A5035434121- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Catalytic Reactions
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Synthesis and Reactions
- Plant tissue culture and regeneration
- Axial and Atropisomeric Chirality Synthesis
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Insect Resistance and Genetics
- Plant Stress Responses and Tolerance
- Mycorrhizal Fungi and Plant Interactions
- Plant-Microbe Interactions and Immunity
- Chemical synthesis and alkaloids
- Oxidative Organic Chemistry Reactions
- Multicomponent Synthesis of Heterocycles
- Synthesis of Indole Derivatives
- Porphyrin and Phthalocyanine Chemistry
- Asymmetric Hydrogenation and Catalysis
- Chromosomal and Genetic Variations
- Mass Spectrometry Techniques and Applications
- Plant Parasitism and Resistance
Universidad Cardenal Herrera CEU
2023-2024
Umeå University
2023
University of Eastern Finland
2023
University of Hohenheim
2023
Aarhus University
2017-2019
Universitat Jaume I
2013-2017
University of Salerno
2015-2016
Abstract The first stereoselective organocatalyzed [3+2] cycloaddition reaction of donor‐acceptor cyclopropanes is presented. It demonstrated that by applying an optically active bifunctional Brønsted base catalyst, racemic di‐cyano cyclopropylketones can be activated to undergo a 1,3‐dipolar with mono‐ and polysubstituted nitroolefins. affords functionalized cyclopentanes three consecutive stereocenters in high yield stereoselectivity. Based on the stereochemical outcome, mechanism which...
The development of the first chemo-, regio-, and stereoselective hetero-[6+4] -[6+2] cycloadditions heteroaromatic compounds via amino aza- diazafulvenes is presented. Pyrroles, imidazoles, pyrazoles substituted with a formyl group react an aminocatalyst to generate electron-rich hetero-6π-component that reacts in manner electron-deficient dienes olefins. For cycloaddition pyrrole system dienes, wide variation both reaction partners possible, providing attractive pyrrolo-azepine products...
Nitroepoxides are easily transformed into 1,4-diamino heterocycles such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines ammonia, respectively. Additionally, related saturated heterocycles, piperazines tetrahydroquinoxalines, can be accessed 1,2-diamines a reducing agent. These transformations efficient, provide access privileged, bioactive structures, produce minimal waste.
In low nutritive environments, the uptake of N by arbuscular mycorrhizal (AM) fungi may confer competitive advantages for host. The present study aims to understand how tomato plants perceive and then prepare an depletion in root environment. Plants colonized Rhizophagus irregularis displayed improved responses a lack than nonmycorrhizal (NM) plants. These were accomplished complex metabolic transcriptional rearrangement that mostly affected gibberellic acid jasmonic pathways involving DELLA...
The first enantioselective epoxidation of readily available alkylidenemalononitriles has been developed by using a multifunctional cinchona derived thiourea as the organocatalyst and cumyl hydroperoxide oxidant. A new simple one-pot asymmetric epoxidation/SN2 ring-opening reaction with 1,2-diamines leading to important enantioenriched heterocycles, i.e. 3-substituted piperazin-2-ones, established.
Metacaspases are part of an evolutionarily broad family multifunctional cysteine proteases, involved in disease and normal development. As the structure–function relationship metacaspases remains poorly understood, we solved X-ray crystal structure Arabidopsis thaliana type II metacaspase (AtMCA-IIf) belonging to a particular subgroup not requiring calcium ions for activation. To study activity plants, developed vitro chemical screen identify small molecule inhibitors found several hits with...
We report a highly diastereoselective synthesis of vicinal diamines by the treatment nitroepoxides with primary amines and then reducing agent. When using chiral amine, racemic are transformed into as single enantiomers (>95:5 er) through dynamic kinetic asymmetric transformation (DYKAT). The overall process is one-pot procedure combining exposure to afford diastereomeric mixtures aminoimines subsequent stereoselective imine reduction.
Abstract The first stereoselective organocatalyzed [3+2] cycloaddition reaction of donor‐acceptor cyclopropanes is presented. It demonstrated that by applying an optically active bifunctional Brønsted base catalyst, racemic di‐cyano cyclopropylketones can be activated to undergo a 1,3‐dipolar with mono‐ and polysubstituted nitroolefins. affords functionalized cyclopentanes three consecutive stereocenters in high yield stereoselectivity. Based on the stereochemical outcome, mechanism which...
Nitroepoxides are potentially exploitable as synthons with vicinal electrophilic centers. Nevertheless, although advances have been made in the field, enantioselective epoxidation of nitroalkenes is still a challenging process. Herein we show convenient procedure for preparation optically active nitroepoxides high enantiomeric excess and chemical yield. The kinetic data best catalyst examined using computational methods based on DFT calculations. Interestingly, results demonstrate that...
Insecticide resistance jeopardizes the prevention of infectious diseases such as malaria and dengue fever by vector control disease-transmitting mosquitoes. Effective new insecticidal compounds with minimal adverse effects on humans environment are therefore urgently needed. Here, we explore noncovalent inhibitors well-validated target acetylcholinesterase (AChE) based a 4-thiazolidinone scaffold. The 4-thiazolidinones inhibit AChE1 from mosquitoes Anopheles gambiae Aedes aegypti at low...
Nitroepoxides are easily transformed into 2,3-disubstituted morpholines and benzoxazines in a two-step sequence by treatment with <i>N</i>-methylethanolamine <i>N</i>-methyl-2-hydroxyaniline, respectively, highly stereoselective fashion.
Abstract An enantioselective epoxidation of alkylidenemalononitriles using a cinchona‐derived thiourea as the organocatalyst and cumyl hydroperoxide oxidant is reported.
Abstract using a quaternary ammonium salt derived from cinchonine as catalyst
Abstract Metacaspases are part of an evolutionarily broad family multifunctional cysteine proteases, involved in disease and normal development. Despite the extensive study metacaspases two decades since their discovery, structure-function relationship remains poorly understood. Furthermore, previous studies on function have been thwarted by redundancy gene copy number potential phenotypic suppression genetic mutations, especially plants. Here, we solved X-ray crystal structure Arabidopsis...
Abstract Flavonoids and cannabinoids comprise two large families of natural products that contain a chromane moiety in their structure. Their therapeutic potential has been extensively investigated as treatments to several diseases, ranging from cancer infectious neurodegenerative diseases. Despite relative structural simplicity, recent years creative synthetic methodologies were designed overcome limitations the previous strategies applied these compounds. The aim this review is provide...