ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeoxygenation of highly hindered phenolsJose M. Saa, Mercedes Dopico, Gabriel Martorell, and Angel Garcia-RasoCite this: J. Org. Chem. 1990, 55, 3, 991–995Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/jo00290a033https://doi.org/10.1021/jo00290a033research-articleACS PublicationsRequest reuse permissionsArticle...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution structure of the active domain tissue inhibitor metalloproteinases-2. A new member OB fold protein familyRichard A. Williamson, Gabriel Martorell, Mark D. Carr, Gillian Murphy, Andrew J. P. Docherty, Robert B. Freedman, and James FeeneyCite this: Biochemistry 1994, 33, 39, 11745–11759Publication Date (Print):October 4, 1994Publication History Published online1 May 2002Published inissue 4 October...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPalladium-catalyzed cross-coupling reactions of highly hindered, electron-rich phenol triflates and organostannanesJose M. Saa, Gabriel Martorell, Angel Garcia-RasoCite this: J. Org. Chem. 1992, 57, 2, 678–685Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00028a051https://doi.org/10.1021/jo00028a051research-articleACS PublicationsRequest reuse...

Heterotrimeric G proteins are peripheral membrane that propagate signals from receptors to regulatory localized in distinct cellular compartments. To facilitate signal amplification, molar excess with respect protein-coupled receptors. Because capable of translocating cytosol, protein-lipid interactions play a crucial role transduction. Here, we studied the binding heterotrimeric (Galphabetagamma) model membranes (liposomes) and entities formed upon receptor-mediated activation (Galpha...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPalladium-catalyzed cross-coupling synthesis of hindered biaryls and terphenyls. Cocatalysis by copper(I) saltsJose M. Saa Gabriel MartorellCite this: J. Org. Chem. 1993, 58, 7, 1963–1966Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/jo00059a064https://doi.org/10.1021/jo00059a064research-articleACS PublicationsRequest reuse permissionsArticle...

A simple molecular sensor that uses the exclusive quenching and binding abilities of two squaramide units included within an anionic recognition site is proposed for monitoring sulfate in water.

Secondary squaramides have considerable potential as hydrogen bond donors and acceptors. In CHCl(3) both, anti- syn-squaramide rotamers are observed by NMR. The energetic barrier for anti/syn mutual interconversion determined complete band shape analysis is approximately 63 kJ mol(-1). As in proline derivatives, a low rotational crucial the design of foldable modules. this paper, folding based on driven donor atoms (N or O) located gamma position an alkyl chain secondary squaramide. We...

All globular proteins undergo transitions from their native to unfolded states if exposed either cold or heat perturbation. While the heat-induced transition is well described for a large number of proteins, in media compatible with natural environments, limited examples denatured concern artificially destabilized, instance, by presence denaturants, ad hoc point mutations, both. Here, we provide characterization low temperature state Yfh1, protein that undergoes denaturation around water...

The palladium-catalyzed carbocyclization of allyl carboxylates with alkenes developed by Oppolzer proceeds smoothly via cationic complexes (depicted schematically on the right). In contrast, two donor phosphane ligands or a bidentate ligand are not productive intermediates in cyclization process.

A novel tertiary squaramido-based reverse-turn module SQ is reported, and its conformational properties are evaluated. This easily incorporated into a α-peptide sequence by conventional solid-phase peptide synthesis. The structure characterization of the hybrid squaramido-peptide 4 described, showing that turn segment induces formation hairpin structures in water through both αSQ- βSQ-turns.

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTDirect Palladium-Catalyzed Phosphinylation of Aryl Triflates with Secondary Phosphines. Its Scope and Limitations: The Synthesis Optically Active Carboxylated 2-(Diphenylphosphino)-1,1'-binaphthalenesGabriel Martorell, Xavier Garcías, Marcus Janura, José M. SaáView Author Information Departament de Química, Universitat les Illes Balears, 07071 Palma Mallorca, Spain Cite this: J. Org. Chem. 1998, 63, 10, 3463–3467Publication Date (Web):April 30,...

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTOn the Mechanism of Lithiation Hydric Aromatics: Direct NMR Evidence for Short H−Li Contacts in Mixed Aggregates1José M. Saá, Gabriel Martorell, and Antonio FronteraView Author Information Departament de Química, Universitat les Illes Balears, 07071 Palma Mallorca, Spain Cite this: J. Org. Chem. 1996, 61, 16, 5194–5195Publication Date (Web):August 9, 1996Publication History Received27 March 1996Published online9 August inissue 1 January...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution Structure of Bound Trimethoprim in Its Complex with Lactobacillus casei Dihydrofolate ReductaseG. Martorell, M. J. Gradwell, B. Birdsall, C. Bauer, T. A. Frenkiel, H. Cheung, V. I. Polshakov, L. Kuyper, and FeeneyCite this: Biochemistry 1994, 33, 41, 12416–12426Publication Date (Print):October 18, 1994Publication History Published online1 May 2002Published inissue 18 October...

The hydrolysis of a choline carbonate through metal-free, enzyme-like mechanism has been achieved using 2-aminobenzimidazole-based deep cavitand as catalyst. supramolecular catalysis involves three steps: host–guest binding, carbamoylation and hydrolysis. Interestingly the rate-determining step proceeds programmed carbamoylcholine-cavitand intermediate that may be driven by water molecules surrounding benzimidazole walls cavity.

In vitro studies of biological macromolecules are usually performed in dilute, buffered solutions containing one or just a few different macromolecules. Under these conditions, the interactions among molecules diffusion limited. On contrary, living systems, given type surrounded by many others, at very high total concentrations. last years, there has been an increasing effort to study directly natural crowded environments, as intact bacterial cells mimicking crowding adding proteins,...

Yfh1, the yeast ortholog of frataxin, is a protein limited thermodynamic stability which undergoes cold denaturation at temperatures above water freezing point. We have previously demonstrated that its strongly dependent on ionic strength and monovalent or divalent cations are able to considerably stabilize fold. Here, we present study folded state structural determinants lead strong salt dependence. demonstrate by nuclear magnetic resonance that, room temperature, Yfh1 exists as an...

In living systems, proteins are surrounded by many other macromolecules of different nature, at high total concentrations. the last few years, there has been an increasing effort to study biological directly in natural crowded environments, such as intact bacterial cells or mimicking crowding adding proteins, polysaccharides even synthetic polymers. We have recently proposed hen egg white (HEW) a suitable, medium conditions. Here, we show that HEW can increase dramatically aggregation...