A5076761213- Blood Coagulation and Thrombosis Mechanisms
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Complement system in diseases
- Atrial Fibrillation Management and Outcomes
- Platelet Disorders and Treatments
- Catalytic Processes in Materials Science
- Blood groups and transfusion
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Diet and metabolism studies
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Catalysis and Oxidation Reactions
- Advanced Chemical Physics Studies
- RNA and protein synthesis mechanisms
- Hemophilia Treatment and Research
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- E-Learning and Knowledge Management
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
Massachusetts General Hospital
2017-2023
Harvard University
2008-2023
National Heart Lung and Blood Institute
2020-2022
National Institutes of Health
2020-2022
Medical University of Vienna
2021-2022
Comprehensive Cancer Center Vienna
2021
Genomics (United Kingdom)
2019
Institute for Transfusion Medicine
2019
Ludwig-Maximilians-Universität München
2016
Dana-Farber Cancer Institute
2016
Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways protein homeostasis. Blockade proteasomal degradation polyubiquitinated misfolded proteins by the proteasome inhibitor bortezomib (BTZ) achieves responses and prolongs survival in MM, but long-term treatment with BTZ leads drug-resistant relapse most patients. In a proof-of-concept study, we previously demonstrated that blocking aggresomal breakdown histone deacetylase 6 (HDAC6) tubacin enhances BTZ-induced...
We present evidence for the formation of transient hydroxyls from reaction water with atomic oxygen on Au(111) and investigate effect adsorbed hydrogen bonding water. Water is evolved in peaks at 175 195 K temperature programed experiments following adsorption oxygen-covered Au(111). The peak ascribed to sublimation multilayers water, whereas associated oxygen-stabilized or a water-hydroxyl surface complex. Infrared reflection absorption spectra are consistent presence molecular over entire...
Histone chaperones are proteins that interact with histones to regulate the thermodynamic process of nucleosome assembly. sNASP and ASF1 conserved histone H3 H4 found in a multi-chaperoning complex vivo Previously we identified short peptide motif within binds TPR domain nanomolar affinity. Interestingly, this is sequestered known ASF1-H3-H4 interface, raising question how these two together when they share same binding site. Here, show contains at least additional interaction sites that,...
BACKGROUND The introduction of therapeutic plasma exchange (TPE) dramatically decreased mortality in patients with immune thrombotic thrombocytopenic purpura (iTTP). However, there are few modern descriptions residual causes death from iTTP and complications associated TPE. STUDY DESIGN AND METHODS This was a retrospective study multi‐institutional cohort 109 between 2004 2017. Complications TPE were analyzed subset this (74 representing 101 treatment courses). RESULTS Death occurred 8...
The modification in reactivity of styrene by ozone and water was investigated on TiO2(110) as a model for heterogeneous reactions hazardous pollutants using temperature programmed desorption. Styrene desorbs from at 180, 270, 340 K, peaks tentatively assigned here to multilayer sublimation desorption Ti4+ the first layer defects (including step edges), respectively. Water compete sites when these species are coadsorbed, resulting shift 270 K peak 200 K. Styrene, however, is still able bind...
Data on lupus anticoagulant (LA) test stability in patients persistently positive for LA are limited, and its implications clinical outcomes lacking. We investigated the rate predictors of a negative whether experiencing affected patient's risk future thrombotic events or death prospective observational study LA+ patients. followed 164 (84% women) median 9.2 years total 1438 follow-up visits. During observation period, 50 (23 arterial 27 venous events) occurred, 24 died. Forty-six had at...
Patients with von Willebrand disease (VWD) often require treatment supplemental factor (VWF) prior to procedures or treat bleeding. Commercial VWF concentrates and more recently recombinant human (rVWF) have replaced cryoprecipitate as the mainstay of therapy. In comparison cryoprecipitate, content multimer distribution under current manufacturing processes these commercial products has not been reported. We measured VIII (FVIII:C), antigen (VWF:Ag), collagen-binding activity (VWF:CB),...
Extreme disease phenotypes have the potential to provide key pathophysiologic insights, but study of these conditions is challenging due their rarity and limited statistical power existing methods. Herein, we apply a novel pathway-based approach investigate role rare genomic variants in infectious purpura fulminans (PF) 1,2 , an extreme phenotype sepsis with hyperinflammation coagulopathy for which inherited risk factors currently unknown. Using whole exome sequencing, found significantly...
Mr. Q, a 72-year-old right-handed man with hypertension, hyperlipidemia, recurrent angina, and 30 pack-year smoking history is retired scientist living in the United States his wife. He recently visited native country, Ukraine, for first time almost years. After an emotional day family members, he returned home suddenly became diaphoretic weak, ultimately lost consciousness. His wife drove him to nearest open medical clinic. Because it was severely underresourced, then emergently taken by...