A5035792455- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Biomarkers in Disease Prognosis
- Pelvic floor disorders treatments
- Sexual function and dysfunction studies
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Urinary Bladder and Prostate Research
- Dermatology and Skin Diseases
- Research Data Management Practices
- Restless Legs Syndrome Research
- Syphilis Diagnosis and Treatment
- Scientific Computing and Data Management
- Cancer-related gene regulation
- Neonatal Health and Biochemistry
- Genital Health and Disease
- Sleep and related disorders
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Environmental Monitoring and Data Management
- Platelet Disorders and Treatments
- Reproductive System and Pregnancy
Ehime University
2019-2025
Saiseikai Matsuyama Hospital
2024
Evidence (Italy)
2023
Michigan Department of Education
2023
American Urological Association
2023
National Institute of Polar Research
2013
Research Organization of Information and Systems
2013
Allergic diseases and ulcerative colitis (UC) share pathophysiological similarities. This study aimed to investigate the unclear association between allergic mucosal healing (MH), an important factor in prognosis of UC. We studied 289 Japanese patients with Information on (bronchial asthma, atopic dermatitis, pollen allergy, food drug allergy), as diagnosed by physicians, was collected through self-reported questionnaires. The definition MH Mayo Endoscopic Score 0. each disease its...
A simple serum biomarker for clinical outcome in patients with ulcerative colitis (UC) remains an unmet need. Some studies have shown association between C-reactive protein (CRP)-albumin ratio (CAR) and prognosis inflammatory bowel disease (IBD), but evidence regarding the CAR UC limited. We evaluated Japanese UC.Subjects were 273 UC. Clinical remission was defined as absence of both abnormally high stool frequency (< 3 per day) rectal bleeding. Mucosal healing (MH) Mayo endoscopic subscore...
Hepatitis B vaccine induces the production of antibodies against hepatitis surface antigen (anti-HBs) and prevents virus (HBV) infection. However, 5-10% individuals cannot develop anti-HBs even after multiple vaccinations (HB non-responders). We developed an intranasal containing both HBs (HBsAg) HB core (HBcAg) mixed it with a viscosity enhancer, carboxyl vinyl polymer (CVP-NASVAC). Here, we investigated prophylactic capacity CVP-NASVAC in non-responders. Thirty-four non-responders were...
Abstract Background Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known an inflammation evaluation. However, association between platelet and MH among patients with UC still scarce. We therefore assessed this issue Japanese UC. Methods The study subjects consisted of 345 was divided into quartiles on basis distribution all (low, moderate, high, very high). Several endoscope specialists were responsible evaluating partial MH,...
Objective Serum albumin is used as a marker of acute inflammation. Several studies have addressed the association between serum and clinical outcome in patients with ulcerative colitis (UC). While mucosal healing (MH) has been indicated therapeutic goal for UC, MH remains unclear. We evaluated this issue UC overall explored whether duration affected association. Design This cross-sectional study recruited consecutive UC. Study subjects consisted 273 Japanese was divided into tertiles based...
Monocytes play an important role in innate immunity. Some epidemiological evidence indicates association between peripheral blood monocytes and ulcerative colitis (UC). The mucosal healing (MH), however, remains unclear. We evaluated this issue patients with UC. Study subjects consisted of 272 Japanese Monocyte counts were taken the morning after overnight fasting. count was divided into tertiles based on distribution values among all study subjects. Information clinical remission obtained...
Restless legs syndrome (RLS) is a common sleep disorder in the Western population. The prevalence of restless Japanese population 4.6%. Inflammatory and/or immune alteration might be associated with development syndrome. Ulcerative colitis chronic inflammatory bowel disease. Evidence regarding association between ulcerative and limited. Herein, we investigated clinical outcomes patients colitis. This was cross-sectional study using baseline data from prospective cohort study. Subjects this...
The albumin to globulin ratio (AGR) is a recognized chronic inflammation marker. No evidence regarding the relationship between AGR level and ulcerative colitis (UC) exists. aim of this study was evaluate association clinical outcomes among Japanese subjects with UC.The consisted 273 individuals UC. divided into 4 categories (low, moderate, high, very high). definition complete mucosal healing (MH) based on Mayo endoscopic subscore 0. Clinical remission (CR) defined as no rectal bleeding...
Diverse data accumulated by many science projects make up the most significant legacy of International Polar Year (IPY 2007-2008). The Data Center (PDC) National Institute Research (NIPR) has a responsibility to manage these for Japan as Antarctic (NADC) and World (WDC) Aurora. During IPY, number multidisciplinary metadata records were compiled from IPY endorsed with Japanese activity. A tight collaboration was established between Global Change Master Directory (GCMD), Information Commons...
