A5031453565- Neurobiology and Insect Physiology Research
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- RNA Research and Splicing
- Cellular transport and secretion
- Insect Resistance and Genetics
- Plant and Biological Electrophysiology Studies
- Ion channel regulation and function
- CRISPR and Genetic Engineering
- Cholinesterase and Neurodegenerative Diseases
Oregon Health & Science University
2017-2018
University of Iowa
2018
The octomeric exocyst complex governs the final step of exocytosis in both plants and animals. Its roles, however, extend beyond include organelle biogenesis, ciliogenesis, cell migration, growth. Exo70 is a conserved component whose function Drosophila unclear. In this study, we characterized two mutant alleles exo70. exo70 mutants exhibit reduced synaptic growth, locomotor activity, glutamate receptor density, mEPSP amplitude. We found that presynaptic necessary for normal growth at...
Defects in the RNA-binding protein, TDP-43, are known to cause a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. A experimental systems have shown that neurons sensitive TDP-43 expression levels, yet specific functional defects resulting from dysregulation not been well described. Using Drosophila ortholog TBPH, we previously showed TBPH-null animals display locomotion as third instar larvae. Furthermore, loss TBPH caused...
Tar DNA binding protein 43 (TDP-43) is an RNA that regulates transcription, translation, and alternative splicing of mRNA. We have shown previously null mutations the Drosophila orthologue, DNA-binding homologue (tbph), causes severe locomotion defects in larvae are mediated by a reduction expression type II voltage-gated calcium channel, cacophony (cac). also showed TDP-43 inclusion alternatively spliced exons cacophony; tbph mutants significantly increased isoforms lacking exon 7,...
Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neurodegenerative disease. The cause of disease remains obscure, and as such there no effective treatment or cure. other diseases are frequently characterized by dysfunction RNA-binding protein, TDP-43. Using model systems to understand mechanisms underlying TDP-43 should accelerate identification therapeutic targets. A recent report has shown that defects caused deletion Drosophila ortholog, tbph, not driven changes in...