Nonalcoholic fatty liver disease and cirrhosis are strongly associated with insulin resistance glucose intolerance. To date, the influence of metformin on glycogen synthesis in is controversial. Limited studies have evaluated effect hepatic signaling pathway vivo . In this study, an insulin-resistant rat model nonalcoholic steatohepatitis was developed by high-fat high-sucrose diet feeding combination subcutaneous injection carbon tetrachloride. Liver tissues rats were featured severe...

Sphingosine kinase 1 (SphK1)/Sphingosine-1-phosphate (S1P)/S1PRs signaling pathway is known to involve the advancement of liver fibrosis. Exosomal SphK1 promotes hepatic stellate cells (HSC) migration. Salidroside (Sal) inhibits fibrosis, but its mechanism yet be elucidated. This study was explore influences Sal on SphK/S1P/S1PRs in fibrosis induced by carbon tetrachloride (CCl 4 ) vivo , and investigated affecting migration activation HSC triggered exosomal vitro . Our data showed that...

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease associated with profound metabolic changes. The purpose of this study was to identify distinctive signature from the training set 29 PBC patients, 30 hepatitis B virus (HBV)-caused cirrhosis (HBC) and 41 healthy controls, validate applicability stability model validation 21 7 (AIH) 9 HBC. sera were investigated using high resolution nuclear magnetic resonance (NMR) datasets analyzed pairwise pattern recognition methods....

Various isoforms of myocyte enhancer factor 2 (MEF2) have been shown to play a role in the activation rat hepatic stellate cells (HSCs) culture. What signals regulate MEF2 HSCs is unknown. In addition, whether MEF2s human liver (H-HSCs) not clear. Here we studied expression and function H-HSCs. Our data showed that levels MEF2A, C, D proteins are high tissues from patients with cirrhosis increase during culture-induced primary Exposure H-HSCs TGF-1 led significant MEF2A C protein enhanced...

Display advertising has been a significant source of revenue for publishers and ad networks in the online ecosystem. One main goals display is to maximize user response rate campaigns, such as click through rates (CTR) or conversion rates. Although %in industry we believe that visual appearance ads (creatives) matters propensity response, there no published work so far address this topic via systematic data-driven approach. In paper quantitatively study relationship between performance...

Studies have shown psychological distress in patients with cirrhosis, yet no studies evaluated the laboratory and physiologic correlates of symptoms cirrhosis. This study therefore measured both biochemistry data heart rate variability (HRV) analyses, aimed to identify depression, anxiety, poor sleep cirrhosis.A total 125 cirrhosis 55 healthy subjects were recruited. Each subject was assessed through routine biochemistry, 5-minutes ECG monitoring, ratings sleep. HRV analysis used evaluate...

One of the most important categories online advertising is display which provides publishers with significant revenue. Similar to other categories, main goal in maximize user response rate for campaigns, such as click through rates (CTR) or conversion rates. Previous studies have tried optimize these parameters using objectives behavioral targeting. However, there no published work so far address effect visual appearance ads (creatives) on via a systematic data-driven approach. In this...

Objective: Depression and anxiety frequently co-occur in patients with cirrhosis, but their underlying biological substrates are unclear. There is now evidence to suggest that depression accompanied by signs of an immune response. This study investigated the correlation between depression/anxiety T-lymphocyte subsets liver cirrhosis patients. Methods: A total 59 (37 males 22 females; aged 26–81 years) were enrolled study. Severity assessed through Hamilton depressive scale (HAMD, 24-item...

This paper presents an analytical method to investigate the effects of symmetric and asymmetric elastic supports on nonlinear equilibria buckling responses shallow arches. It is found that arches with can bifurcate into secondary paths high-order modes. When a small asymmetry exists in supports, arch may abruptly split lead occurrence remote unconnected equilibria. Such be obtained experimentally or numerically using typical path following controls only prior knowledge location these paths....

Aim . To investigate the mechanisms of Fuzheng Huayu (FZHY) Capsule in treatment hepatitis B (HBV)‐ associated fibrosis, HBV patients were divided into two groups, 50 cases nucleotide analogues (NAs) group, while additional NAs + FZHY group. Methods We assessed curative effects antifibrosis through liver function, FibroScan test, and biopsy detected ratio lymphocyte subsets by flow cytometry. Peripheral blood CD8 T, CD4 natural killer cell collected from cocultured with LX‐2 cells....

Aim Cirrhosis places a substantial burden on the psychological status of affected individuals. The aim our study was to identify associated factors distress in cirrhosis. Methods A total 208 patients with cirrhosis were recruited. Each patient received validated questionnaires assess gastrointestinal (GI) symptoms, depression, and anxiety. Serum brain‐derived neurotrophic factor (BDNF) levels measured by enzyme‐linked immunosorbent assay. Results 16.35% ( n = 34) diagnosed depression 10.58%...

Objective: To investigate the correlation of liver stiffness measured by FibroTouch (FT) and FibroScan (FS) with Ishak fibrosis score in patients chronic hepatitis B. Methods: A total 313 B who visited Department Liver Cirrhosis Shuguang Hospital Affiliated to Shanghai University Traditional Chinese Medicine from November 2014 May 2016 were enrolled. All underwent biopsy, FT FS used determine measurement (LSM). Serum biochemical parameters measured, aspartate aminotransferase-to-platelet...

Abstract This paper presents a network traffic anomaly detection model based on feature grouping and multiple autoencoders (multi‐AEs) integration. comprises four modules: module, learning AUC optimal threshold calculation application module. In the group features are constructed by selecting different according to their attributes variances. of normal learned multi‐AEs. each AE is calculated ROC curve verification data, thresholds for determined using Youden index. AEs that participated in...

It is an important content to generate visual place cells (VPCs) in the field of bioinspired navigation. By analyzing firing characteristic biological and existing methods for generating VPCs, a model based on environment perception similar measure abstracted this paper. VPCs’ generation process divided into three phases, including perception, measure, recruiting new cell. According process, specific method VPCs presented. External reference landmarks are obtained local invariant...

Abstract A named entity recognition (NER) model based on multiple bidirectional long short‐term memory networks (Multi‐BiLSTM) and competition mechanism (CM) is proposed. This includes three parts: word vectorization module, learning module application module. In the vectors containing semantic features are generated BERT (Bidirectional Encoder Representations from Transformers). small‐scale BiLSTM used to extract contextual of synchronously. adopted select relatively better models obtained...