A5053644519- Stellar, planetary, and galactic studies
- Astronomy and Astrophysical Research
- Gamma-ray bursts and supernovae
- Astrophysics and Star Formation Studies
- Astronomical Observations and Instrumentation
- Astrophysical Phenomena and Observations
- Astro and Planetary Science
- Nuclear physics research studies
- Astronomical and nuclear sciences
- Cardiac electrophysiology and arrhythmias
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Cardiac pacing and defibrillation studies
- Chronic Myeloid Leukemia Treatments
- Cardiac Arrhythmias and Treatments
- Pulsars and Gravitational Waves Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Solar and Space Plasma Dynamics
- Calibration and Measurement Techniques
- Economic Growth and Productivity
- Adaptive optics and wavefront sensing
- Cancer Immunotherapy and Biomarkers
- Galaxies: Formation, Evolution, Phenomena
- Advanced Chemical Physics Studies
- Neutrino Physics Research
University of Florida
2020-2024
Joint Institute for Nuclear Astrophysics
2016-2024
Massachusetts Institute of Technology
2016-2021
Michigan State University
2019
Centre National de la Recherche Scientifique
2013-2018
Laboratoire Univers et Particules de Montpellier
2013-2018
Université de Montpellier
2013-2018
Bristol-Myers Squibb (Germany)
2006-2013
Bristol-Myers Squibb (United States)
2005-2013
West China Hospital of Sichuan University
2013
Brivanib is a dual inhibitor of vascular-endothelial growth factor and fibroblast receptors that are implicated in the pathogenesis hepatocellular carcinoma (HCC). Our multinational, randomized, double-blind, phase III trial compared brivanib with sorafenib as first-line treatment for HCC.Advanced HCC patients who had no prior systemic therapy were randomly assigned (ratio, 1:1) to receive 400 mg twice daily orally (n = 578) or 800 once 577). Primary end point was overall survival (OS)....
Brivanib is a selective dual inhibitor of vascular endothelial growth factor and fibroblast receptors implicated in tumorigenesis angiogenesis hepatocellular carcinoma (HCC). An unmet medical need persists for patients with HCC whose tumors do not respond to sorafenib or who cannot tolerate it. This multicenter, double-blind, randomized, placebo-controlled trial assessed brivanib had been treated sorafenib.In all, 395 advanced progressed on/after were intolerant randomly assigned (2:1)...
There is a need for new agents to treat metastatic breast cancer (MBC) in patients whom anthracycline therapy has failed or contraindicated. This study was conducted assess the efficacy and safety of novel antineoplastic, epothilone B analog ixabepilone, with MBC previously treated an adjuvant anthracycline.Patients were age >or= 18 years had received prior anthracycline-based regimen as treatment. Ixabepilone first-line chemotherapy administered 40 mg/m(2) intravenous infusion during 3...
This compilation is the fourth data release from R-Process Alliance (RPA) search for r-process-enhanced stars and second based on "snapshot" high-resolution (R ∼ 30,000) spectra collected with du Pont 2.5 m Telescope. In this release, we propose a new delineation between r-I r-II stellar classes at , instead of empirically chosen level previously in use, statistical tests complete set RPA released to date. We also statistically justify minimum [Eu/Fe] definition stars, > +0.3. Redefining...
Abstract We present a nearly complete rapid neutron-capture process ( r -process) chemical inventory of the metal-poor ([Fe/H] = −1.46 ± 0.10) -process-enhanced ([Eu/Fe] +1.32 0.08) halo star HD 222925. This abundance set is most for any object beyond solar system, with total 63 metals detected and seven upper limits. It comprises 42 elements from 31 ≤ Z 90, including rarely in stars, such as Ga, Ge, As, Se, Cd, In, Sn, Sb, Te, W, Re, Os, Ir, Pt, Au. derive these abundances an analysis 404...
To study the effect of innate cytokine macrophage migration inhibitory factor (MIF) on susceptibility and severity systemic lupus erythematosus (SLE) in a multinational population 1,369 Caucasian African American patients.Two functional polymorphisms MIF gene, -794 CATT(5-8) microsatellite repeat (rs5844572) -173 G/C single-nucleotide polymorphism (rs755622), were assessed for association with SLE 3,195 patients healthy controls. We also measured plasma levels relation to genotypes clinical...
Abstract We present a detailed abundance analysis of the bright ( V = 9.02), metal-poor ([Fe/H] −1.47 ± 0.08) field red horizontal-branch star HD 222925, which was observed as part an ongoing survey by R -Process Alliance. calculate stellar parameters and derive abundances for 46 elements based on 901 lines examined in high-resolution optical spectrum obtained using Magellan Inamori Kyocera Echelle spectrograph. detect 28 with 38 ≤ Z 90; their pattern is close match to solar r -process...
ABSTRACT We report the discovery of SMSS J160540.18−144323.1, a new ultra metal-poor halo star discovered with SkyMapper telescope. measure $\left[\rm {Fe}/\rm {H}\right]= -6.2 \pm 0.2$ (1D LTE), lowest ever detected abundance iron in star. The is strongly carbon-enhanced, {C}/\rm {Fe}\right] = 3.9 0.2$, while other abundances are compatible an α-enhanced solar-like pattern {Ca}/\rm 0.4 {Mg}/\rm 0.6 {Ti}/\rm 0.8 and no significant s- or r-process enrichment, {Sr}/\rm \lt {Ba}/\rm 1.0$ (3σ...
