A5056762930- Crystallization and Solubility Studies
- Advanced Algorithms and Applications
- Industrial Technology and Control Systems
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Advanced Sensor and Control Systems
- Chemical and Physical Properties in Aqueous Solutions
- Advanced Photonic Communication Systems
- Sulfur-Based Synthesis Techniques
- Analytical Chemistry and Sensors
- Crystallography and molecular interactions
- Optical Network Technologies
- Advanced Optical Network Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Measurement and Detection Methods
- Analytical Chemistry and Chromatography
- Calcium Carbonate Crystallization and Inhibition
- Gas Sensing Nanomaterials and Sensors
- Surfactants and Colloidal Systems
- Advanced Chemical Sensor Technologies
- Semiconductor Lasers and Optical Devices
- Organoboron and organosilicon chemistry
- Grey System Theory Applications
- Semiconductor materials and interfaces
Huazhong Agricultural University
2025
Hunan University
2020-2022
State Key Laboratory of Chemobiosensing and Chemometrics
2022
Huawei Technologies (France)
2020
Tianjin University
2015-2019
State Key Laboratory of Chemical Engineering
2015-2019
Capital Medical University
2019
Huawei Technologies (China)
2004-2018
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015-2018
Changchun University
2010-2018
Crystallization is an important unit operation in the pharmaceutical industry. At present, most crystallization processes are performed batches. However, due to product variability from batch and low productivity of crystallization, continuous gaining increasing attention. In past few years, progress has been made allow products meet different requirements. This review summarizes a engineering perspective. The advantages disadvantages types compared, with main difference between two...
A general and effective palladium-catalyzed cross-coupling of organostibines with styrenes to give (E)-olefins was disclosed. By the use an organostibine reagent, this method can produce unsymmetric (E)-1,2-diarylethylenes (1E,3E)-1,4-diarylbuta-1,3-dienes in good yields high E/Z selectivity functional group tolerance. Resveratrol DMU-212 were synthesized yield. The protocol be extended synthesis (1E,3E,5E)-1,6-diphenylhexa-1,3,5-triene 40% Products 5e, 5f, 7a showed photoluminescence...
Herein, with air-stable chalcogenated stibines (Sb-ER) as organometallic chalcogenating reagents, we developed base-promoted (Z)-hydrochalcogenation of alkynes DMSO/DMSO-d6 hydrogen/deuterium sources, giving (Z)-olefins in good yields and excellent regioselectivity. These easily synthesized from halostibines situ generated [Zn(ER)2] at room temperature within a few minutes, could be also used the C(sp3)-S(Se) cross-coupling C(sp3)-X copper-catalyzed C(sp2)-S(Se) C(sp2)-X (X = F, CI, Br, I)...
Abstract A strategy for the formation of antimony‐carbon bond was developed by nickel‐catalyzed cross‐coupling halostibines. This method has been applied to synthesis various triaryl‐ and diarylalkylstibines from corresponding cyclic acyclic protocol showed a wide substrate scope (72 examples) compatible range functional groups such as aldehyde, ketone, alkene, alkyne, haloarenes (F, Cl, Br, I), heteroarenes. successful arylated stibine 3 in scale 34.77 g demonstrates high synthetic...
Continuous crystallization is a widely viewed topic as it has many advantages in industrial production. However, very resource intensive and time-consuming to determine operation conditions through trial error. Computer simulation appears an effective method continuous design. The cooling of paracetamol 5 L crystallizer was modeled investigate the effect mixing on particle size distribution (PSD). A novel coupled computational fluid dynamics–population balance equation (CFD–PBE) developed...
Cubic zeolitic imidazolate frameworks (ZIFs) nanocage was prepared by using a multitemplate and phase transfer directed method. Phase of aqueous metal ions on the interface cubic Cu2O template achieved coordinating etching precipitating process, in which morphology preserved hollow oxide nanocages were obtained due to removal templates. Therefore, ZIFs could be formed transformation cages, self-template transforming process. The former will not only template, but also source for construction...
Herein, we describe a general method for the synthesis of unsymmetric diarylmethanes from (hetero)aryl methyl halides and Sb-aryl stibines. This protocol shows broad substrate scope good functional group tolerance. Drug molecules, including beclobrate 3al bifemelane 3as, drug derivatives, celecoxib 3p, ibuprofen 3ao, probenecid 3ap, were efficiently synthesized on gram scale. The possible mechanism is proposed basis results control experiments.
Herein, we disclose a general and efficient method for the synthesis of Sb-aryl Sb-alkyl stibines by nickel-catalyzed cross-coupling halostibines with organic halides. The synthesized couple aryl halides to give biaryls efficiently via palladium catalysis. Sequential reactions polyhalogenated arenes bearing active C–I/C–Br sites inactive C–Cl successfully proceeded, resulting in formation variety complex molecules good site selectivity. Drugs such as diflunisal fenbufen, well fenofibrate...
The solubility of imatinib mesylate in nine monosolvents and two binary solvents was determined by the shaken flask method followed UV composition analysis from 278.15 to 318.15 K at atmospheric pressure. increases with increasing temperature all we chose. Meanwhile, dissolving capacity ranks as methyl acetate < 2-propanol acetonitrile isobutanol 1-butanol tetrahydrofuran 1-propanol ethanol methanol. Apelblat model, λh equation, nonrandom two-liquid (NRTL) model described data monosolvents;...
An important feature of smart grid is the intelligent power distribution function based on load forecasting with high accuracy. Accurate prediction key indicator intelligence. As a result this, this paper combines Genetic Algorithm grey model, uses to optimize initial value and background traditional GM (Grey Model), new BP neural network constructs tandem Grey Neural Network which used in grid. This model can solve problem non-isometric series, greatly improve accuracy data quality,...
Continuous crystallization has gained growing interest in the pharmaceutical industry due to its high productivity and consistency of product quality. Significant progress on control mixed-suspension mixed-product removal (MSMPR) properties with aspects crystal size distribution, polymorphism, shape been achieved. This review aims summarize different property methods put forward new viewpoints process by applying a secondary nucleation mechanism. The begins brief introduction characteristics...
A good powder performance is one of the essential targets for gabapentin (GBP). However, low bulk density and flowability GBP are still industrial problems in practical production. The main purpose this paper to investigate phase transformation from form I II methanol, ethanol, propanol, acetone, acetonitrile, ethyl acetate improve properties. results suggested that there two kinds mechanisms GBP. One classic solvent-mediated alcohols, other nonoriented self-aggregation solvents, which...
Abstract The solvate and the solvent‐free form of sulfadiazine (SD) were investigated. SD was found to exist in one N ‐methylpyrrolidone (NMP) form. NMP shown be a channel‐type compound. intrinsic properties solvents used evaluate effects solubility on phase transformation solvate. could transform by NMP‐mediated transformation, which governed crystallization crystalline solid state through solid‐solid upon heating or water penetration‐mediated transformation. rate this unusually fast. It...
New customer usages such as on-demand high-definition videos, business analytics, and cloud services stress more optical transport networks. While 100 Gbps WDM systems have been widely adopted by operators to cope with the capacity growth of past 6-7 years, a new generation transmission system is required respond exponential traffic demands coming from mobile, fixed, data center Equipment manufacturers recently planned enhance 400 rate carried channels meet this ever-increasing requirement....