals. Antimicrobial (AP) companion veterinary species widespread, but neither monitored nor restricted the USA Canada. The use of certain classes discouraged some countries, hope preserving efficacy for serious infections.The aim this study was ascertain rate a number 'reserved' antimicrobials...
Virus ecology and evolution play a central role in disease emergence. However, their relative roles will vary depending on the viruses ecosystems involved. We combined field studies, phylogenetics experimental infections to document with unprecedented detail stages that precede initial outbreaks during viral emergence nature. Using serological surveys we showed absence of large-scale outbreaks, horses Mongolia are routinely exposed infected by avian influenza (AIVs) circulating among wild...
The purpose of this study was to determine the pharmacokinetics deracoxib following oral administration horses. In addition, in vitro equine whole blood cyclooxygenase (COX) selectivity assays were performed. Six healthy adult horses administered (2 mg/kg) orally. Plasma samples collected prior drug (time 0), and 10, 20, 40 min 1, 1.5, 2, 4, 6, 8, 12, 24, 48 h after for analysis with high pressure liquid chromatography using ultraviolet detection. Following PO administration, had a long...
Summary Newer cyclo‐oxygenase‐2 (COX‐2) selective nonsteroidal anti‐inflammatory drugs (NSAIDs), such as firocoxib, are proposed to reduce inhibition of cyclo‐oxygenase‐1 (COX‐1) and avoid undesirable side effects, while continuing inhibit inflammation associated with COX‐2. However, COX selectivity is typically based on in vitro testing, which may not provide sufficient information critical for treatment selection. This study investigated the pharmacokinetics ex vivo COX‐1 COX‐2...
The use of electronic medical records (EMRs) offers opportunity for clinical epidemiological research. With large EMR databases, automated analysis processes are necessary but require thorough validation before they can be routinely used. aim this study was to validate a computer-assisted technique using commercially available content software (SimStat-WordStat v.6 (SS/WS), Provalis Research) mining free-text EMRs. dataset used the process included life-long EMRs from 335 patients (17,563...
Abstract Objective —To determine the cyclooxygenase (COX) selectivity of robenacoxib and its effect on recovery jejunal mucosa following ischemic injury in horses. Animals —12 healthy Procedures —Half maximal inhibition (EC 50 ) for COX-1 COX-2 activity was established bloods samples from 6 horses via measurement thromboxane B 2 (TXB prostaglandin E concentrations, respectively; COX subsequently calculated. Six other were anesthetized, ischemia induced jejunum hours. Control ischemia-injured...