A5085420959- Virus-based gene therapy research
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- Consumer Attitudes and Food Labeling
- Autopsy Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Inflammatory Myopathies and Dermatomyositis
- Reproductive Biology and Fertility
- Vitamin C and Antioxidants Research
- Phagocytosis and Immune Regulation
- Skin Diseases and Diabetes
- Dye analysis and toxicity
- RNA modifications and cancer
- Acute Myocardial Infarction Research
- melanin and skin pigmentation
- Immune cells in cancer
- Dermatological and Skeletal Disorders
- Chemotherapy-induced organ toxicity mitigation
University of Oxford
2021-2025
Technische Universität Berlin
2019-2022
Yıldız Technical University
2014-2018
University of Genoa
1988-2001
Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated tolerance. Hence, pathways that regulate macrophage phenotype are of strategic interest, with reprogramming strategies focusing on inhibitors phosphoinositide 3-kinase-gamma (PI3Kγ) due to restricted cell expression. Inhibition PI3Kγ alone is ineffective PDAC, despite increased infiltration CD8+ T cells. Objective We hypothesised...
AMA Hazini A, Cemek M, Işıldak İ, et al. Investigation of ischemia modified albumin, oxidant and antioxidant markers in acute myocardial infarction. Advances Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2015;11(4):298-303. doi:10.5114/pwki.2015.55600. APA Hazini, A., Cemek, M., Işıldak, İ., Alpdağtaş, S., Önül, & Şenel, Ü. (2015). Interwencyjnej, 11(4), 298-303. https://doi.org/10.5114/pwki.2015.55600 Chicago Ahmet, Mustafa İbrahim Saadet Abdullah Ünal Tuba Kocaman 2015....
Coxsackievirus B3 (CVB3), a single-stranded RNA virus of the picornavirus family, has been described as novel oncolytic virus. However, CVB3 strain used induced hepatitis and myocarditis in vivo. It was hypothesized that activity safety depends on its specific receptor tropism. Different laboratory strains (Nancy, 31-1-93, H3), which use coxsackievirus adenovirus (CAR), PD, uses N- 6-O-sulfated heparan sulfate (HS) for entry into cells, were investigated their potential to lyse tumor cells...
Coxsackievirus B3 (CVB3) has strong oncolytic activity in colorectal carcinoma but it also infects the pancreas and heart. To improve safety of virus, here we investigated whether cardiac toxicity can be prevented by insertion target sites (TS), which are complementary to miR-375 miR-1 into viral genome. Although abundantly expressed heart, respectively, their expression levels low carcinomas, allows carcinomas selectively attacked. investigate importance microRNAs, two viruses were...
The coxsackievirus B3 (CVB3) mouse myocarditis model is the standard for investigation of virus-induced but pancreas, rather than heart, most susceptible organ in mouse. aim this study was to develop a CVB3 which animals while attenuating viral infection pancreas and development severe pancreatitis.We developed recombinant variant H3N-375TS by inserting target sites (TS) miR-375, specifically expressed into 3'UTR genome pancreo- cardiotropic H3. In vitro evaluation showed that suppressed...
A number of chemical food coloring additives are added during processing to improve the appearance thef oods and drinks. Tartrazine carmoisine organic azo dyes widely used in products, drugs cosmetics. The present study conducted evaluate effects these via determination bioelements, oxidant antioxidant levels liver, kidney, brain tissues measurement antioxidantvitamin serum rats. Animals were administered high low doses tartrazine for a period 15 d followed by blood tissue sample collection...
A 30-year-old woman with Down's syndrome is described associating circumscribed juvenile pityriasis rubra pilaris and vitiligo. This appears to be the first reported case of in syndrome.
Coxsackievirus B3 (CVB3) has potential as a new oncolytic agent for the treatment of cancer but can induce severe pancreatitis. Here, we inserted target sequences microRNA miR‐375 (miR‐375TS) into 5′ terminus polyprotein encoding sequence or 3′UTR CVB3 strain rCVB3.1 to prevent viral replication in pancreas. In pancreatic EndoC‐βH1 cells expressing endogenously, 5′‐miR‐375TS virus and that 3′‐miR‐375TS was reduced by 4 × 10 3 ‐fold 3.9 ‐fold, respectively, compared parental rCVB3.1....
The coxsackievirus B3 strain PD-0 has been proposed as a new oncolytic virus for the treatment of colorectal carcinoma. Here, we generated cDNA clone and analyzed PD-H, newly from this cDNA, in xenografted syngenic models cancer. Replication cytotoxic assays revealed that PD-H replicated lysed carcinoma cell lines vitro well PD-0. Intratumoral injection into subcutaneous DLD-1 tumors nude mice resulted strong inhibition tumor growth significantly prolonged survival animals, but virus-induced...
Arming of oncolytic viruses with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown as a viable approach to increase the antitumor efficacy in melanoma. However, melanoma cells may be partially or completely resistant TRAIL develop resistance, thus counteracting efficiency TRAIL-armed viruses. Recently, we found that resistance can overcome by inhibition antiapoptotic Bcl-2 protein myeloid cell leukemia 1 (Mcl-1). Here, investigated whether cytotoxicity AdV-TRAIL,...
We investigated the change of IMA levels as biochemical markers, especially in postmortem diagnosis early MI. Also, histological investigation has been performed cases cardiac deaths and non-cardiac cases. To best our knowledge, this is first study to investigate A series medicolegal autopsy (n=139; 6–24 h postmortem, with a median 16 h) were examined at institute. The comprised 112 males 27 females, between 89 years age. Subjects divided into six groups depending upon their final cause...