A5005701590- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Plant chemical constituents analysis
- Synthesis and biological activity
- Genomics, phytochemicals, and oxidative stress
- Phytochemistry and Biological Activities
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plants and Neuroprotection
- Herbal Medicine Research Studies
- Cancer therapeutics and mechanisms
- Bioactive natural compounds
- Bioinformatics and Genomic Networks
- Dermatology and Skin Diseases
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Cell death mechanisms and regulation
- Essential Oils and Antimicrobial Activity
- Neurological Disease Mechanisms and Treatments
- Ginger and Zingiberaceae research
Khon Kaen University
2018-2025
Itching is the most frequent pathology in dermatology that has significant impacts on people's mental health and social life. Transient receptor potential vanilloid 3 (TRPV3) channel a promising target for treating pruritus. However, few selecetive potent antagonists have been reported. This study was designed to identify selective TRPV3 antagonist elucidate its anti-pruritus pharmacology.FlexStation calcium fluorescence imaging were conducted track functional compounds. Whole-cell patch...
Alzheimer’s disease (AD), a growing global challenge, lacks effective preventive and therapeutic strategies. This study explored the promising potential of Kaempferia parviflora (KP) its methoxyflavones (MFs) against disease. We evaluated KP extract five MFs for antioxidant capacity, cholinesterase inhibition (AChE, BChE), amyloid plaque (Aβ) reduction, neuroprotection, memory improvement in mouse model. HPLC quantified extract, with 5,7-dimethoxyflavone (F1) being most abundant....
Coumarins, naturally occurring phytochemicals, display a wide spectrum of biological activities by acting on multiple targets. Herein, nine coumarins from the root Toddalia asiatica were evaluated for related to pathogenesis Alzheimer's disease (AD). They examined acetylcholinesterase (AChE) and AChE- or self-induced amyloid beta (Aβ) aggregation inhibitory activities, as well neuroprotection against H2O2- Aβ1-42-induced human neuroblastoma SH-SY5Y cell damage. Moreover, in order understand...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and neuronal death. Fifteen flavonoids from Millettia brandisiana were evaluated for the multifunctional effect against AD pathogenesis, including butyrylcholine esterase (BuChE) inhibition, anti-amyloid beta (Aβ) aggregation neuroprotection hydrogen peroxide (H2O2) toxicity in differentiated human neuroblastoma SH-SY5Y cell. To understand mechanism structure-activity relationship, binding...
A new flavonoid, atalantraflavone (1) as well eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4′-dihydroxy-(3″,4″-dihydro-3″,4″-dihydroxy)-2″,2″-dimethylpyrano-(5″,6″:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer's disease, acetylcholine esterase (AChE) inhibition antioxidant activity evaluated using modified...
Ten acridones isolated from Atalantia monophylla were evaluated for effects on Alzheimer’s disease pathogenesis including antioxidant effects, acetylcholinesterase (AChE) inhibition, prevention of beta-amyloid (Aβ) aggregation and neuroprotection. To understand the mechanism, type AChE inhibition was investigated in vitro binding interactions between or Aβ explored silico. Drug-likeness ADMET parameters predicted silico using SwissADME pKCSM programs, respectively. All showed favorable...
The present study aimed to investigate the effect of acridone alkaloids on cancer cell lines and elucidate underlying molecular mechanisms. ten from Atalantia monophyla were screened for cytotoxicity against LNCaP by a WST-8 assay. Then, most potential acridone, buxifoliadine E, was evaluated four types cells, namely prostate (LNCaP), neuroblastoma (SH SY5Y), hepatoblastoma (HepG2), colorectal (HT29). results showed that E able significantly inhibit proliferation all having potent HepG2...
OBJECTIVE This study aimed to identify promising ligands for inhibiting acetylcholinesterase (AChE) activity using virtual screening (VS). METHODS VS was used potential AChE inhibitors from the PubChem database. Ligands with favorable binding pocket interactions were selected. SwissADME and pkCSM tools assess drug-likeness pharmacokinetic properties. Molecular dynamic (MD) simulations provided insights into interactions. Network pharmacology explore between target molecule AD-related genes...
7‑Methoxyheptaphylline (7‑MH) is a carbazole extracted from Clausena harmandiana, medicinal plant that used to treat headaches and stomachaches. The aim of the present study was examine neuroprotective effects anticancer activity 7‑MH. Cell death assessed using an MTT assay flow cytometry. expression apoptosis‑related proteins determined by western blot analysis. An animal model test anti‑metastasis. interactions between 7‑MH molecular target were observed docking. results revealed provided...
OBJECTIVE Kaempferol-3-O-rhamnoside (compound 1) and quercetin- 3-O-rhamnoside 2), two flavonoids isolated from Mesua ferrea L. flowers, were examined for their activities related Alzheimer’s disease (AD) pathogenesis including antioxidant, acetylcholinesterase (AChE) inhibition, anti-beta amyloid (Ab) aggregation neuroprotection. METHODS The M. flowers using the column chromatography technique. Both compounds evaluated effects on AD pathogenesis, antioxidant action by ABTS assay, AChE...
A cytokine known as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has the ability to precisely cause death of cancer cells, while normal cells are left undisturbed. Recent studies show that certain sensitive apoptotic effect TRAIL. In this study, HT29 colorectal adenocarcinoma exposed TRAIL were treated with heptaphylline and 7-methoxyheptaphylline from Clausena harmandiana in an effort comprehend mechanisms involved behind activity. The...