A5082313717- Ovarian function and disorders
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Diet, Metabolism, and Disease
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Reproductive Biology and Fertility
- Liver Disease Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Lipid metabolism and disorders
- Memory and Neural Mechanisms
University of Gothenburg
2017-2023
Heilongjiang University of Chinese Medicine
2019
The underlying mechanisms of polycystic ovarian syndrome (PCOS)-induced endometrial dysfunction are not fully understood, and although accumulating evidence shows that the use metformin has beneficial effects in PCOS patients, precise regulatory on function under conditions have only been partially explored.To address these clinical challenges, this study aimed to assess protein expression patterns glycolytic enzymes, estrogen receptor (ER), androgen (AR) along with differences...
Impaired progesterone (P4) signaling is linked to endometrial dysfunction and infertility in women with polycystic ovary syndrome (PCOS). Here, we report for the first time that elevated expression of receptor (PGR) isoforms A B parallels increased estrogen (ER) PCOS-like rat uteri. The aberrant PGR-targeted gene rats before after implantation overlaps dysregulated
Women with polycystic ovary syndrome (PCOS) are at high risk for nonalcoholic fatty liver disease (NAFLD). While insulin resistance is a common trait both PCOS and NAFLD, hyperandrogenism also considered to be key factor contributing PCOS, the molecular mechanisms behind interactions between in female remain largely unexplored. Using chronic treatment and/or human chorionic gonadotropin (hCG), we showed that all rats different treatments induced imbalance de novo lipogenesis mitochondrial...
Epidemiological studies and clinical observations suggest that nicotine, a major contributor of the global burden disease, acts in partially sex specific manner. Still, preclinical research has primarily been conducted males. More is thus required to define effects displayed by nicotine on female brain. To this end, rats received 15 injections either (0.36mg/kg) or saline, over 3-week period were then followed for up 3 months. Behavioral assessed using locomotor activity measurements...
Amphetamine addiction is associated with maladaptive actions that promotes continued use despite negative consequences, and a high risk of relapse even after protracted abstinence. Considering the role amygdala in regulating incentive motivation reward-based behavior, aim this study was to assess neuroadaptations subregions elicited by brief period discontinuous amphetamine exposure (2.0 mg/kg/day, 5 days) followed abstinence (2 weeks, 1 month, 3 months) male Wistar rats....
Abstract Impaired progesterone (P4) signaling is linked to endometrial dysfunction and infertility in women with polycystic ovary syndrome (PCOS). Here we report for the first time that elevated expression of receptor (PGR) isoforms A B parallels increased estrogen (ER) PCOS-like rat uteri. The aberrant PGR-targeted gene rats before after implantation overlaps dysregulated Fkbp52 Ncoa2 , two genes contribute development uterine P4 resistance. In vivo vitro studies effects metformin on...