A5101659219- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
Sun Yat-sen University
2024-2025
Hypoxic tumors present a significant challenge in cancer therapy due to their ability adaptation low-oxygen environments, which supports tumor survival and resistance treatment. Enhanced mitophagy, the selective degradation of mitochondria by autophagy, is crucial mechanism that helps sustain cellular homeostasis hypoxic tumors. In this study, we develop an azocalix[4]arene-modified supramolecular albumin nanoparticle, co-delivers hydroxychloroquine mitochondria-targeting photosensitizer,...
Abstract Epidermal growth factor receptor (EGFR)‐overexpressing cutaneous squamous cell carcinoma (CSCC) necessitates more effective therapies due to its elevated metastasis risk compared the conventional CSCC. While photodynamic therapy (PDT) is a promising way treat CSCC, effectively administering photosensitizers reach deeper skin malignancies remains challenge. Herein, BE‐TEL reported, transethosome formulation designed enhance and tumor permeability, for targeted treatment of...
Despite targeted therapies like epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), non–small cell lung cancer (NSCLC) remains a clinical challenge due to drug resistance hampering their efficacy. Here, we designed an “AND” logic gate–based supramolecular therapeutic platform (HA-BPY-GEF-NPs) for the treatment of EGFR-TKI resistant NSCLC. This system integrates both internal and external stimuli–responsive mechanisms that need be activated in preset sequence, enabling it...