A5053376093- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Hepatitis B Virus Studies
- Trauma Management and Diagnosis
- Liver physiology and pathology
- Minimally Invasive Surgical Techniques
- Vagus Nerve Stimulation Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Neuropeptides and Animal Physiology
- Dietary Effects on Health
- Diverticular Disease and Complications
- Testicular diseases and treatments
- Pleural and Pulmonary Diseases
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Hormonal Regulation and Hypertension
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Genital Health and Disease
MedStar Washington Hospital Center
2021-2025
National Cancer Institute
2023-2024
Georgetown University
2022-2024
MedStar Georgetown University Hospital
2022-2024
National Institutes of Health
2023-2024
Center for Cancer Research
2023-2024
The University of Texas Health Science Center at Houston
2019
Abu Dhabi Health Services
2015
Abstract Liver cancer ranks amongst the deadliest cancers. Nerves have emerged as an understudied regulator of tumor progression. The parasympathetic vagus nerve influences systemic immunity via acetylcholine (ACh). Whether cholinergic neuroimmune interactions influence hepatocellular carcinoma (HCC) remains uncertain. denervation hepatic vagotomy (HV) significantly reduced liver burden, while pharmacological enhancement tone promoted growth. Cholinergic disruption in Rag1KO mice revealed...
BACKGROUND: Currently, patients with a limited extent of peritoneal metastases from colon and rectal cancer are treated by cytoreductive surgery combined perioperative chemotherapy performed at experienced centers. OBJECTIVE: To statistically evaluate features that may impact survival ≥5 years. These data used in the risk/benefit analyses multidisciplinary team. DESIGN: This was retrospective review prospective database. SETTINGS: single-institution study conducted an academic center....
Pancreatic cancer is an aggressive malignancy with increasing incidence. ductal adenocarcinoma (PDAC) accounts for > 90% of pancreatic diagnoses, while other exocrine tumors are much rarer. In this review, we have focused on two rare cancers the pancreas: adenosquamous carcinoma pancreas (ASCP) and acinar cell (PACC). The latest findings regarding their cellular molecular pathology, clinical characteristics, prognosis, management discussed. New genetic transcriptomic data suggest that ASCP...
In the management of peritoneal metastases in patients with colorectal cancer, completeness cytoreduction has consistently been most prominent prognostic indicator. Other clinical and histologic features have described that may also an impact on survival.The treated by cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy were divided into two groups. One group had complete CRS second incomplete CRS. The variables these groups statistically analyzed for their survival.In 124...
Background: We conducted this study to review the patient characteristics associated with long-term survival in patients peritoneal metastases from colorectal cancer who underwent cytoreductive surgery (CRS). Methods: retrospectively investigated CRC treated curative intent or without hyperthermic intraperitoneal chemotherapy at 13 institutions worldwide between January 1985 and April 2015 survived longer than five years after first CRS for metastases. Clinical oncological features...
Introduction: Pseudocoarctation is an uncommon anomaly with different presentations that primarily discovered other abnormalities. Management required symptomatic patients. Case Report: In this paper we discuss a patient who was diagnosed incidentally and treated conservatively, followed by brief literature review discussion. Conclusion: Depending on the symptoms, surgical treatment follow-up might be indicated.
Mesothelioma is a rare, aggressive disease originating from mesothelial cells and carries poor prognosis. may arise the pleura, pericardium, or peritoneum. Peritoneal mesothelioma (PM) usually spreads in diffuse manner; however, localized unifocal form of PM occur. Literature on remains scarce.
Abstract Functional tumor-specific CD8+ T cells are essential for an effective anti-tumor immune response and the efficacy of checkpoint inhibitor therapy. In comparison to other organ sites, we found higher numbers in primary, metastatic liver tumors murine tumor models. Despite their abundance, displayed exhausted phenotype. Depletion showed that tumor-reactive failed control but was against subcutaneous tumors. Similarly, analysis single-cell RNA sequencing data from patients a frequency...
Both the prevalence and mortality of liver cancers continue to rise. Early surgical interventions, including transplantation or resection, remain only curative treatment. Nerves in periphery influence tumor growth within visceral organs. Emerging cancer neuroscience efforts linked parasympathetic vagus nerves with pathology, underscoring value vagal nerve denervation methods mouse models. Here, we describe a selective hepatic vagotomy that largely maintains non-liver innervation mice. To...
11542 Background: Gastrointestinal stromal tumor (GIST) are gastrointestinal non-epithelial neoplasms most commonly driven by somatic mutations in KIT or PDGFRA. Approximately ten percent of GIST due to germline SDHx epigenetic loss expression SDHC. While and PDGFRa respond treatment with tyrosine kinase inhibitors, effective systemic therapies for SDH-deficient have not yet been identified. indolent tumors that typically progress slowly over time. A better understanding the natural history...
Abstract Traumatic lumbar hernias are a rare subset of abdominal wall encountered following blunt trauma to the abdomen. These more commonly being found due increased use advanced imaging. Three cases traumatic were identified at our institution from 2021 2022, one which underwent delayed repair. The second case resulted in resolution and healing defect within 6 weeks presentation, third was lost follow up. Acute repair might be indicated during other intra-abdominal injuries. Delayed allows...
Traumatic diaphragmatic hernia is among the most uncommon conditions after severe trauma, and it associated with high morbidity mortality. The diagnosis difficult might be missed, but a multimodal investigation help in terms of diagnostic yield. In this case report, we present missed right rupture 14 years trauma.