A5030897693- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Click Chemistry and Applications
- Zebrafish Biomedical Research Applications
- Synthesis and Catalytic Reactions
- Helminth infection and control
- Synthesis of heterocyclic compounds
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Nicotinic Acetylcholine Receptors Study
- Catalytic C–H Functionalization Methods
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Engineering Applied Research
- Synthesis and Biological Evaluation
- Neuroscience and Neuropharmacology Research
- Flow Measurement and Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Vehicle Noise and Vibration Control
- Insect Pest Control Strategies
N.D. Zelinsky Institute of Organic Chemistry
2017-2020
Russian Academy of Sciences
2020
A straightforward method for the synthesis of functionalized imidazo[2,1-b]thiazoles starting from benzaldehydes, 2-aminothiazoles, and alkynes under copper(I,II) catalysis was developed. The protocol allows construction a variety aryl-substituted imidazo[2,1-b]benzothiazoles, -[2,1-b]thiazoles, -[2,1-b][1,3,4]thiadiazoles. reactions were easy to perform affording most desired products in 33-93% yields. intensification process continuous-flow reactor increases products' yields up quantitative.
The three-component reaction of 2,2′-biphenyldiamines with 2-chloroacetic acid derivatives and elemental sulfur was developed for the practical synthesis unknown 2-carboxamide-substituted dibenzo[d,f][1,3]diazepines. This protocol is distinguished by efficiency in water good tolerance to functional groups can be adapted a large-scale synthesis. chemoselective preparation variety 2-S,N,O-substituted dibenzo[d,f][1,3]diazepines accomplished using method.
A facile synthesis of unsymmetrically substituted <italic>N</italic>-aryl oxalamides from 2,2′-biphenyldiamines, 2-chloroacetic acid derivatives, elemental sulfur, and water has been developed.