A5040535697- Renal and related cancers
- Congenital Heart Disease Studies
- Urological Disorders and Treatments
- Sexual Differentiation and Disorders
- Congenital heart defects research
Universitat de Barcelona
2022-2023
ABSTRACT Wt1 encodes a zinc finger protein that is crucial for epicardium development. Although WT1 also expressed in coronary endothelial cells (ECs), the abnormal heart development observed knockout mice mainly attributed to its functions epicardium. Here, we have generated an inducible endothelial-specific mouse model (Wt1KOΔEC). Deletion of ECs during plexus formation impaired blood vessels and myocardium RNA-Seq analysis from Wt1KOΔEC demonstrated deletion exerted major impact on...
Assessing the role of WT1 transcription factor (WT1) during early gonad differentiation and its impact on adult sex development has been difficult due to complete gonadal agenesis embryonic lethality exhibited by Wt1KO mouse models. Here, we generated Wt1LoxP/GFP;Wt1Cre mice, first model that reaches adulthood with a dramatically reduced Wt1 expression gonadogenesis. mice lacked mature gonads displayed genital tracts containing both male female structures ambiguous genitalia. We found is...