A5047579013- Crystallization and Solubility Studies
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- X-ray Diffraction in Crystallography
- Protein Degradation and Inhibitors
- Protein Structure and Dynamics
- Synthesis of heterocyclic compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Sulfur-Based Synthesis Techniques
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
Martin Luther University Halle-Wittenberg
2022
Sechenov University
2020
N.D. Zelinsky Institute of Organic Chemistry
2020
Russian Academy of Sciences
2020
Histone deacetylases (HDACs) are epigenetic regulators and additionally control the activity of non-histone substrates. We recently demonstrated that inhibition HDAC8 overexpressed in various cancers reduces hepatocellular carcinoma tumorigenicity a T cell-dependent manner. Here, we present alkylated hydrazide-based class I HDAC inhibitors which n-hexyl side chain attached to hydrazide moiety shows selectivity vitro. Analysis mode most promising compound 7d against revealed...
A facile synthesis of unsymmetrically substituted <italic>N</italic>-aryl oxalamides from 2,2′-biphenyldiamines, 2-chloroacetic acid derivatives, elemental sulfur, and water has been developed.
Homology modeling is a process of obtaining 3D structure protein using various algorithms based on already known structures homologous proteins. The spatial required for in silico evaluation. can be obtained different methods: NMR, Xray crystallography (XRC), and cryo-electron microscopy (cryo-EM), but these methods require lot time money. At the same time, speed nucleotide sequences analysis increasing, thereby creating mismatch between number decoded genomes investigated that are encoded...
Histone deacetylases (HDACs) are modulators of epigenetic gene regulation and additionally control the activity non-histone protein substrates by removing acyl or acetyl groups from modified lysine residues. We recently demonstrated that pharmacological inhibition HDAC8 enzyme belonging to class I HDACs overexpressed in a variety human cancers controls histone H3 27 (H3K27)-acetylation reduces hepatocellular carcinoma tumorigenicity T cell-dependent manner. Here, we present new chemotype...