A5013134052- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- RNA regulation and disease
- Cancer Cells and Metastasis
- Child Nutrition and Water Access
- Iron Metabolism and Disorders
- Gastrointestinal Tumor Research and Treatment
- Mercury impact and mitigation studies
- Hemoglobinopathies and Related Disorders
- Polysaccharides and Plant Cell Walls
- Seaweed-derived Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Pancreatic and Hepatic Oncology Research
- Cancer therapeutics and mechanisms
- Fibroblast Growth Factor Research
- PI3K/AKT/mTOR signaling in cancer
Second Affiliated Hospital of Zhejiang University
2025
Zhejiang University
2019-2021
University of South China
2021
Mudanjiang Medical University
2016
Cisplatin is regularly used in the treatment of lung cancer.However, its efficacy limited because drug resistance.In this study, we found that Akt expression and activity was increased cancer cells with acquired cisplatin resistance (A549/DDP H460/DDP cells) when compared to their parental cells.Inhibition phosphatidylinositol 3-kinase (PI3K)/Akt kinase by natural inhibitor, Wortmannin, could sensitize DDP-resistant DDP reverse resistance.Combination Wortmannin capable increasing mortality...