A5061908974- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Chronic Myeloid Leukemia Treatments
- Microencapsulation and Drying Processes
- Synthesis of Indole Derivatives
- Analytical chemistry methods development
- Fluorine in Organic Chemistry
- MicroRNA in disease regulation
- Inorganic Fluorides and Related Compounds
- Meat and Animal Product Quality
- Oxidative Organic Chemistry Reactions
- Carbon dioxide utilization in catalysis
- Cancer-related molecular mechanisms research
- Synthesis and biological activity
- Nanocomposite Films for Food Packaging
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
Nanjing Forestry University
2020-2023
Shanghai Ocean University
2022
Wayne State University
2010-2014
Veterans Health Administration
2010
Colorectal cancer is the third most common form of malignancy, behind prostate and lung cancers. Despite recent advances in medicine, mortality from colorectal remains high, highlighting need for improved therapies. Numerous studies have demonstrated increased activation EGFR its family members (EGFRs), IGF-1R as well c-Src cancer. The current study was undertaken to examine effectiveness combination therapy dasatinib (BMS-354825; Bristol-Myers Squibb), a highly specific inhibitor Src...
An electrochemical sulfonylation-triggered cyclization reaction of indole-tethered terminal alkynes with sulfinates as sulfonyl sources has been developed, which affords exocyclic alkenyl tetrahydrocarbazoles in good chemical yields. This features convenient operation and tolerates a wide scope substrates variety electronically sterically diverse substituents. Furthermore, high E-stereoselectivity is observed for this reaction, provides an efficient method the preparation functionalized...
An efficient method to synthesize functionalized tetrahydrocarbazoles<italic>via</italic>radical electrochemical oxidative sulfonylation/cyclization reaction between indole derivatives and sodium sulfinates has been developed.
A series of indole-derived alkenes have been designed and applied in a photocatalytic cascade reaction with bromodifluoroacetate esters, affording an unknown type tetracyclic tetrahydro-γ-carboline derivative up to 90% yields. Mechanistic studies suggest that the proceeds as key intermediate. The tolerates diverse pool substrates, which provides efficient method for construction compounds.
A photocatalytic cascade reaction of alkene tethered indoles and bromodifluoroacetate esters has been developed, which provides a novel access to tetracyclic tetrahydrocarbazole derivatives.
In order to study the effects of compound preservatives (curcumin and piperine (CP)) vacuum packaging (VP) on quality salmon during cold chain logistics suffered from temperature abuse, physiochemical indexes (texture, water holding capacity (WHC), total volatile basic nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS), free amino acids (FAA) contents), microbial indicators (total mesophilic bacteria count (MBC), psychrotrophic (PBC), H2S-producing (HSBC)) were determined,...
A visible-light promoted cyclization reaction of 3-alkenyl indole derivatives with arylsulfonyl chlorides as coupling partners has been developed, which afforded functionalized tetrahydro-γ-carbolines in good chemical yields. The used indoles radical acceptors and proceeded via the sequence sulfonylation intramolecular cyclization. was carried out under mild conditions tolerated a wide range substrates, provides an efficient strategy for synthesis tetrahydro-γ-carboline derivatives.
Abstract A radical cascade sulfuration/cyclization of o ‐cyanoarylacrylamides with dicumyl peroxide as an oxidant and thiols coupling partners has been developed. This reaction was conducted under simple conditions showed wide substrate scope, affording the corresponding products in good chemical yields. work provides a new efficient strategy for preparation 3‐thiomethylated quinoline‐2,4‐diones.