Socioeconomic status is a risk factor for worse outcomes in many diseases. However, evidence on the association between socioeconomic and clinical outcome patients with ulcerative colitis (UC) limited. In setting, therapeutic goal UC to achieve mucosal healing (MH). Thus, aim of this study examine MH UC.The population consisted 298 UC. Education household income were divided into three groups based self-administered questionnaire. complete defined as Mayo endoscopic subscore 0-1 0,...
Objective Recently, a close association between ulcerative colitis (UC) and erectile dysfunction (ED) was reported. An inverse relationship serum albumin ED is found in patients with chronic disease. However, the levels UC unclear. This study aims to investigate this issue Japanese UC. Methods One hundred thirty‐six male were enrolled study. Information on medications for from medical records, Sexual Health Inventory Men (SHIM) score information self‐administered questionnaires severity of...
Abstract Double-stranded RNA-activated protein kinase R (PKR) is highly expressed in colorectal cancer (CRC). However, the role of PKR CRC remains unclear. The aim this study was to clarify whether C16 (a inhibitor) exhibits antitumor effects and identify its target pathway CRC. We evaluated on cell lines using MTS assay. Enrichment analysis performed C16. cycle analyzed flow cytometry. Finally, we used immunohistochemistry examine human specimens. suppressed proliferation cells. Gene...
Abstract Background Although the association between eating habits which can be modified and digestive diseases has been reported, to date, no research evaluated ulcerative colitis (UC). Thus, we investigate behavior clinical outcome in Japanese patients with UC. Methods Eating quickly, until full, skipping breakfast data was obtained from a self-administered questionnaire. Information on collected medical records. Mucosal healing (MH) partial MH defined as Mayo endoscopic subscore of 0 or...
Aim: Age is a risk factor for constipation. Constipation common in patients with ulcerative colitis (UC) and has been positively associated disease activity, but evidence limited. This study aimed to assess the association between activity constipation UC. Methods: The subjects consisted of 290 Japanese UC patients. definition was based on Rome I criteria and/or medication Information lifestyle habits obtained from self-administered questionnaire. Mucosal healing (MH) defined as Mayo...
Abstract Background Several differences in sex and clinical features among patients with ulcerative colitis (UC) have been reported. Fecal incontinence (FI) is closely associated quality of life; however, the evidence regarding FI UC limited inconsistent. Aims This study aims to examine relationship between sex, delivery history, Japanese UC. Methods A total 288 participated this study. was defined based on self-reported frequency. Information smoking status, alcohol intake status collected...
Abstract Background: No evidence regarding the association between prevalence of allergic diseases and clinical activity ulcerative colitis (UC) exists, although several studies have shown positive onset UC. Aim: This study aimed to investigate this issue in patients with Methods: We studied 289 Japanese Information (asthma, atopic dermatitis, pollen allergy, food drug allergy) diagnosed by a medical doctor, lifestyle, history were collected using self-administered questionnaire. The...
Socioeconomic status is a risk factor for poor disease prognosis. No studies of patients with ulcerative colitis (UC) have investigated the association between socioeconomic and erectile dysfunction (ED), although UC independently positively associated ED. Therefore, purpose this survey to evaluate issue in Japanese UC. The study enrolled 165 Education (low, middle, high) household income were classified three groups using self-administered surveys. information regarding Sexual Health...
Nocturia is a common symptom of lower urinary tract syndrome (LUTS). In previous studies, close association between LUTS and colorectal inflammation has been reported. However, evidence regarding the nighttime frequency ulcerative colitis (UC) limited. Herein, we investigated clinical outcomes UC.
Introduction: Recent meta-analysis showed that ulcerative colitis (UC) is a risk factor for cardiovascular disease (CVD). Dyslipidemia well-established CVD. However, evidence regarding inflammatory bowel (IBD), including UC and lipid profiles, limited. Additionally, no study has assessed the association between endoscopic activity profiles in patients with IBD. Therefore, we aimed to clarify mucosal healing (MH) UC. Methods: A total of 221 Japanese were enrolled this analysis. Total...
Abstract Background Fecal incontinence (FI) reduces patients’ quality of life. However, evidence regarding FI in patients with ulcerative colitis (UC) is limited. In previous studies UC, disease activity positively associated FI. On the other hand, association between extent and remains inconsistent. Therefore, we examined activity, extent, a combination Japanese UC. Methods This study included 290 UC patients. severe were defined on basis frequency incontinence. The was divided into total...