A5037854636- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Appendicitis Diagnosis and Management
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Hernia repair and management
- Pancreatic and Hepatic Oncology Research
- Uterine Myomas and Treatments
- Gastric Cancer Management and Outcomes
- Testicular diseases and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Muscle and Compartmental Disorders
- Gastrointestinal Tumor Research and Treatment
- Adrenal and Paraganglionic Tumors
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Cancer, Lipids, and Metabolism
- Occupational and environmental lung diseases
- Pericarditis and Cardiac Tamponade
- Intestinal and Peritoneal Adhesions
- Cardiac tumors and thrombi
Krankenhaus Barmherzige Brüder
2021-2024
University Hospital Regensburg
2023-2024
Peritoneal metastasis is a common finding in patients with advanced gastric cancer. Beyond systemic chemotherapy, additive local treatments such as cytoreductive surgery and intraperitoneal chemotherapy are considered an inherent part of different multimodal treatment concepts for selected peritoneal metastatic This review article discusses the role (CRS) including HIPEC, NIPS, PIPAC, therapeutic options curative palliative intent.
Pseudomyxoma peritonei (PMP) is a rare peritoneal condition where mucus-secreting tumorous cells progressively produce thick, gelatin-like substance. The prognosis of patients with PMP determined by the degree cellularity within mucin (low-grade (LAMN) vs. high-grade (HAMN) histologic features) and extent disease.Prognostic relevance tumor markers CA19-9 CEA, gender, Peritoneal Cancer Index (PCI), completeness cytoreduction (CC) after cytoreductive surgery were evaluated on 193 consecutive...
Background/Aim: The aim of this study was to describe and evaluate the patterns, perioperative outcomes, survival rates patients subjected hepatic resections for ovarian-derived liver metastasis as part cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC). Furthermore, we investigated two subgroups tumor patterns: hematogenous infiltrative metastatic spread. Patients Methods: A retrospective conducted. from a University Tertiary Hepatic Peritoneal Surface...
The aim of the study was to assess diagnostic tools implemented in selecting candidates for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with special emphasis on laparoscopy.A total 229 patients underwent laparoscopy between January 2011 December 2015 peritoneal carcinomatosis were analyzed retrospectively role CRS HIPEC.After initial laparoscopy, 101 (44%) HIPEC 128 (56%) being aborted. most prevalent overall exclusion criterion extensive small bowel...
Cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) is associated with significant postoperative complications. Early detection of at-risk patients may lead to improved outcomes. The role C-reactive protein (CRP) in predicting complications has only been recently investigated.Postoperative were categorized according Clavien-Dindo classification further divided into minor (Grade <3) major ≥3A). Absolute CRP counts (mg/L) on days (POD) 1-7, proportional change was...
Resection for pancreatic malignancy remains the gold standard cure. Postoperative morbidity continues to be high even after technical innovations. This study evaluates effectiveness of a perioperative oncological surgery step-by-step protocol in reducing organ-specific complications.
Background: We conducted this study to review the patient characteristics associated with long-term survival in patients peritoneal metastases from colorectal cancer who underwent cytoreductive surgery (CRS). Methods: retrospectively investigated CRC treated curative intent or without hyperthermic intraperitoneal chemotherapy at 13 institutions worldwide between January 1985 and April 2015 survived longer than five years after first CRS for metastases. Clinical oncological features...
Background/Aim: This study compared the perioperative outcomes after same combination of hyperthermic intraperitoneal chemotherapy (HIPEC) compounds when administered for 90 min vs. 60 min, while all other therapy variables remained constant. Patients and Methods: A total 120 patients were included with peritoneal surface malignancy who underwent cisplatin (75 mg/m<sup>2</sup>) doxorubicin (15 closed HIPEC cytoreductive surgery. Results: Sixty-five (54.2%) in 55 (45.8%) group compared....
Aim: This single-centre study evaluated cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for patients rare histologies and uncommon tumour origins. Patients Methods: Prospectively collected data from the registry of a single institution was retrospectively investigated. We present series selected who underwent CRS HIPEC between 2011 2021 peritoneal metastases arising infrequent entities. Results: The included 76 patients. From wide range...
Background: The usage of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced gynecological cancers is increasing. Methods: Prospectively collected data 85 primary ovarian/fallopian tube cancer and peritoneal carcinoma patients a single center were investigated. Results: A total 48, 37, 62, 25 enrolled into the HIPEC with/without neoadjuvant (upfront vs. interval) 60 min 90 long groups, respectively. Better overall survival (OS) was observed in...
