A5069089913- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Advanced Photocatalysis Techniques
- Cyclopropane Reaction Mechanisms
- Polyoxometalates: Synthesis and Applications
- Monoclonal and Polyclonal Antibodies Research
- Innovative Microfluidic and Catalytic Techniques Innovation
Age UK
2020-2024
GlaxoSmithKline (United Kingdom)
2019-2021
North Hertfordshire College
2021
GlaxoSmithKline (Netherlands)
2020
A practical, catalytic entry to α,α,α-trisubstituted (α-tertiary) primary amines by C-H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report simple and scalable solution this problem that does not require any situ protection of amino group proceeds with 100 % atom-economy. Our strategy, which uses an organic photocatalyst combination azide ion hydrogen atom transfer (HAT) catalyst, provides direct synthesis α-tertiary amines, or their corresponding...
Abstract Having identified inconsistencies when repeating literature examples of photochemical transformations and difficulties recreating experimental setups, we devised several criteria that an ideal lab‐scale reactor should achieve. Herein, introduce a versatile photoreactor for high‐throughput screening, preparative‐scale batch reactions continuous processing, all with single light source. The utilizes interchangeable arrays pseudo‐monochromatic high‐power LEDs in range synthetically...
Abstract Using High‐Throughput Experimentation (HTE), a visible light‐mediated etherification method was developed, employing the organic photocatalyst thioxanthen‐9‐one (TXO) and commercially available, air‐stable nickel source. Design of Experiments (DoE) techniques were utilized in conjunction with HTE to identify optimal reaction conditions which are mild, cost‐effective, robust therefore suitable for use an industrial setting. A diverse substrate scope prepared via parallel synthesis...
Abstract A practical, catalytic entry to α,α,α‐trisubstituted (α‐tertiary) primary amines by C−H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report simple and scalable solution this problem that does not require any situ protection of amino group proceeds with 100 % atom‐economy. Our strategy, which uses an organic photocatalyst combination azide ion hydrogen atom transfer (HAT) catalyst, provides direct synthesis α‐tertiary amines, or their...
We provide a new tagging entity for click chemistry to perform improved drug binding assays in intact cells.
A practical, catalytic entry to α,α,α‑trisubstituted (α‑tertiary) primary amines by C–H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report simple and scalable solution this problem that does not require any situ protection of amino group proceeds with 100% atom-economy. Our strategy, which uses an organic photocatalyst combination azide ion hydrogen atom transfer (HAT) catalyst, provides direct synthesis C -alkylated or γ‑lactams, including...
A practical, catalytic entry to α,α,α‑trisubstituted (α‑tertiary) primary amines by C–H functionalisation has long been recognised as a critical gap in the synthetic toolbox. We report simple and scalable solution this problem that does not require any <i>in situ</i> protection of amino group proceeds with 100% atom-economy. Our strategy, which uses an organic photocatalyst combination azide ion hydrogen atom transfer (HAT) catalyst, provides direct synthesis...
Click probes have enabled a thorough study of drug interactions in relevant disease models. Proper design the probes, including choice click moiety coupled to drug, is crucial ensure good performance and broad application. A new <i>trans</i>-cyclooctene derivative, amTCO, was synthesised using phthalimide protecting group as built-in photosensitiser for cyclooctene isomerization. The 1-(aminomethyl)-<i>trans</i>-cyclooct-4-ene (amTCO) displays primary amine that...