A5007133644- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Child Nutrition and Feeding Issues
- Children's Physical and Motor Development
- Attention Deficit Hyperactivity Disorder
- Tuberous Sclerosis Complex Research
- Neurofibromatosis and Schwannoma Cases
- Metabolism and Genetic Disorders
- Genomics and Rare Diseases
- Cerebral Palsy and Movement Disorders
- Infant Development and Preterm Care
- Long-Term Effects of COVID-19
- Cerebral Venous Sinus Thrombosis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- interferon and immune responses
- Blood disorders and treatments
- Public Health and Social Inequalities
- Peripheral Neuropathies and Disorders
- Meningioma and schwannoma management
- Functional Brain Connectivity Studies
- Circadian rhythm and melatonin
Hospital Infantil Universitario Niño Jesús
2020-2025
Menéndez Pelayo International University
2024
Hospital Universitario Fundación Jiménez Díaz
2012-2019
Sociedad Española de Nefrología
2014-2017
Hospital Universitario de Getafe
2009
Abstract Objective To assess the effectiveness and tolerability of brivaracetam (BRV) in adults with epilepsy by specific comorbidities etiologies. Methods EXPERIENCE/EPD332 was a pooled analysis individual patient records from several non-interventional studies patients initiating BRV clinical practice. Outcomes included ≥ 50% reduction baseline seizure frequency, freedom (no seizures within prior 3 months), continuous since baseline), discontinuation, treatment-emergent adverse events...
haploinsufficiency results in a developmental and epileptic encephalopathy (DEE) causing generalized epilepsies accompanied by spectrum of neurodevelopmental symptoms. Concerning interictal epileptiform discharges (IEDs) electroencephalograms (EEG), potential biomarkers have been postulated, including changes background activity, fixation-off sensitivity (FOS) or eye closure (ECS). In this study we clinically evaluate new cohort 36 SYNGAP1-DEE individuals. Standardized questionnaires were...
Children with epilepsy present greater prevalence of sleep disorders than the general population. Their diagnosis is essential, since and have a bidirectional relationship. Determine incidence poor habits in children epilepsy. We conducted cross-sectional study patients under 18 years age epilepsy, assessing using Spanish-language version Sleep Disturbance Scale for (SDSC), an original questionnaire. The sample included 153 patients. Eighty-four percent our presented some type alteration....
Abstract Background Although the pathogenesis of central and obstructive events seems to be different, these two entities may somehow related. We aimed determine whether, as reported in previous research, number sleep apnea (CSA) cases a population children with syndrome (OSAS) was greater than patients without events, if CSA worsens increasing OSAS severity. As second objective, we analyzed changes index (CAI) after adenotonsillar surgery compared when no has been performed. Methods...
Insomnia is very common during childhood (30% of children under 5), and causes a serious cognitive emotional consequence in learning, as well significant medical comorbidity. It also affects the quality life, not only child, but whole family. Paediatrician training its diagnosis treatment usually poor. For this reason consensus document presented on management insomnia adolescents. This has been developed by members Spanish Paediatrics Association, Sleep Society, Society Paediatric...
This analysis assessed the effectiveness and tolerability of brivaracetam (BRV) in older (≥65 years age) younger (≥16 to <65 adults with epilepsy. was a subgroup from EXPERIENCE/EPD332, pooled individual patient records multiple independent, non-interventional studies patients epilepsy starting BRV Australia, Europe, United States. Included had ≥6 months follow-up data. Outcomes included responders (≥50 % reduction baseline seizure frequency), freedom (no seizures within 3 before time...
La marcha de puntillas idiopática (MPI) se describe como el patrón sin apoyo del talón en niños mayores 3 años. El diagnóstico es clínico y obliga a descartar otras enfermedades neurológicas traumatológicas-ortopédicas. Se postula su relación con una disfunción vestibular o sensibilidad propioceptiva. Los trastornos neurodesarrollo (trastorno espectro autista, trastorno lenguaje cognitivo) presentan frecuentemente MPI. Analizar la frecuencia MPI por déficit atención e hiperactividad (TDAH)....
Idiopathic toe-walking (ITW) is described as a gait pattern with no contact between the heels and ground in children older than 3 years. The diagnosis clinical, making it necessary to rule out other neurological orthopaedic conditions. A relationship ITW vestibular dysfunction and/or proprioceptive sensibility has been proposed. Children neurodevelopmental disorders (autism, language cognitive disorders) often have ITW. To determine frequency of attention deficit disorder hyperactivity...
Abstract In this case report, we present the of a 7-year-old male patient who started with diplopia and paralysis sixth unilateral cranial nerve after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The resonance was normal cerebrospinal pressure 32 cm H2O detected by lumbar puncture. treatment corticosteroids acetazolamide effective. This is first idiopathic intracranial hypertension associated to SARS-CoV-2 probably due immune-mediated process.
The anti-myelin oligodendrocyte glycoprotein autoantibody (anti-MOG) is recognized as a new diagnostic and prognostic markers in paediatric acquired demyelinating diseases of the central nervous system.We report 6 years gril who developed venous sinus thrombosis signs intracranial hypertension after acute otitis media.One month this infection patient had an episode unilateral optic neuritis associated with anti-MOG serum.Our received intravenous steroid treatment showed highly favourable...
Assess effectiveness and tolerability of brivaracetam in epilepsy patients with cognitive or learning disability (CLD) psychiatric comorbidities (PC) at baseline.
Purpose Patients with autism spectrum disorder (ASD) often present sleep disturbances. We evaluated the effectiveness of pediatric prolonged-release melatonin (PedPRM) in real clinical practice, focusing on a population complex neuropediatric patients highly refractory insomnia Spain. Methods The were aged 2 to 18 years, diagnosed ASD, had maintenance and/or early morning awakening insomnia, and prior therapy. starting dose PedPRM was or 5 mg (increased 10 mg, if necessary). Evaluation at 6...
Epilepsy with eyelid myoclonia (EEM) is a rare epileptic syndrome classified within the Genetic Generalized Epilepsies of childhood. It characterized by high drug resistance, and little known about prognostic factors neurodevelopmental comorbidities. The aim this study was to describe clinical features, cognitive profile, in series children EEM.This retrospective observational patients diagnosed EEM from 2012 2022 tertiary pediatric hospital.Seventeen were analyzed (mean age at symptom onset...