A5064469044- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Antimicrobial Peptides and Activities
- Infectious Encephalopathies and Encephalitis
- Immune Response and Inflammation
- Vector-borne infectious diseases
- Bacterial biofilms and quorum sensing
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Peripheral Neuropathies and Disorders
- Porphyrin Metabolism and Disorders
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Respiratory and Cough-Related Research
The Ohio State University
2019-2023
The Ohio State University Wexner Medical Center
2022-2023
Nationwide Children's Hospital
2020
Vanderbilt University Medical Center
2017
Introduction Resurgence of pertussis, caused by Bordetella necessitates novel vaccines and vaccination strategies to combat this disease. Alum-adjuvanted acellular pertussis (aPV) delivered intramuscularly reduce bacterial numbers in the lungs immunized animals humans, but do not nasal colonization. Thus, aPV-immunized individuals are sources community transmission. We showed previously that modification a commercial aPV (Boostrix) addition Th1/17 polarizing adjuvant Colonization Factor A...
Despite high global vaccine coverage, whooping cough, also known as pertussis, caused by the gram-negative obligate human pathogen Bordetella pertussis (Bp), is resurging worldwide.The inactivated whole cell vaccines (wPV), introduced in 1940s, were extremely effective preventing severe disease, controlling bacterial burden entire respiratory tract, and transmission.Because of reactogenicity negative public perceptions regarding safety, wPV discontinued acellular subunit (1 to 5 protein...
Traditionally, whooping cough or pertussis caused by the obligate human pathogen Bordetella ( Bp ) is described as an acute disease with severe symptoms. However, many individuals who contract are either asymptomatic show very mild symptoms and yet can serve carriers sources of bacterial transmission. Biofilms important survival mechanism for bacteria in infections disease. determinants that drive biofilm formation humans ill-defined. In current study, we infection well-differentiated...
Significance Skin and soft tissue infections (SSTIs) account for a majority of visits to hospitals clinics in the United States are typically caused by Gram-positive pathogens. Recently, it was discovered that bacteria use unique pathway synthesize critical cellular cofactor heme. The divergence heme biosynthesis pathways between humans provides opportunity development new antibiotics targeting this pathway. We report here identification small-molecule activator coproporphyrinogen oxidase...
Infections and disease caused by the obligate human pathogen Bordetella pertussis (Bp) are increasing, despite widespread vaccinations. The current acellular vaccines remain ineffective against nasopharyngeal colonization, carriage, transmission. In this work, we tested hypothesis that polysaccharide (Bps), a member of poly-β-1,6-N-acetyl-D-glucosamine (PNAG/PGA) family polysaccharides promotes respiratory tract colonization Bp resisting killing antimicrobial peptides (AMPs). Genetic...
Bacteria adapt to dynamic changes in the host during chronic and recurrent infections. Bacterial microevolution is one type of adaptation that imparts a selective advantage. We hypothesize episodes disease promote through genetic mutations modulate severity. use pre-clinical model otitis media (OM) determine potential role for nontypeable Haemophilus influenzae (NTHI) sequential disease. Whole genome sequencing reveals hemoglobin binding lipooligosaccharide (LOS) biosynthesis genes,...
Bordetella bronchiseptica is an etiologic agent of respiratory diseases in animals and humans. Despite the widespread use veterinary B. vaccines, there limited information on their composition relative efficacy immune responses that they elicit. Furthermore, human vaccines are not available. We leveraged dual antigenic adjuvant functions colonization factor A (BcfA) to develop acellular absence additional adjuvant.
Abstract Infections and disease caused by the obligate human pathogen Bordetella pertussis (Bp) are increasing, despite widespread vaccinations. The current acellular vaccines remain ineffective against nasopharyngeal colonization, carriage, transmission. In this work, we tested hypothesis that polysaccharide (Bps), a member of poly-β-1,6- A -acetyl-D-glucosamine (PNAG/PGA) family polysaccharides promotes respiratory tract colonization Bp resisting killing antimicrobial peptides (AMPs)....
ABSTRACT Bordetella bronchiseptica (B. bronchiseptica) is an etiologic agent of respiratory diseases in animals and humans. Despite widespread use veterinary B. vaccines, there limited information on their composition, relative efficacy, the immune responses they elicit. Furthermore, human vaccines are not available. We leveraged dual antigenic adjuvant functions BcfA to develop acellular absence additional adjuvant. Balb/c mice immunized with alone or a trivalent vaccine containing antigens...