A5066255359- Genetic Neurodegenerative Diseases
- Neurobiology and Insect Physiology Research
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Misinformation and Its Impacts
- Public Relations and Crisis Communication
- Amyotrophic Lateral Sclerosis Research
- Cellular transport and secretion
- Insect and Arachnid Ecology and Behavior
- Physiological and biochemical adaptations
- Media Influence and Health
- Neurogenetic and Muscular Disorders Research
- Endoplasmic Reticulum Stress and Disease
- Nuclear Structure and Function
- Neuroscience of respiration and sleep
- Healthcare and Venom Research
- RNA regulation and disease
- Zebrafish Biomedical Research Applications
- Innovative Teaching Methods
- Ubiquitin and proteasome pathways
- Humor Studies and Applications
- DNA Repair Mechanisms
- Insect Pest Control Strategies
- Expert finding and Q&A systems
Chinese University of Hong Kong
2017-2024
University of Hong Kong
2020-2022
Institute of Cytochemistry and Molecular Pharmacology
2018
University of Massachusetts Chan Medical School
2008-2012
Harvard University Press
2008
Harvard University
2007
Boston Children's Hospital
2007
Background The coronavirus disease (COVID-19) has posed an unprecedented challenge to governments worldwide. Effective government communication of COVID-19 information with the public is crucial importance. Objective We investigate how most-read state-owned newspaper in China, People’s Daily, used online social networking site, Sina Weibo, communicate about and whether this could engage public. objective study develop integrated framework examine content, message style, interactive features...
Communication is critical in a new health emergency because it motivates the public to take preventive actions. Prior research has shown that strategies including source credibility, information transparency and uncertainty reduction actions could enhance trust communication on social media. Yet how government China used these trust-building engage during outbreak of COVID-19 limited. Therefore, our exploratory study developed an integrated framework for conducting quantitative content...
Adrenergic receptors and their ligands are important regulators of synaptic plasticity metaplasticity, but the exact mechanisms underlying action still poorly understood. Octopamine, invertebrate homolog mammalian adrenaline or noradrenaline, plays roles in modulating behavior functions. We previously uncovered an octopaminergic positive-feedback mechanism to regulate structural during development response starvation. Under this mechanism, activation Octß2R autoreceptors by octopamine at...
Arthropods comprise the majority of all described animal species, and understanding their evolution is a central question in biology. Their developmental processes are under precise control distinct hormonal regulators, including sesquiterpenoids juvenile hormone (JH) methyl farnesoate. The synthesis mode action these hormones played important roles arthropods adaptation to diverse habitats. However, non-coding RNAs, such as microRNAs (miRNAs), controlling arthropod pathways unknown. Here,...
The abstract of a scientific research article convinces readers that the deserves to be read. Abstracts can also determine success publications and grant applications. In recent years, there has been trend cross-disciplinary collaborations in science community. Scientists have increasingly expected engage not only experts their own disciplines, but other disciplines with scope interest extending non-experts, such as policy-makers general public. Thus, macro-structure, metadiscoursal...
Polyglutamine (polyQ) diseases are a class of progressive neurodegenerative disorders characterized by the expression both expanded CAG RNA and misfolded polyQ protein. We previously reported that direct interaction between nucleolar protein nucleolin (NCL) impedes preribosomal ( pre-rRNA ) transcription, eventually triggers stress-induced apoptosis in diseases. Here, we report 21-amino acid peptide, named “beta-structured inhibitor for diseases” (BIND), effectively suppresses toxicity...
Abstract Polyglutamine (polyQ) diseases describe a group of progressive neurodegenerative disorders caused by the CAG triplet repeat expansion in coding region disease genes. To date, nine such diseases, including spinocerebellar ataxia type 3 ( SCA 3), have been reported. The formation SDS ‐insoluble protein aggregates neurons causes cellular dysfunctions, as impairment ubiquitin‐proteasome system, and contributes to polyQ pathologies. Recently, E3 ubiquitin ligases, which govern substrate...
Neurite outgrowth is a crucial process in developing neurons for neural network formation. Understanding the regulatory mechanisms of neurite essential strategies to stimulate regeneration after nerve injury and neurodegenerative disorders. FE65 brain-enriched adaptor that stimulates Rac1-mediated elongation. However, precise mechanism by which promotes remains elusive. Here, we show ELMO1, subunit ELMO1-DOCK180 bipartite Rac1 guanine nucleotide exchange factor (GEF), interacts with...
Bacteria with multiple drug resistance (MDR) have become a global issue worldwide, and hundreds of thousands people's lives are threatened every year. The emergence novel MDR strains insufficient development new antimicrobial agents the major reasons that limit choice antibiotics for treatment bacterial infection. Thus, preserving clinical value current could be one effective approaches to resolve this problem. Here we identified numerous small RNAs were downregulated in isolates Pseudomonas...
One drug, two diseases is a rare and economical therapeutic strategy that highly desirable in the pharmaceutical industry. We previously reported 21-amino acid peptide named beta-structured inhibitor for neurodegenerative (BIND) can effectively inhibit expanded CAG trinucleotide toxicity polyglutamine (polyQ) diseases. Here we report BIND also inhibits GGGGCC repeat-mediated neurodegeneration vitro vivo. When fused with cell-penetrating derived from transactivator of transcription (TAT)...
The octomeric exocyst complex governs the final step of exocytosis in both plants and animals. Its roles, however, extend beyond include organelle biogenesis, ciliogenesis, cell migration, growth. Exo70 is a conserved component whose function Drosophila unclear. In this study, we characterized two mutant alleles exo70. exo70 mutants exhibit reduced synaptic growth, locomotor activity, glutamate receptor density, mEPSP amplitude. We found that presynaptic necessary for normal growth at...
Amyloidogenic processing of APP by β- and γ-secretases leads to the generation amyloid-β peptide (Aβ), accumulation Aβ in senile plaques is a hallmark Alzheimer's disease (AD). Understanding mechanisms therefore paramount. Increasing evidence suggests that intracellular domain (AICD) interacting proteins influence processing. In this study, we characterized overexpression AICD interactor GULP1 Drosophila AD model expressing human BACE APP695. Transgenic significantly lowered levels both...
Abstract Myotonic dystrophy type 1 (DM1) is a multisystemic disorder that has been extensively studied for decades, yet our understanding of its neuropathological aspect remains rudimentary. In this study, we characterized novel model DM1 neuropathology by expressing untranslated expanded CUG repeats at the Drosophila larval neuromuscular junction. model, both pre- and postsynaptic expression participate to induce reduction synaptic boutons, increase arbor disassembly impairment locomotor...
<title>Abstract</title> MicroRNAs (miRNAs) are small non-coding RNAs responsible for RNA silencing and the posttranscriptional regulation of gene expression. Poly(A) polymerase D5 (PAPD5) catalyzes addition adenosine to 3′ end miRNAs, which promotes their subsequent degradation. In this study, we demonstrated that Yin Yang 1 (YY1) protein, a transcriptional repressor PAPD5, was recruited both foci protein aggregates, caused upregulation PAPD5 expression in Huntington’s disease (HD). We...
<sec> <title>BACKGROUND</title> The coronavirus disease (COVID-19) has posed an unprecedented challenge to governments worldwide. Effective government communication of COVID-19 information with the public is crucial importance. </sec> <title>OBJECTIVE</title> We investigate how most-read state-owned newspaper in China, People’s Daily, used online social networking site, Sina Weibo, communicate about and whether this could engage public. objective study develop integrated framework examine...