A5062931818- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Biochemical effects in animals
- Nicotinic Acetylcholine Receptors Study
- Receptor Mechanisms and Signaling
- Attention Deficit Hyperactivity Disorder
- Neuropeptides and Animal Physiology
- Heat transfer and supercritical fluids
- Petroleum Processing and Analysis
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Neurological Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- GABA and Rice Research
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Catalysis and Hydrodesulfurization Studies
- Catalysis and Oxidation Reactions
- Cholinesterase and Neurodegenerative Diseases
- Chemical Reactions and Isotopes
- Photoreceptor and optogenetics research
- Eicosanoids and Hypertension Pharmacology
- Thermal and Kinetic Analysis
- Advanced Power Generation Technologies
Siberian State Aerospace University
2024
Institute of Pharmacology Russian Academy of Medical Sciences
2014-2023
Russian Academy of Sciences
1979-2023
Institute of Pharmacology
2020-2022
Skolkovo Institute of Science and Technology
2020
Regional Clinical Research
2020
Moscow State Academy of Veterinary Medicine and Biotechnology named after Skryabin
2016
Federal Agency for Scientific Organizations
2016
Pharmacology Research Institute
2015
Academy of Medical Sciences
2008-2012
This article explores the use of artificial intelligence in medical field for diagnosing a disease, namely identification factors that affect presence brain tumor. Modern technologies are developing rapidly, and is becoming an increasingly important tool to help doctors accurate timely diagnosis various diseases. The focuses on application learning methods such as decision trees, Kohonen maps neural networks. development medicine provides huge potential improving diseases increasing...
Introduction: Attention deficit hyperactivity disorder (ADHD) is one of the problems modern medicine, which requires development appropriate treatments using animal models. One valid genetic models ADHD in animals spontaneous hypertensive (SH) outbred rats line. Results present paper demonstrate heterogeneity among SH line regarding measures impulsivity and attention obtained by use enriched cross-maze test assesses effects clinically effective anti-ADHD drug atomoxetine. Materials Method:...
The influence of 5-hydroxyadamantane-2-on was studied on the rats' brain blood flow and morphological state tissue under condition ischemia. interaction substance with NMDA receptors also studied.Study has been implemented using methods local registration by laser flowmeter, [(3)H]-MK-801binding, examination tissue. We used models global transient ischemia brain, occlusion middle cerebral artery, hypergravity brain.Unlike memantine, antagonist glutamatergic receptors, does not block but...
Anxiolytic drug zolpidem was incorporated into the microcontainers based on mesoporous calcium carbonate particles modified by diethylaminoethyl-dextran/hyaluronic acid shell. The release of in saline solution and polymer film modelling nasal mucosa investigated. anxiolytic effect upon intranasal administration free medicine determined vivo experiments mice.The structures all compounds during synthesis were established using nuclear magnetic resonance spectroscopy. loading efficacy kinetics...
The closed enriched cross maze test was employed as a new experimental model of the attention deficit disorder (ADD) for evaluation behavioral and neurochemical effects nootropic drug pantogam (100 mg/kg, intraperitoneally) atomoxetine hydrochloride (3 administered subchronically to CD-1 outbred mice. Two subpopulations rodents differed spontaneously in compartments (ED-Low ED-High), were estimated on basis time spent by mice empty or compartments. ED-Low ED-High insignificantly parameters...
Treatment of attention deficit hyperactivity disorder with medications is helpful in less than 60% cases suggesting the necessity development novel drugs. The most accepted animal model disease outbred spontaneously hypertensive rat strain. It was recently found a enrichment discrimination test that strain includes attentionally-low and -high phenotypes clinically efficient drug for treatment atomoxetine capable ameliorating by rats. present study aimed to generality these findings CD-1 mice...
The aim of the study was to develop better anxiolytics and antidepressants. We focused on GABA A receptors α2δ auxiliary subunit V-gated Ca2+ channels as putative targets because they are established mediators efficacious anxiolytics, antidepressants, anticonvulsants. further short peptides candidate ligands their high safety tolerability profiles. employed a structural bioinformatics approach novel tetrapeptides with predicted affinity α2δ. In silico docking studies one these peptides,...
ABSTRACT Detection of viral RNA by PCR is currently the main diagnostic tool for COVID-19 [1]. The PCR-based test, however, shows limited sensitivity, especially at early and late stages disease development [2,3], relatively time consuming. Fast reliable complementary methods detecting infection would be help in current pandemia conditions. Mass-spectrometry one such possibilities. We have developed a mass-spectrometry based method detection SARS CoV-2 virus nasopharynx epithelial swabs, on...
Background: Cycloprolylglycine (CPG) is an endogenous dipeptide with a wide range of psychotropic activity and putative therapeutic potential for depression. A small but growing body data suggests that antidepressant-like effect CPG associated neuroplastic changes in the brain or 5-HT system modulation. However, mechanisms action remain elusive. Aims: Here, we characterize effects chronic administration on behavior genes expression antidepressants sensitive catalepsy (ASC) mice strain,...