A5069813466- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Muscle metabolism and nutrition
- Endoplasmic Reticulum Stress and Disease
- FOXO transcription factor regulation
- Metabolism, Diabetes, and Cancer
- Cardiovascular and exercise physiology
- Dietary Effects on Health
- Genetics, Aging, and Longevity in Model Organisms
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Biochemical effects in animals
- Sirtuins and Resveratrol in Medicine
- Extracellular vesicles in disease
- Fatty Acid Research and Health
- Protein Tyrosine Phosphatases
- Dental materials and restorations
- Health and Well-being Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone Tissue Engineering Materials
- Circular RNAs in diseases
- Antioxidant Activity and Oxidative Stress
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
Universidade Estadual Paulista (Unesp)
2014-2018
Universidade de São Paulo
2017-2018
Universidade Estadual de Campinas (UNICAMP)
2011-2016
Universidade Federal de São Paulo
2011
Subclinical systemic inflammation is a hallmark of obesity and insulin resistance. The results obtained from number experimental studies suggest that targeting different components the inflammatory machinery may result in improvement metabolic phenotype. Unsaturated fatty acids exert antiinflammatory activity through several distinct mechanisms. Here, we tested capacity ω3 ω9 acids, directly their food matrix, to G protein-coupled receptor (GPR)120 GPR40 pathways. GPR120 was activated liver,...
Hepatic insulin resistance is the major contributor to fasting hyperglycemia in type 2 diabetes. The protein kinase Akt plays a central role suppression of gluconeogenesis involving forkhead box O1 (Foxo1) and peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α), control glycogen synthesis synthase beta (GSK3β) liver. It has been demonstrated that endosomal adaptor APPL1 interacts with blocks association its endogenous inhibitor, tribbles-related 3 (TRB3), improving...
It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In present study, we investigated whether improvement sensitivity and signaling, mediated by acute exercise, could be modulation of protein-tyrosine phosphatase 1B (PTP-1B) liver old rats. Aging rats were subjected to swimming for two 1.5-h long bouts, separated a 45 min rest period. Sixteen hours after sacrificed proteins from signaling pathway analyzed...
To maintain euglycemia in healthy organisms, hepatic glucose production is increased during fasting and decreased the postprandial period. This whole process supported by insulin levels. These responses are associated with signaling pathway reduction activity of key gluconeogenic enzymes, resulting a decrease production. On other hand, defects liver might promote inadequate suppression gluconeogenesis, leading to hyperglycemia after meals. The hepatocyte nuclear factor 4, transcription...
This study aims to evaluate the effects of acute exercise on tribbles homolog 3 (TRB3) protein levels and interaction between TRB3 Akt proteins in hypothalamus obese rats. In addition, we evaluated relationship endoplasmic reticulum (ER) stress verified whether an session influences them.In first part study, rats were divided into three groups: control (lean), fed standard rodent chow; DIO, a high-fat diet; DIO-EXE, diet submitted swimming protocol. second used other (lean) group receiving...
Insulin plays an important role in the control of hepatic glucose production. resistant states are commonly associated with excessive production, which contributes to both fasting hyperglycaemia and exaggerated postprandial hyperglycaemia. In this regard, increased activity phosphatases may contribute dysregulation gluconeogenesis. Mitogen-activated protein kinase phosphatase-3 (MKP-3) is a key involved MKP-3-mediated dephosphorylation activates FoxO1 (a member forkhead family transcription...
This study investigated the effects of exercise training in regulating inflammatory processes, endoplasmic reticulum stress, and apoptosis hypothalamic neurons obese mice. Swiss mice were distributed into three groups: Lean (Lean), sedentary animals fed a standard diet; (Obese), high‐fat diet (HFD); trained (T. Obese), with HFD concurrently subjected to an endurance protocol for 8 weeks. In protocol, ran on treadmill at 60% peak workload 1 hr, 5 days/week Twenty‐four hours after last...
Objective : To investigate the effects of different intensities acute exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle obese mice. Methods Swiss mice were randomly divided into four groups, fed either a standard diet (control group) or high fat (obese sedentary group 1 2) for 12 weeks. Two protocols used: swimming hour with without an overload 5% body weight. The tolerance test was performed to estimate whole-body sensitivity. Western blot technique used...
Montrezol, FT, Marinho, R, Mota, GdFAd, D'almeida, V, de Oliveira, EM, Gomes, RJ, and Medeiros, A. ACE gene plays a key role in reducing blood pressure the hyperintensive elderly after resistance training. J Strength Cond Res 33(4): 1119-1129, 2019-Hypertension is difficult disease to control exercise training hypertension control. Some individuals are not responsive training; so, we highlight polymorphism of I allele angiotensin-converting enzyme (ACE) as factor responsible for this lack...
To investigate the effects of a specific protocol undulatory physical resistance training on maximal strength gains in elderly type 2 diabetics.The study included 48 subjects, aged between 60 and 85 years, both genders. They were divided into two groups: Untrained Diabetic Elderly (n=19) with those who not subjected to Trained (n=29), training. The participants evaluated several types training's equipment before after protocol, by test one repetition. subjects trained three times per week...
PURPOSE: CLK2 protein (Cdc2-like kinase) after being phosphorylated by Akt, phosphorylates PGC-1a and consequently reduces the transcription of gluconeogenic genes. Obese insulin resistant (IR) animals showed lower levels in liver, which makes this an important therapeutic target control glucose homeostasis. On other hand, exercise is effective strategy to reduce IR hepatic production. So far, no study has been performed order assess role modulating obese animals. Therefore, aim was evaluate...
The SIRT1 deacetylase protein plays a crucial role in cellular metabolism. It is known that during aging decreases activity can contributes to development of metabolic disorders. PURPOSE: Determine if the reduction iNOS genetically (knockout) or by exercise related increased S-nitrosation and/or post-translational mechanisms responsible for this phenomenon. METHOD: “Young” (Y) (2 months), “sedentary-old” (O) (30 mo) “trained old” (TO) and “iNOS KO (iNOSKO) groups were submitted treadmill...
Investigate the effects of different protocols physical training (PT) on insulin sensibility (IS) and Akt phosphorylation (p-Akt) in skeletal muscle obese rats.Animals were distributed four groups according to diet training: Control: received standard chow (C); Sedentary obese: high fat (HFD) for 12 weeks (OS); Obese Trained 1: HFD PT without overload 6 (OT-1); 2: with 5% body weight (OT-2).Insulin tolerance test was used evaluate IS.Western blotting performed p-Akt total gastrocnemius...