A5047995280- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Biliary and Gastrointestinal Fistulas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Esophageal Cancer Research and Treatment
- Liver Diseases and Immunity
- Diverticular Disease and Complications
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal motility and disorders
- Liver Disease and Transplantation
- Acute Lymphoblastic Leukemia research
- Intestinal Malrotation and Obstruction Disorders
- Eosinophilic Esophagitis
- Hereditary Neurological Disorders
- Cancer Genomics and Diagnostics
University of Alberta
2013-2025
University of Alberta Hospital
2013-2025
Alberta Hospital Edmonton
2004-2024
Royal Alexandra Hospital
2006-2008
Montreal General Hospital
2005
St. Michael's Hospital
1999-2004
Westmead Hospital
2004
Lenox Hill Hospital
2004
University of Manitoba
2004
Wellesley Institute
2000
Background & AimsEndoscopic ultrasound–guided choledochoduodenostomy with a lumen-apposing metal stent (EUS-CDS) is promising modality for management of malignant distal biliary obstruction (MDBO) potential better patency. We compared its outcomes endoscopic retrograde cholangiopancreatography stenting (ERCP-M).MethodsIn this multicenter randomized controlled trial, we recruited patients MDBO secondary to borderline resectable, locally advanced, or unresectable peri-ampullary cancers across...
BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the preferred modality for cytological diagnosis of various cancers. Onsite cytopathology interpretation not available in most centres. OBJECTIVE: To assess whether adequacy tissue sampling assessed by an onsite cytotechnologist improves diagnostic accuracy EUS-FNA. METHODS: The present study a retrospective review all patients undergoing solid mass EUS-FNA between September 2005 and August 2007. Patients group I...
Abstract Background A retrospective chart audit (01/2022-12/2022) of endoscopic ultrasound (EUS)-guided fine needle aspiration biopsy (FNAB) solid mass lesions revealed a disappointing diagnostic yield 56% with single pass. To improve this, quality improvement (QI) intervention where endoscopists (three) were encouraged to perform three passes per patient was developed and trialed. Aims assess impact on improving the EUS-FNAB over 9-month study period. Methods completed quarterly for all...
Abstract Background A chart audit to review endoscopic ultrasound (EUS)-fine needle aspiration biopsy (FNAB) of solid mass lesions from 01/2022-12/2022 identified a diagnostic yield 75%. To improve this, quality improvement intervention including increasing the number passes 3/case, improving pass documentation in endoscopy reports, reducing individuals making cytology slides, and using formalin as transport medium for cell block preparation instead saline was developed trialed 9 months....
Abstract Background Persistent challenges in pancreaticobiliary (PB) cancer management continue to have a significant impact on patients. Prolonged access care, for diagnosis and treatment, prompted the launch of multidisciplinary approach 07/2023 provide timely patient-centred points improve overall quality life (QOL). Aims To evaluate outcomes EPIC program, with focus care timelines established collaborative pathway developed this program. Methods All consecutive patients suspected PB...
The ideal bowel cleansing regimen for colonoscopy has yet to be determined.To compare the efficacy, and patient tolerability safety of four preparation regimens.A total 834 patients undergoing outpatient were randomly assigned one regimens: 4 L polyethylene glycol (PEG); 2 PEG + 20 mg bisacodyl; 90 mL sodium phosphate (NaP); or two sachets a commercially available solution (PSMC) 300 magnesium citrate (M). primary outcome measure was which scored by blinded endoscopists using Ottawa Bowel...
Gastric antral vascular ectasia (GAVE) is characterized by red, angiomatous lesions in the antrum organized either stripes or a diffuse pattern that can be associated with upper gastrointestinal bleeding. Endoscopic band ligation (EBL) has been reported as an effective alternative therapy for patients GAVE. Consecutive diagnosis of GAVE were prospectively followed while undergoing EBL every 2 months. Hemoglobin, ferritin, and iron levels frequently recorded, clinical follow-up was performed....
Background. Preliminary studies show promise for extrahepatic islet transplantation (ITx). However, clinical comparisons with intraportal ITx outcomes remain limited. Methods. This single-center cohort study evaluates patients receiving or between 1999 and 2018. Primary outcome was stimulated C-peptide level. Secondary were fasting plasma glucose, BETA-2 scores, Multivariable logistic modeling evaluated factors independently associated a composite variable of early graft failure primary...
