Hyperthyroidism in pregnancy occurs with a prevalence of 0.05--0.2% and has been shown to affect neonatal outcomes. Fetal weight increases markedly during the third trimester pregnancy. This retrospective study was performed examine effect maternal hyperthyroidism late on birth (NBW).Medical obstetric records 293 pregnant women present past history were retrospectively reviewed.There 188 181 patients adequate data for inclusion analysis. The divided into two groups according thyroid function...

Abstract Dietary phosphorus restriction up-regulates intestinal vitamin D receptor (VDR), but the tissue specificity of up-regulation and mechanism accumulation remain unknown. Therefore, effects low diet (LPD) on VDR content in intestine, kidney, splenic monocytes/macrophages were examined. Male Sprague-Dawley rats weighing 50–100 g fed a normal (NPD; 0.6% Ca, 0.65% P) as controls followed by an LPD (0.6% 0.1% for 1–10 days (D1-D10). rapidly decreased serum P levels D1 from 11.11 ± 0.19...

Previous studies of the treatment hyperthyroidism with a single daily dose antithyroid drugs have demonstrated favourable result methimazole (MMI). However, efficacy propylthiouracil (PTU) was inconsistent. The present prospective randomized study conducted to compare MMI and PTU in induction euthyroidism patients Graves' disease. Seventy‐one newly diagnosed disease were studied. Patients two groups receive once either 15 mg or 150 for 12 weeks. therapeutic determined biochemically by serum...

Six known genes responsible for maturity-onset diabetes of the young (MODY) were analysed to evaluate prevalence their mutations in Thai patients with MODY and early-onset type 2 diabetes.Fifty-one unrelated probands diabetes, 21 them fitted into classic criteria, nucleotide variations promoters, exons, exon-intron boundaries six genes, including HNF-4alpha, GCK, HNF-1alpha, IPF-1, HNF-1beta, NeuroD1/beta2, by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP)...

A case-control study was conducted to determine factors involved in foot ulceration Thai non-insulin-dependent (Type 2) diabetic patients. Fifty-five patients with ulcers (42 females and 13 males) 110 without (83 27 were evaluated for 26 possibly associated ulceration. The results showed that had significantly lower knowledge foot-care practice scores; poorer glycaemic control, renal function, visual higher prevalence of retinopathy peripheral neuropathy than ulcers, whereas there no...

Background: High-intensity statin is recommended in high-risk type 2 diabetes (T2D); however, dose dependently increases the risk of developing new-onset diabetes, can potentially worsen glycemic control T2D, and may cause cognitive impairment. This study aimed to investigate effect intensification on glucose homeostasis function T2D. Materials Methods: T2D patients who were taking simvastatin ≤ 20 mg/day randomized continue same dosage (low-dose group; LS, n=63) for 12 weeks, or change...

Dietary P restriction increases renal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] biosynthesis through stimulation of proximal tubule 25-hydroxyvitamin D3-1 alpha-hydroxylase (1-OHase). Because insulin-like growth factor I (IGF-I) is required for 1-OHase by low-P diet (LPD) and because low-Ca parathyroid hormone lost with aging, studies were undertaken to determine whether activity during LPD impaired age IGF-1 can increase in adult rats. Five days increased vitro young (97.3 +/- 13.5 vs. 49.7...

Background . Previous studies used unequal or high daily dosages of methimazole (MMI) to compare the efficacy once dose regimen (OD-MMI) with that divided doses (DD-MMI) in inducing euthyroidism. Objectives To OD-MMI DD-MMI using low dosage MMI Methods Fifty patients clinically nonsevere Graves’ hyperthyroidism were randomized be treated 15 mg/day DD-MMI. Results 21 cases (84%) and 23 (92%) eligible for analyses. During treatment, there was no difference baseline characteristics, serum FT3...

Background: The benefit of sulfonylureas (SUs) to patients with type 2 diabetes mellitus receiving long-term insulin treatment is unclear. This study evaluated glycemic control and beta-cell function after SU withdrawal in these patients. Methods: In this 8-week randomized controlled study, who had been treated for at least 3 years plus moderate high doses SUs were randomly assigned (n=16) or continuation SUs. Clinical characteristics, control, hypoglycemic events, secretion, including...

Low dose statins are commonly used among Asians, because plasma low-density lipoprotein cholesterol (LDL-C) reductions similar to those observed in Westerners achieved at lower doses. We aimed assess the efficacy of low- and moderate-intensity for achieving lipid targets Thai type2 diabetes (T2D) evaluate factors associated with greater LDL-C reduction by statins.T2D patients who were treated Siriraj Diabetes Clinic during January 2013 December 2014 study period eligible inclusion(n = 978),...

Background. The long-term continuation of the low-dose antithyroid drug (ATD) beyond standard duration ATD therapy 12–18 months to prevent recurrent hyperthyroidism (RH) is recommended with low quality evidence. Objectives. To examine whether treatment would provide a benefit in prevention RH patients Graves’ (GH) who achieved euthyroid status course therapy. Methods. A 36-month prospective randomized controlled study was conducted 184 had first diagnosed GH and were treated regimen using...

Introduction: Statin intensification is required in patients who have high-risk for cardiovascular events. However, it unclear if this needed whom plasma LDL-C target was achieved with low-dose statin primary prevention. We investigated the efficacy and safety of switching from to high-intensity among type 2 diabetes (T2D) had < 100 mg/dl treatment. Methods: T2D no atherosclerotic disease level while taking simvastatin ≤ 20 mg/day were randomized continue using same dosage (low-dose group;...

Little is known about the association among skin color, sunlight exposure. and vitamin D status in Southeast Asian population.To investigate between color measured by von Luschan chromatic scale (VLCS) Thai medical ambulatory patients.Medical patients were enrolled. The eligibility criteria as follows: aged >18 years, stable conditions, no conditions directly affecting status. Serum 25-hydroxyvitamin [25(OH)D] levels assessed. Skin at outer forearm was assessed using VLCS which grades from...

The aim of this study was to investigate beta-cell function and examine whether sulfonylureas (SUs) are still useful in patients with type 2 diabetes (T2DM) who failed maintain optimal glycemic control a combination maximum dosages metformin SU.