Mucinous adenocarcinoma is a frequent subtype in colorectal cancer (CRC). A higher initial T-stage, poorer differentiation, worse response to anti-tumor therapies, and shorter survival are characteristic of mucinous CRC. Moreover, the therapeutic benefit cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) CRC has not been significantly investigated.A retrospective analysis 218 patients synchronous or metachronous peritoneal metastases was conducted.129 89 had...
Background: This bicentric study evaluated cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for platinum-sensitive recurrent ovarian cancer patients. Methods: The data of 88 patients the first peritoneal recurrence epithelial who underwent CRS and HIPEC from a prospective registry were retrospectively investigated. Endpoints feasibility, chemotherapeutic compound, time exposure, complications, overall survival. Results: median follow-up was 4.7...
BACKGROUNDAdvanced gastric cancer with synchronous peritoneal metastases (GC-PM) is associated a poor prognosis.Although cytoreductive surgery hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) promising approach, only limited number of Western studies exist. AIMTo investigate the clinicopathological outcomes patients who underwent CRS-HIPEC for GC-PM. METHODSA retrospective analysis GC-PM was conducted.All were seen at Department General and Visceral Surgery, Hospital Barmherzige Brüder,...
Cancer-related immunity plays a significant role in the outcome of ovarian cancer, but exact mechanisms are not fully explored. A retrospective, real-life observational study was conducted including 57 advanced cancer patients. Immunohistochemistry for CD4+, CD8+, and CD45+ used assessing tumor-infiltrating immune cells. Furthermore, an immune-related gene expression assay performed on 12-10 samples from patients with less than more 1-year overall survival (OS), respectively. higher number...
Abstract Treatment of peritoneal surface malignancies makes physicians face demanding and new-fangled problems, as there are many uncertain aspects considering the outcomes affected patients’ prognoses. Cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC) associated with favorable long-term in carefully selected patients metastases (PM). We aim to summarize current results about initial their spreads. The literature has been scrutinized, studies between 2016 2022...
Background/Aim: Malignant struma ovarii is an extremely rare tumor entity among ovarian tumors. In the presence of ascites and peritoneal metastases, preoperative appearance may resemble most common epithelial carcinoma (EOC) accordingly, surgical therapy be identical if a histology diagnosis not possible. The objective this case report to present patient with histopathologically confirmed malignant who underwent cytoreductive surgery hyperthermic intraperitoneal chemotherapy (CRS HIPEC) aim...
To present the extraperitoneal approach for removal of peritoneal metastases in right upper abdomen patients with ovarian cancer and to evaluate safety potential advantages comparison traditional approach.Detailed description quadrant peritonectomy as approach. Procedure-specific short-term complications were retrospectively analyzed a cohort patients.Sixty-four included. Full-thickness diaphragmatic resection was performed 17% primary cases, 44% recurrent carcinoma. The rate complete...
<h3>Introduction/Background</h3> <h3>Aim</h3> To evaluate the perioperative and survival outcomes of hepatic resections for ovarian cancer derived liver metastases, as part cytoreductive surgery. <h3>Methodology</h3> A university tertiary center database was investigated retrospectively patients with primary recurrent who underwent resection surgery from January 1992 to December 2022. <h3>Results</h3> Disease-specific (DSS) overall (OS) defined time elapsed between tumour-related all-cause...
Die peritoneale Metastasierung gastrointestinaler Malignome stellt eine große therapeutische Herausforderung für Chirurgen, Onkologen sowie Strahlentherapeuten dar. Entwicklung einer multimodalen Therapie bestehend aus perioperativer systemischer Chemotherapie, radikaler zytoreduktiver Chirurgie und hyperthermer intraperitonealer Chemotherapie (HIPEC) führte zu signifikanten Verlängerung des Gesamtüberlebens dieses Patientenguts. Überlebensdaten prospektiven randomisierten Studien...
Einleitung Die chirurgische Behandlung von Patienten mit peritonealer Metastase/n (PSM) durch multiviszerale Resektion ist einer erhöhten Morbidität und Mortalität in der unmittelbaren postoperativen Phase verbunden, so dass die Intensivtherapie entscheidender Bedeutung ist. In dieser Studie wurde untersucht, ob Verlauf auf Intensivstation (ICU) Scores einen prädiktiven Wert nicht nur für das kurzfristige, sondern auch langfristige Ergebnis haben.