A5019984697- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Advanced Fluorescence Microscopy Techniques
- Biotin and Related Studies
- Erythrocyte Function and Pathophysiology
- Atrial Fibrillation Management and Outcomes
- RNA Interference and Gene Delivery
- Calibration and Measurement Techniques
- ECG Monitoring and Analysis
- Microtubule and mitosis dynamics
- Blood Pressure and Hypertension Studies
- Neuropeptides and Animal Physiology
The Hyve (Netherlands)
2024
Vrije Universiteit Amsterdam
2019
Amsterdam Neuroscience
2012-2019
Genomics (United Kingdom)
2014-2015
Amsterdam UMC Location Vrije Universiteit Amsterdam
2014
Abstract Consumer-grade wearable technology has the potential to support clinical research and patient management. Here, we report results from RATE-AF trial wearables study, which was designed compare heart rate in older, multimorbid patients with permanent atrial fibrillation failure who were randomized treatment either digoxin or beta-blockers. Heart ( n = 143,379,796) physical activity 23,704,307) intervals obtained 53 participants (mean age 75.6 years (s.d. 8.4), 40% women) using a...
MUNC18-1 (also known as STXBP1) is an essential protein for docking and fusion of secretory vesicles. Mouse chromaffin cells (MCCs) lacking show impaired vesicle docking, but also mistargeting SNARE syntaxin1 abnormally dense submembrane F-actin network. Here, we tested the contribution both these phenomena to secretion defects in MUNC18-1-deficient MCCs. We that abnormal network targeting are not observed Snap25- or Syt1-knockout (KO) MCCs, which deficient. identified a mutant (V263T...