A5045813542- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Ophthalmology and Eye Disorders
- Botulinum Toxin and Related Neurological Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Peripheral Nerve Disorders
- Cerebral Venous Sinus Thrombosis
- Pain Mechanisms and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Advanced Neuroimaging Techniques and Applications
- Medical and Biological Sciences
- Myasthenia Gravis and Thymoma
- Neurological Complications and Syndromes
- Venous Thromboembolism Diagnosis and Management
- Pharmacological Effects and Toxicity Studies
- Bone health and treatments
- Genetic Neurodegenerative Diseases
- Autoimmune Bullous Skin Diseases
- Neuroscience of respiration and sleep
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Platelet Disorders and Treatments
- Bacterial Infections and Vaccines
Monash University
2019-2025
The Alfred Hospital
2013-2025
Alfred Health
2018-2024
Austin Health
2022-2023
Monash Alfred Psychiatry Research centre
2021-2022
Australian Regenerative Medicine Institute
2021
Neurology, Inc
2021
University College London
2005-2014
National Hospital for Neurology and Neurosurgery
2010-2014
University of Tasmania
1999-2006
Summary Aims Patients with Fabry disease ( FD ) characteristically develop peripheral neuropathy at an early age, pain being a crucial symptom of underlying pathology. However, the diagnosis is challenging due to heterogeneous and nonspecific symptoms. Practical guidance on management in needed. Methods In 2014, experts met discuss recent advances this topic update clinical guidance. Results Emerging disease‐specific tools, including FabryScan, Fabry‐specific Pediatric Health Pain...
Abstract Background Calcitonin gene-related peptide (CGRP) is expressed throughout the body and a known mediator of migraine, exerting this biological effect through activation trigeminovascular, meningeal associated neuronal pathways located in close proximity to central nervous system. Monoclonal antibodies (mAb) targeting CGRP pathway are an effective new preventive treatment for with generally favourable adverse event profile. Pre-clinical evidence supports...
Schwann cell dedifferentiation following nerve injury is important to permit neural survival and axonal regrowth. Animal studies have shown that the transcription factor c-Jun upregulated in cells of injured pathological nerves where it acts as an regulator plasticity, promoting demyelination. This pilot immunohistochemical study investigates whether also human neuropathies. We examined expression normal diseased nerves, well dermal myelinated fibres. Our findings show although predicted...
Objective To determine the effectiveness and safety of erenumab in patients with chronic migraine real‐world setting 3 headache centers Australia. Methods Patients were prescribed (70 or 140 mg) either a product familiarization program paid access to medication We obtained baseline monthly prospective data on days, triptan use codeine Headache Impact Test‐6 scores, adverse reactions. In this paper, we present our at 6 months subgroup without overuse. Results A total 170 centers. At months,...
This study was undertaken to explore associations between plasma neurofilament light chain (pNfL) concentration (pg/ml) and disease activity in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) examine the usefulness of pNfL concentrations determining remission.
Background Arterial and venous thromboembolic events (TEEs) have been associated with intravenous Ig use, but the risk has poorly quantified. We aimed to calculate of TEEs exposure Ig. Methods included participants from UK Biobank recruited over 3 years, data extracted September 2020. The study endpoints were incidence myocardial infarction, other acute ischaemic heart disease, stroke, pulmonary embolism thrombosis. Predictors known TEE factors: age, sex, hypertension, smoking status, type 2...
Cognitive symptoms are reported commonly throughout all phases of a migraine; however, there is paucity objective cognitive profiling. Previous studies have been limited by practice effect, and variable populations.
Abstract Gait analysis of people with Charcot‐Marie‐Tooth (CMT) disease revealed proximal adaptive gait strategies to compensate for foot drop. We previously demonstrated that hip flexor muscle fatigue can limit walking endurance. This pilot study used a single‐blinded cross over design investigate the effect 16‐week home‐based programme resistance training on strength. Measures endurance, speed, exertion, fatigue, and general activity were also recorded. The exercise protocol was based...
Charcot-Marie-Tooth (CMT) disease type 1A is the most common form of CMT. The main clinical features are distal weakness, sensory loss, and skeletal deformities. Although pain a frequent complaint, small fiber involvement in CMT1A has not been studied extensively. We assessed 49 patients using variety scales, questionnaires, thermal thresholds. Forty-three (88%) complained pain. was localized to feet 61% patients. Only 18% had neuropathic Cold warm detection thresholds were elevated 53% 12%...
Clinical trials show that calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) are effective preventative treatments for chronic migraine. Their efficacy over longer time periods and in cohorts originally excluded from remains uncertain. This study aims to explore the impact of CGRP mAbs an Australian real-life setting.
The use of lidocaine (lignocaine) and ketamine infusion in the inpatient treatment patients with headache disorders is supported by small case series. We undertook a retrospective cohort study order to assess efficacy, duration safety infusions.Patients admitted between 01/01/2018 31/07/2021 were identified ICD code electronic prescription. Efficacy was determined reduction visual analog score (VAS), patient demographics collected from review hospital medical record.Through period, 83...
To assess the prevalence and burden of autonomic symptoms in migraine, determine relationship with migraine frequency.Autonomic have been theorized to occur setting inter-ictal sympathetic hypoactivity hyper-sensitivity. There is limited data prospectively assessing cranial extra-cranial a validated instrument, or longitudinal on between disease activity symptoms.Patients attending single tertiary academic center were recruited into prospective cohort study September 2020 June 2022. In...
Calcitonin gene-related peptide monoclonal antibodies (CGRP mAb) are an effective treatment of migraine however may have possible off-target effects. Pre-clinical studies implicate CGRP in several aspects bone turnover and homeostasis. The clinical effect mAb on is not known, however.Between June 2021 July 2022, a multi-centre prospective cohort study was undertaken with eligible patients undergoing paired testing the validated markers procollagen type I N-terminal propeptide (P1NP) serum...
Abstract Background There are no robust population-based Australian data on prevalence and attributed burden of migraine medication-overuse headache (MOH) data. In this pilot cross-sectional study, we aimed to capture the participation rate, preferred response method, acceptability self-report questionnaires inform conduct a future nationwide migraine/MOH epidemiological study. Methods We developed questionnaire, available in hard-copy online, including modules from Headache-Attributed...