A5052915940- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Fatty Acid Research and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Gut microbiota and health
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Exercise and Physiological Responses
- Microbial Metabolites in Food Biotechnology
- Probiotics and Fermented Foods
- Biochemical Analysis and Sensing Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Barrier Structure and Function Studies
- Cholesterol and Lipid Metabolism
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Breastfeeding Practices and Influences
- Nuts composition and effects
- FOXO transcription factor regulation
- Cardiovascular Disease and Adiposity
Universidade Federal do Espírito Santo
2025
Universidade Estadual de Campinas (UNICAMP)
2015-2024
Universidade de São Paulo
2022
Genomic (Brazil)
2018-2020
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota production acetate. Oral administration acetate mediated interferon-β (IFN-β) response by increasing expression interferon-stimulated genes the lung. These effects were associated with reduction viral load pulmonary inflammation RSV-infected mice. Type...
Obesity has been associated with cognitive decline, atrophy of brain regions related to learning and memory, higher risk developing dementia. However, the molecular mechanisms underlying these neurological alterations are still largely unknown. Here, we investigate effects palmitate, a saturated fatty acid present at high amounts in fat-rich diets, brain. Palmitate is increased cerebrospinal fluid (CSF) overweight obese patients amnestic mild impairment. In mice, intracerebroventricular...
The chronic and low-grade inflammation induced by obesity seem to be the "first hit" retinopathy associated diabetes type 2. Herein, we hypothesized that omega-3 fatty acids from flaxseed oil enriched diet disrupt pro-inflammatory status in retina, protecting against development. For eight weeks under a high-fat (HF), several physiological parameters were monitored follow metabolic homeostasis disruption. After this period, mice treated with HF substituted part of lard (FS) for another...
Non-alcoholic fatty liver disease (NAFLD) has a positive correlation with obesity, insulin resistance and type 2 diabetes mellitus (T2D). The aerobic training is an important tool in combating NAFLD. However, no studies have demonstrated the molecular effects of short-term strength on accumulation hepatic fat obese mice. This study aimed to investigate mechanisms oxidation lipid synthesis short duration protocol was used avoid changing amount adipose tissue. Swiss mice were separated into...
The maintenance of mitochondrial activity in hypothalamic neurons is determinant to the control energy homeostasis mammals. Disturbs proteostasis can trigger mitonuclear imbalance and unfolded protein response (UPRmt) guarantee integrity function. However, role UPRmt cells are unclear. Combining transcriptomic analyses from BXD mice database vivo experiments, we demonstrated that physical training alters hypothalamus C57BL/6J mice. This elicited imbalance, increasing mtCO-1/Atp5a ratio,...
The present study evaluated the effects of exercise training on pyruvate carboxylase protein (PCB) levels in hepatic tissue and glucose homeostasis control obese mice. Swiss mice were distributed into three groups: (CTL), fed a standard rodent chow; diet-induced obesity (DIO), an obesity-inducing diet; third group, which also received diet, but was subjected to protocol (DIO + EXE). Protocol carried out for 1 h/d, 5 d/wk, 8 weeks, performed at intensity 60% exhaustion velocity. An insulin...
Obesity is closely related to insulin resistance and type 2 diabetes genesis. The liver a key organ glucose homeostasis since in this increases hepatic production (HGP) fasting hyperglycemia. protein-tyrosine phosphatase 1B (PTP1B) may dephosphorylate the IR IRS, contributing organ. Aerobic exercise great strategy increase action by reducing PTP1B content. In contrast, no study has shown direct effects of strength training on metabolism PTP1B. Therefore, aims investigate short-term (STSE)...
Obesity is linked to a reduction in the control of hepatic glucose production, which primary mechanism related fasting hyperglycemia and development type 2 diabetes mellitus (T2DM). The main system involved gluconeogenesis synthesis controlled by pyruvate carboxylase (PC), increases obesity conditions. Recently, we showed that short-term strength training an important tool against obesity-induced hyperglycemia. As aerobic exercise can reduce PC content obese animals, hypothesized also...
Abstract Background The brown adipose tissue (BAT) is a potential target for the treatment of obesity and metabolic disorders. Its activation by cold exposure or adrenergic drugs can increase systemic insulin sensitivity improve lipid metabolism; however, little known about effects specific dietary components on BAT activity. Objectives We asked if short-term (4 weeks) intervention with olive oil could modify activity in lean overweight/obese volunteers. Design This was 4-week open clinical...
Abstract Adiponectin is an adipokine that acts in the control of energy homeostasis. The adaptor protein containing pleckstrin homology domain, phosphotyrosine‐binding and leucine zipper motif 1 ( APPL 1) a key adiponectin signaling. mediates positive effect on insulin signaling through interaction with phosphoinositide 3‐kinase PI 3K). Thus, present study aimed to explore effects acute physical exercise session hypothalamic Firstly, using bioinformatics analysis, we found negative...
Abstract Obesity is a worldwide health problem and directly associated with insulin resistance type 2 diabetes. The liver an important organ for the control of healthy glycemic levels, since in this reduces phosphorylation forkhead box protein 1 (FOXO1) protein, leading to higher hepatic glucose production (HGP) fasting hyperglycemia. Aerobic physical training known as strategy increasing action by FOXO1 reducing gluconeogenesis. However, little about effects strength context. This study...
Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding action in the lung parenchyma context of obesity. The objective to investigate effects flaxseed oil (FS), rich α-linolenic (C18:3 - ω3), on lungs obese mice. Mice were fed a high-fat diet (HF) 8 weeks induce Subsequently, part these animals received HF containing FS another weeks. consumption induced weight gain and hyperglycemia. shows complete profile,...
PURPOSE: CLK2 protein (Cdc2-like kinase) after being phosphorylated by Akt, phosphorylates PGC-1a and consequently reduces the transcription of gluconeogenic genes. Obese insulin resistant (IR) animals showed lower levels in liver, which makes this an important therapeutic target control glucose homeostasis. On other hand, exercise is effective strategy to reduce IR hepatic production. So far, no study has been performed order assess role modulating obese animals. Therefore, aim was evaluate...
The western diet and sedentary lifestyle are among the biggest contributors to obesity development.Studies have shown that adipose tissue dysfunction may be one of major determinants metabolic deficiencies in obese individuals, especially visceral tissue, such as mesentery.Therefore, present study aim evaluate high fat (HFD) with substitution 10% flaxseed (FS) influence after 3 days consumption.Animals C57BL/6J, 4 weeks old, were used.After treatment, it was observed HFD animals presented...