A5081555110- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Respiratory viral infections research
- Hepatitis B Virus Studies
- Cancer Research and Treatments
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Immune responses and vaccinations
- interferon and immune responses
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Animal Virus Infections Studies
Inserm
2020-2024
Université d'Angers
2020-2024
Nantes Université
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2024
Extracellular vesicles (EVs) are mediators of intercellular communication in the tumor microenvironment. Tumor EVs commonly associated with metastasis, immunosuppression or drug resistance. Viral infections usually increase EV secretion, but little is known about effect oncolytic viruses (OVs) on EVs. Here, we investigated impact vesicular stomatitis virus (VSV) and vaccinia secreted by human melanoma thoracic cancer cells. We found that OV infection increases production These contain...
Attenuated measles virus (MV) exerts its oncolytic activity in malignant pleural mesothelioma (MPM) cells that lack type-I interferon (IFN-I) production or responsiveness. However, other the tumor microenvironment (TME), such as myeloid cells, possess functional antiviral pathways. In this study, we aimed to characterize interplay between MV and human MPM. We cocultured MPM cell lines with monocytes macrophages infected them MV. analyzed transcriptome of each type studied their secretion...