A5111249908- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Memory and Neural Mechanisms
- Pluripotent Stem Cells Research
- Zebrafish Biomedical Research Applications
- Plant Ecology and Taxonomy Studies
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Phytochemistry and Bioactive Compounds
- Child Abuse and Trauma
- Advanced MIMO Systems Optimization
- Telecommunications and Broadcasting Technologies
- Mesenchymal stem cell research
- Genetic Syndromes and Imprinting
- Advanced Differential Equations and Dynamical Systems
Yale University
2010-2024
Harbin University of Commerce
2024
Southeast University
2024
Sun Yat-sen University
2023
Bristol-Myers Squibb (United States)
2020-2022
Bristol-Myers Squibb (Germany)
2020
Children's Hospital of Chongqing Medical University
2015
Chongqing Medical University
2015
W. M. Keck Foundation
2015
Huazhong Agricultural University
2006
Deucravacitinib is an oral, selective tyrosine kinase 2 inhibitor that demonstrated therapeutic benefit in a Phase clinical trial of adults with moderate to severe plaque psoriasis. This analysis was designed evaluate the effect deucravacitinib on additional and quality-of-life (QoL) outcomes assess relationship between these Post-hoc 12-week conducted for three most efficacious dosage groups (3 mg twice daily, 6 12 once daily) placebo. Investigator assessments efficacy included Psoriasis...
The capacity to interact with conspecifics is essential for stable social networks, reproduction, and survival in mammals. In rodents, exploration play behavior increase during the juvenile period, suggesting that this timeframe represents an important window socialization. However, cellular molecular mechanisms necessary support developmental process have not been elucidated. Neurogenesis like adults, mainly confined subgranular subventricular zones. Nevertheless, levels of neurogenesis are...
Conflicting reports are available with regard to the effects of childhood abuse and neglect on hippocampal function in children. While earlier imaging studies some animal work have suggested that early-life stress (ELS) manifest only adulthood, more recent documented impaired maltreated children adolescents. Additional using modes is needed clarify ELS development. In this regard, genomic, proteomic, molecular tools uniquely mouse make it a particularly attractive model system study issue....
The composite photocatalyst FeOOH/g-C3N4 was prepared through thermal polycondensation and co-precipitation methods, followed by XRD, SEM UV-vis characterization. stability of explored the recycling test. active species in reaction system were investigated capture experiment. results indicated that optimal preparation condition for g-C3N4 involved calcination at 600 °C 4 h. XRD analysis revealed exhibits a high-purity phase, Fe exists highly dispersed amorphous state. showed has rough...
Children that are exposed to abuse or neglect show abnormal hippocampal function. However, the developmental mechanisms by which early life stress (ELS) impairs normal development have not been elucidated. Here we propose exposure ELS blunts growth inhibiting availability of ribosomal RNA (rRNA). In support this hypothesis, mouse hippocampus undergoes a growth-spurt during second week life, followed gradual decrease in DNA and content persists into adulthood. This pattern is associated with...
Abstract not available.
Given a collection $\mathcal{G} =\{G_1,G_2,\dots,G_m\}$ of graphs on the common vertex set $V$ size $n$, an $m$-edge graph $H$ same is transversal in $\mathcal{G}$ if there exists bijection $\varphi :E(H)\rightarrow [m]$ such that $e \in E(G_{\varphi(e)})$ for all $e\in E(H)$. Denote $\delta(\mathcal{G}):=\operatorname*{min}\left\{\delta(G_i): i\in [m]\right\}$. In this paper, we first establish minimum degree condition existence Hamilton paths $\mathcal{G}$: $n=m+1$ and...
Summary Crassulacean acid metabolism (CAM) photosynthesis has independently evolved many times in arid-adapted plant lineages. Cistanthe longiscapa (Montiaceae), a desert mass-blooming annual, can upregulate CAM facultatively upon stress such as drought. Few studies, however, consider life history stages when measuring activity or its facultative onset. To test the effect of drought and flowering on photosynthetic activity, we assayed individuals fully-watered conditions, well at...
Given a system $\mathcal{G} =\{G_1,G_2,\dots,G_m\}$ of graphs/digraphs/hypergraphs on the common vertex set $V$ size $n$, an $m$-edge graph/digraph/hypergraph $H$ is transversal in $\mathcal{G}$ if there exists bijection $\phi :E(H)\rightarrow [m]$ such that $e \in E(G_{\phi(e)})$ for all $e\in E(H)$. In this survey, we consider extremal problems structures graph systems. More precisely, summarize some sufficient conditions ensure existence systems, which generalize several classical...
Abstract Human trunk development, including spine and spinal cord organogenesis, is a coordinated, orderly, interdependent process with spatiotemporal tissue patterning. However, the underlying cellular molecular mechanisms remain largely unclear due to lack of an effective model that can simulate early development human body axis. Here, we reported long-term patterning dynamic morphogenesis through formation spine-spinal organoids (SSCOs) self-organized from three-dimensional culture...
Abstract not available.