A5087815439- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Muscle metabolism and nutrition
- Muscle activation and electromyography studies
- Intraperitoneal and Appendiceal Malignancies
- Exercise and Physiological Responses
- Hereditary Neurological Disorders
- Immunodeficiency and Autoimmune Disorders
- Neurogenetic and Muscular Disorders Research
- Nutrition and Health in Aging
- Calpain Protease Function and Regulation
- Platelet Disorders and Treatments
- Urinary and Genital Oncology Studies
- Children's Physical and Motor Development
- Genetics and Neurodevelopmental Disorders
- Extracellular vesicles in disease
- Cardiovascular Effects of Exercise
- Blood disorders and treatments
- Genetic Neurodegenerative Diseases
- Lysosomal Storage Disorders Research
- Stroke Rehabilitation and Recovery
- Diabetic Foot Ulcer Assessment and Management
Rigshospitalet
2012-2021
Herlev Hospital
2016-2021
University of Copenhagen
2013-2021
Copenhagen University Hospital
2017-2021
Gentofte Hospital
2016
Institut de Myologie
2015
Assistance Publique – Hôpitaux de Paris
2015
Sorbonne Université
2015
<h3>Objective:</h3> To investigate the effect of regular aerobic training and postexercise protein-carbohydrate supplementation in patients with facioscapulohumeral muscular dystrophy (FSHD). <h3>Methods:</h3> In this randomized, double-blind, placebo-controlled parallel study, we randomized untrained men (n = 21) women 20) FSHD (age 19–65 years) to 2 groups—training protein supplement 18) placebo 13)—and a nonintervention control group 10). We assessed fitness, walking speed, muscle...
Objective Patients with Becker muscular dystrophy (BMD) and Duchenne lack neuronal nitric oxide synthase (nNOS). nNOS mediates physiological sympatholysis, thus ensuring adequate blood supply to working muscle. In mice lacking dystrophin, restoration of effects by a phosphodiesterase 5 (PDE5) inhibitor (sildenafil) improves skeletal cardiac muscle performance. Sildenafil also flow in patients BMD. We therefore hypothesized that sildenafil would improve flow, maximal work capacity, heart...
Background Ovarian cancer is the leading cause of death by gynecologic cancers in Western world. The aim study was to identify microRNAs (miRNAs) associated with prognosis and/or resistance chemotherapy among patients epithelial ovarian cancer. Methods Using information from Pelvic Mass Study we identified a cohort women Tumor tissues were then collected and analyzed global miRNA microarrays. MiRNA profiling linked survival time progression using Cox proportional-hazards regression models....
Ovarian cancer is the fifth most common in women worldwide. Moreover, there are no reliable minimal invasive tests to secure diagnosis of malignant pelvic masses. Cell-free, circulating microRNAs have potential as diagnostic biomarkers cancer. Here, we performed and validated a miRNA panel with distinguish OC from benign masses.The profile plasma microRNA was determined 46 candidates discovery group validation group, each consisting 190 pre-surgery samples age-matched patients (n = 95) mass...
Objective The 6-minute walk test is widely used to assess functional status in neurological disorders. However, the subject great inter-test variability due fluctuating motivation, fatigue and learning effects. We investigated whether of 6MWT can be reduced by heart rate correction. Methods Sixteen patients with neuromuscular diseases, including Facioscapulohumeral muscular dystrophy, Limb-girdle Charcot-Marie-Tooths, Dystrophia Myotonica Congenital Myopathy 12 healthy subjects were studied....
Glycogen storage disease type IIIa (GSDIIIa) is classically regarded as a glycogenosis with fixed weakness, but we hypothesized that exercise intolerance in GSDIIIa related to muscle energy failure and oral fructose ingestion could improve tolerance this metabolic myopathy.We challenged metabolism cycle-ergometer measured substrate turnover oxidation rates using stable isotope methodology indirect calorimetry 3 patients 6 age-matched controls on 1 day, examined the effect of another...
Anoctamin 5 deficiency has recently been defined to cause limb-girdle muscular dystrophy type 2L (LGMD2L) with pronounced hyperCKemia. No treatment interventions have made so far in this condition.In 6 patients LGMD2L, we studied the effect of home-based, pulse-watch monitored, moderate-intensity exercise on a cycle ergometer for 30 minutes, 3 times weekly, 10 weeks. Plasma creatine kinase (CK) was assessed before, during, and after program as marker muscle damage. Primary outcome measures...
We studied the functional effects of combined strength and aerobic anti-gravity training in severely affected patients with Becker Limb-Girdle muscular dystrophies.Eight performed 10-week progressive (squats, calf raises, lunges) (walk/run, jogging place or high knee-lift) 3 times/week a lower-body positive pressure environment. Closed-kinetic-chain leg muscle strength, isometric knee rate force development (RFD), reaction time were evaluated.Baseline data indicated an intact neural...
The aim of this study was to investigate the value serum human epididymis protein 4 (HE4) and HE4 tissue expression predict tumor resistance adjuvant chemotherapy, progression-free survival (PFS), overall in patients with epithelial ovarian cancer (EOC). Consecutive inclusion 198 diagnosed EOC conducted. Blood samples were collected prior surgery during surgery. Patient data registered prospectively Danish Gynecologic Cancer Database. association between expression, PFS, analyzed univariate...
Abstract Ovarian cancer (OC) is the eighth most common type of for women worldwide. The current diagnostic and prognostic routine available OC management either lack specificity or are very costly. Gene expression profiling has shown to be a effective tool in exploring new molecular markers patients with OC, although association such patient survival clinical outcome still elusive. Here, we performed gene different subtypes evaluate its overall (OS) aggressive forms disease. By global mRNA...
Objective Ovarian cancer is the leading cause of death among gynecologic malignancies. This partly due to a non-durable response chemotherapy. Prediction resistance chemotherapy could be key role in more personalized treatment. In current study we aimed examine if microRNA based predictors predict ovarian cancer, and investigate prognostic factors for progression free overall survival. Methods Predictors chemotherapy-resistance were developed on correlation between miRNA expression...
Abstract Ovarian cancer (OC) is the second most frequent type of gynecological cancers worldwide. In past decades, development novel diagnostic and prognostic biomarkers available for OC has been limited, reflecting by lack specificity such markers or very costly management. Microarray expression profiling shown effective results in exploring new molecular patients with OC. Nonetheless, screenings are focused on mutations molecules that translated into proteins, corresponding to only 2%...
The purpose of the current study was to clarify differences in microRNA expression according clinicopathological characteristics, and investigate if miRNA profiles could predict cytoreductive outcome patients with FIGO stage IIIC IV ovarian cancer. Patients enrolled Pelvic Mass between 2004 2010, diagnosed surgically treated for epithelial cancer, were used investigation. MicroRNA profiled from tumour tissue global microarray analysis. Differences analysed histologic subtype, stage, grade,...