A5022656619- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin C and Antioxidants Research
- Immune cells in cancer
- Regulation of Appetite and Obesity
- Vitamin K Research Studies
Universidade Federal do Rio de Janeiro
2020
Universidade Federal Fluminense
2014-2017
University of Coimbra
2017
Obesity has been associated with cognitive decline, atrophy of brain regions related to learning and memory, higher risk developing dementia. However, the molecular mechanisms underlying these neurological alterations are still largely unknown. Here, we investigate effects palmitate, a saturated fatty acid present at high amounts in fat-rich diets, brain. Palmitate is increased cerebrospinal fluid (CSF) overweight obese patients amnestic mild impairment. In mice, intracerebroventricular...
Internalization and degradation of a vitamin C transporter trigger activation microglia.
Microglial cells are the resident macrophages of central nervous system. Their function is essential for neuronal tissue homeostasis. After inflammatory stimuli, microglial become activated changing from a resting and highly ramified cell shape to an amoeboid‐like morphology. These morphological changes associated with release proinflammatory cytokines glutamate, as well high phagocytic activity. The acquisition such phenotype has been activation cytoplasmic tyrosine kinases, including those...