We present observational evidence that an aspherical supernova explosion could have occurred in the First stars early universe. Our results are based on determination of a Zn abundance Hubble Space Telescope/Cosmic Origins Spectrograph high-resolution UV spectrum hyper metal-poor (HMP) star, HE1327-2326, with [Fe/H](NLTE) = -5.2. determine [Zn/Fe] 0.80$\pm$0.25 from I line at 2138 detected $3.4\sigma$. Yields 25M$_{\odot}$ model artificially modified densities exploding E 5x10$^{51}$ ergs...
Abstract Nuclear astrophysics is a field at the intersection of nuclear physics and astrophysics, which seeks to understand engines astronomical objects origin chemical elements. This white paper summarizes progress status field, new open questions that have emerged, tremendous scientific opportunities opened up with major advances in capabilities across an ever growing number disciplines subfields need be integrated. We take holistic view discussing unique challenges regards science,...
The heaviest chemical elements are naturally produced by the rapid neutron-capture process (r-process) during neutron star mergers or supernovae. r-process production of heavier than uranium (transuranic nuclei) is poorly understood and inaccessible to experiments, so must be extrapolated using nucleosynthesis models. We examine element abundances in a sample stars that enhanced elements. Ru, Rh, Pd, Ag (atomic numbers Z = 44 47, mass A 99 110) correlate with those (63 <= 78, > 150). There...
This paper presents the detailed abundances and r-process classifications of 126 newly identified metal-poor stars as part an ongoing collaboration, R-Process Alliance. The were candidates from RAdial Velocity Experiment (RAVE) followed-up at high spectral resolution (R~31,500) with 3.5~m telescope Apache Point Observatory. atmospheric parameters determined spectroscopically Fe I lines, taking into account <3D> non-LTE corrections using differential respect to a set standards. Of new stars,...
Abstract We present a chemical abundance analysis of the faint halo metal-poor main-sequence star J0023+0307, with [Fe/H] < −6.3, based on high-resolution ( R ∼ 35,000) Magellan /MIKE spectrum. The was originally found to have −6.6 Ca ii K measurement in an 2500 No iron lines could be detected our MIKE Spectral Li, C, Na, Mg, Al, Si, and were detected. Li is close Spite Plateau, <?CDATA $\mathrm{log}\epsilon $?> (Li) = 1.7, not unlike that other stars, although stark contrast extremely...
We present a high-resolution ($R\sim35,000$), high signal-to-noise ($S/N=350$) Magellan/MIKE spectrum of the bright extremely metal-poor star 2MASS~J1808$-$5104. find [Fe/H] = $-$4.01 (spectroscopic LTE stellar parameters), $-$3.8 (photometric $-$3.7 NLTE parameters). measured carbon-to-iron ratio $\mbox{[C/Fe]}= 0.38$ from CH G-band. J1808$-$5104 is thus not carbon-enhanced, contrary to many other stars with similarly low iron abundances. also determine, for first time, barium abundance...
Orbital characteristics based on Gaia Early Data Release 3 astrometric parameters are analyzed for ${\sim} 1700$ $r$-process-enhanced (RPE; [Eu/Fe] $> +0.3$) metal-poor stars ([Fe/H] $\leq -0.8$) compiled from the $R$-Process Alliance, GALactic Archaeology with HERMES (GALAH) DR3 survey, and additional literature sources. We find dynamical clusters of these their orbital energies cylindrical actions using \HDBSCAN ~unsupervised learning algorithm. identify $36$ Chemo-Dynamically Tagged...
ABSTRACT We present a detailed chemical-abundance analysis of highly r-process-enhanced (RPE) star, 2MASS J00512646-1053170, using high-resolution spectroscopic observations with Hubble Space Telescope/STIS in the UV and Magellan/MIKE optical. determined abundances for 41 elements total, including 23 r-process rarely probed species such as Al ii, Ge i, Mo Cd Os Pt Au i. find that [Ge/Fe] = +0.10, which is an unusually high enhancement metal-poor star indicates contribution from production...
We present new ultra-metal-poor (UMP) stars parameters with [Fe/H]<-4.0 based on line-by-line non-local thermodynamic equilibrium (NLTE) abundances using an up-to-date iron model atom a recipe for non-elastic hydrogen collision rates. study the departures from LTE in their atmospheric parameter and show that they can grow up to ~1.0 dex [Fe/H], 150K Teff 0.5 log g toward lowest metallicities. Accurate NLTE stellar parameters, particular [Fe/H] being signifcantly higher, are first step...
ABSTRACT We present the first detailed chemical abundance study of ultra-faint dwarf galaxy Tucana II, based on high-resolution Magellan/MIKE spectra four red giant stars. The metallicities these stars range from [Fe/H] = −3.2 to −2.6, and all are low in neutron-capture abundances ([Sr/Fe] [Ba/Fe] < −1). However, a number anomalous signatures present. One star is relatively metal-rich ([Fe/H] −2.6) shows [Na, α , Sc/Fe] 0, suggesting an extended formation history with contributions AGB...
Abstract We present new observational benchmarks of rapid neutron-capture process ( r -process) nucleosynthesis for elements at and between the first A ∼ 80) second 130) peaks. Our analysis is based on archival ultraviolet optical spectroscopy eight metal-poor stars with Se Z = 34) or Te 52) detections, whose -process enhancement varies by more than a factor 30 (−0.22 ≤ [Eu/Fe] +1.32). calculate ratios among abundances Se, Sr through Mo (38 42), Te. These may offer empirical alternative to...