A5031673194- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pharmaceutical studies and practices
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Intensive Care Unit Cognitive Disorders
- Nitric Oxide and Endothelin Effects
- Asthma and respiratory diseases
- Antibiotic Use and Resistance
- Healthcare cost, quality, practices
- Immune cells in cancer
- Immune Response and Inflammation
- Dietary Effects on Health
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Gut microbiota and health
- Vagus Nerve Stimulation Research
National Cancer Institute
2024-2025
National Institutes of Health
2024-2025
Center for Cancer Research
2024
San Juan Bautista School of Medicine
2021
University of Puerto Rico at Río Piedras
2018-2019
Abstract Liver cancer ranks amongst the deadliest cancers. Nerves have emerged as an understudied regulator of tumor progression. The parasympathetic vagus nerve influences systemic immunity via acetylcholine (ACh). Whether cholinergic neuroimmune interactions influence hepatocellular carcinoma (HCC) remains uncertain. denervation hepatic vagotomy (HV) significantly reduced liver burden, while pharmacological enhancement tone promoted growth. Cholinergic disruption in Rag1KO mice revealed...
Abstract Previous studies have shown that the distribution of major immune cell populations differ across mouse strains in peripheral blood and hematopoietic organs at baseline. Additionally, variations responses exist between Leishmania spp. Melanoma models, but these context liver diseases including Non Alcoholic Fatty Liver Disease (NAFLD) Hepatocellular Carcinoma (HCC) not been carried out. With effort to state if within liver, we performed comprehensive spectral flow cytometry analysis...
Abstract Functional tumor-specific CD8+ T cells are essential for an effective anti-tumor immune response and the efficacy of checkpoint inhibitor therapy. In comparison to other organ sites, we found higher numbers in primary, metastatic liver tumors murine tumor models. Despite their abundance, displayed exhausted phenotype. Depletion showed that tumor-reactive failed control but was against subcutaneous tumors. Similarly, analysis single-cell RNA sequencing data from patients a frequency...
López-Ortiz, Bryan; Rodríguez-Matos, Francisco; Acevedo-Cajigas, Carlos; Gorbea-Fuxench, Gabriela; Hernández, Gianina; Puig-Ramos, Anabel; Puig, Gilberto Author Information
Introduction Prescription of antibiotic in pediatric patients requiring asthma medications is a highly common phenomena reported outpatient clinics as well Emergency Rooms. Inappropriate antibiotics prescription can lead to the development drug-resistant infections, which well-known public health issue. In this study we want evaluate prevalence use children admitted hospital due an exacerbation. Methods retrospective cross-sectional study, 4-21 year old Hispanic with official …
Oxidative stress and inflammatory responses play critical roles in hypoxic-ischemic brain injury. Microglial cells are rapidly activated response to injury stressful stimuli, including hypoxia. Endothelin-1 (ET-1) is a potent vasoconstrictor that has been associated with cerebrovascular diseases. Hypoxia stimulates endothelial ET-1 production. However, the role of microglia under hypoxia not clear. The aim this project was characterize effect human microglial cell line, HMC3. We induced...