Peroral cholangioscopy is useful in differentiating benign from malignant biliary strictures. However, when conventional access via endoscopic retrograde cholangiopancreatography (ERCP) fails, percutaneous transhepatic (PTCS) the SpyGlass system can be used to achieve a diagnosis. Four patients with strictures whom ERCP was not possible and brushings were either nondiagnostic or unsatisfactory investigated PTCS. The technique of PTCS involves insertion cholangioscope through sheath, placed...
BACKGROUND: Endoscopic ultrasound (EUS) is accurate in diagnosing pancreatic neuroendocrine tumours (PNETs), but its impact on surgical management unclear. OBJECTIVE: To determine whether preoperative EUS findings altered the decision for, and extent of, surgery patients with PNETs. METHODS: A retrospective review of referred for because suspected PNETs was conducted. The diagnosis confirmed by EUS-guided fine needle aspiration cytology, where indicated, or histology. were compared computed...
Abstract Background & aims Endoscopic ultrasound guided-biliary drainage (EUS-BD) is a promising alternative to endoscopic retrograde cholangiopancreatography (ERCP); however, its growth has been limited by lack of multicenter randomized controlled trials (RCT) and dedicated devices. A EUS-BD lumen- apposing metal stent (LAMS) recently developed with the potential greatly facilitate technique safety procedure. We aim compare first intent approach EUS-guided choledochoduodenostomy biliary...
BACKGROUND: Single-operator cholangioscopy enables direct diagnostic visualization and therapeutic intervention in the biliary tree. There is increasing evidence of its clinical utility assessment strictures treatment difficult stones. OBJECTIVE: To describe first reported Canadian experience with managing disease using single-operator cholangioscopy. METHODS: The present study was a retrospective analysis data collected from all sequential patients undergoing for main outcome measures were...
BACKGROUND: Acetylsalicylic acid (ASA) is used in the treatment of acute myocardial infarction (AMI) but also a risk factor for peptic ulcer disease (PUD) bleeding. OBJECTIVE: To determine factors associated with continued ASA use patients AMI who develop PUD METHODS: developed bleeding during same hospitalization at two tertiary care hospitals Edmonton, Alberta, between January 1999 and December 2006, were evaluated retrospectively. Multivariate analysis was to predictors primary outcome...
Primary sclerosing cholangitis (PSC) is a chronic inflammatory condition causing bile duct strictures. Differentiating strictures from malignant transformation challenging. Cholangioscopy allows direct visualization with the option to biopsy. We describe our experience of cholangioscopy in PSC and propose novel stricture classification system based on cholangioscopic findings.All patients dominant referred for were reviewed. Based visual characteristics cholangioscopy, we extrahepatic form...
Endoscopic ultrasound (EUS) is a safe alternative to endoscopic retrograde cholangiopancreatography (ERCP) for diagnostic biliary imaging in choledocholithiasis. Evidence linking decline ERCP with the introduction of EUS clinical practice limited.To assess impact and cost implications new program on at tertiary referral centre.A retrospective review was performed data collected during first year University Alberta Hospital (Edmonton, Alberta). Patients were referred because suspicion...
While most pancreatic fluid collections (PFCs) resolve spontaneously, endoscopic ultrasound-guided transluminal drainage (EUS-TD) may be necessary. EUS-TD has evolved from multiple double-pigtail plastic stents (DPPS) to fully covered self-expanding metal (FCSEMS) and lumen-apposing (LAMS). This study compares clinical attributes of DPPS, FCSEMS LAMS.This is a single-centre retrospective review for PFCs. The primary outcome was success. Secondary outcomes were technical success, procedure...
Background and study aims Pseudocysts are the most common pancreatic cystic lesions they usually develop in association with pancreatitis of at least 4 weeks' duration. Extra-pancreatic pseudocysts, although reported, relatively uncommon. Secondary liver pseudocysts recognized within literature, patients described have required percutaneous or surgical drainage due to infection symptoms. The mechanism hepatic pseudocyst formation is not entirely clear but it postulated that this phenomenon...